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Thermogenetic Tools for Manipulating Neuronal Activity in Mammals

Thermogenetic Tools for Manipulating Neuronal Activity in Mammals
操纵哺乳动物神经元活动的热遗传学工具
批准号：
8461996
负责人：
Paul Garrity
金额：
$30.34万
依托单位：
BRANDEIS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-07-01 至 2015-04-30
来源：
https://reporter.nih.gov/project-details/8461996
关键词：
AdoptionAgonistAnimalsBehaviorBrainBrain regionCationsCharacteristicsChemicalsComplementDeep Brain StimulationDiseaseDrosophila genusEffectivenessEpilepsyExhibitsFocused Ultrasound TherapyGoalsHeatingHumanImplantInsectaInvestigationIon ChannelLightLinkMajor Depressive DisorderMammalsMapsMental DepressionMental disordersMusMutagenesisNeuronsObsessive-Compulsive DisorderParkinson DiseasePhysiologicalPhysiologyProceduresPropertyProteinsResearch PersonnelSliceSourceStimulusStructureSystemTRPA1 ChannelTechniquesTemperatureTestingTherapeuticToxic effectVariantWorkbasedesensitizationexcitatory neuronflyinhibitory neuronnervous system disorderoptogeneticspostsynapticreceptorresponsetool

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英文摘要
DESCRIPTION (provided by applicant): Manipulating the activity of identified neurons in brain circuits is essential for studying how they are organized and how they produce behavior. Manipulating circuit activity can also be used to treat neurological and psychiatric diseases including Parkinson's Disease, depression and epilepsy. Optogenetic tools have revolutionized our ability to manipulate neuronal activity. We propose to create a set of complementary thermogenetic tools. These have the potential to reliably provide stronger levels of activation and may be activated with less invasive stimulus delivery systems. At present, such tools are used exclusively in flies. We propose to modify these tools to optimize them for use in mammalian systems.
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国内基金
海外基金
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  • 资助金额：
    24.0万元
  • 批准年份：
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  • 负责人：
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  • 依托单位：
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