DENTAL DISEASES AND A GENE MAP OF HUMAN CHROMOSOME NO 4

两种遗传性牙病，牙本质发育不全(DGI)和 青少年牙周炎(JP)在五代人中是共分离的 马里兰州南部近亲繁殖的大型近亲。之前的研究记录了 DGI是作为常染色体显性遗传遗传的，而JP则表明 常染色体隐性遗传或X连锁显性遗传。 然而，出现的只有一种单一的重组遗传模式。 然而，只有一个重组个体出现在 这个家庭中的47个成员表明，在这个家族中观察到的太平绅士可能 也可能是常染色体显性基因所致。 决定gc表型的基因被分配到人类染色体上。 4号，与DGI基因座紧密连锁。 因此，通过推理，对数据段的初步分析 这个家族认为JP也在4号染色体上。 4号染色体的标记，即纤溶酶原基因和 着丝粒上的奎纳克林荧光多态，也会 在本研究中使用的。 这个家族中所有个体的这些标记的基因数据将是 分析以确定五个基因座之间的连锁关系。此外， 这样的信息还可以允许对线性序列进行更精确的排序 这些基因位于4号染色体着丝粒区域。

Two inherited dental conditions, dentinogenesis imperfecta (DGI) and juvenile periodontitis (JP) are co-segregating in five generations of a large inbred Southern Maryland kindred. Previous studies have documented that DGI is inherited as an autosomal dominant trait, while JP demonstrates either an autosomal recessive or X-linked dominant mode of inheritance. However, the appearance of only a single recombinant mode of inheritance. However, the appearance of only a single recombinant individual among the 47 members of this family suggests that the JP observed in this kindred may also be due to an autosomal dominant gene. The gene determining Gc phenotypes has been assigned to human chromosome No. 4 and has demonstrated close linkage with the locus for DGI. Therefore, by inference, the preliminary analysis of data from a segment this family suggest that JP is also on chromosome 4. Two additional markers for chromosome No. 4, i. e., the gene for plasminogen and the quinacrine fluorescent polymorphism at the centromere, will also be utilized in this study. Genotypic data for these markers on all individuals in this kindred will be analyzed to determine linkage relationships among the five loci. Moreover, such information may also permit more exact ordering of the linear sequence of these genes in the centromeric region of chromosome No. 4.