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EFFECT OF CIMETIDINE ON FOLACIN ABSORPTION

西米替丁对叶酸吸收的影响

基本信息

批准号：
3422326
负责人：
LYNN B BAILEY
金额：
$ 2.06万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-01-01 至 1986-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3422326
关键词：
acid base balance cimetidine folacin folate deficiency human old age (65+) human subject nutrition related tag radiotracer

项目摘要

This study is a pilot project by established researchers utilizing innovative techniques that can be used in further investigations of the effects of chronic drug use on nutritional status. The primary objective of this study is to determine if one drug, cimetidine, interferes with the absorption of either the mono- or polyglutamyl form of folacin. Folacin deficiency is a frequent occurrence in the elderly and is often associated with health-related consequences including megaloblastic anemia, malabsorption syndromes, and impaired immune and neurological functions. Cimetidine is the most frequently prescribed drug in the world and results in an elevation of jejunal pH which is hypothesized to interfere with the pH-sensitive folacin absorption mechanism. A triple-lumen jejunal perfusion technique utilizing H3-pteryolmonoglutamyl folacin (H3-PG-1) and C14-pteryolheptaglutamyl folacin (C14-PG-7) will be used to quantitate the effect of either a 0 or 300 mg dose of cimetidine on folacin absorption. Intraluminal pH changes in response to cimetidine or a placebo will be monitored in vivo throughout the perfusion by an electrode positioned in the jejunum. Ten healthy elderly (greater than 65 yrs) white male subjects will serve as their own controls. The relationship between cimetidine use and the development of folacin deficiency in the elderly will be characterized in this study. These data can be used to prevent the development of this debilitating deficiency in elderly cimetidine users.

这项研究是一个试点项目，由既定的研究人员利用可用于进一步调查的创新技术慢性药物使用对营养状况的影响。主要目的这项研究的目的是确定是否有一种药物，西咪替丁，叶酸的单谷氨酰或多谷氨酰形式的吸收。叶酸缺乏症在老年人中经常发生，并且通常与伴随着包括巨幼细胞性贫血在内的健康相关后果，吸收不良综合征以及免疫和神经功能受损。西咪替丁是世界上最常见的处方药，空肠pH值升高，这被假设为干扰 pH敏感的叶酸吸收机制。三腔空肠灌注技术的应用叶酸（H3-PG-1）和C14-蝶呤七谷氨酰叶酸（C14-PG-7）将被用于定量0或300 mg剂量西咪替丁对叶酸吸收对西咪替丁或甲氧苄啶的反应是管腔内pH的变化在整个灌注过程中，通过电极在体内监测安慰剂定位在空肠中。 10名健康老年人（大于65岁），白色男性受试者将作为他们自己的对照。西咪替丁的应用与叶酸的发展在老年人的缺乏将在这项研究的特点。这些数据可用于预防这种使人衰弱的缺乏症的发展，老年西咪替丁使用者。