EFFECT OF CIMETIDINE ON FOLACIN ABSORPTION

这项研究是一个试点项目，由知名研究人员利用 可用于进一步调查的创新技术 慢性药物使用对营养状况的影响。首要目标是 这项研究的目的是确定一种药物西咪替丁是否会干扰 叶酸的单谷氨酰基或多谷氨基形式的吸收。叶酸 缺乏症是老年人的常见病，常与 与健康相关的后果包括巨幼细胞性贫血， 吸收不良综合征，免疫和神经功能受损。 西咪替丁是世界上最常用的处方药和结果 在空肠pH值升高的情况下，这被认为会干扰 PH敏感的叶酸吸收机制。 H3-翼状旁腺素单谷氨酰胺三腔空肠灌注术 叶酸(H3-PG-1)和C14-翼基七氢叶酸(C14-PG-7) 用于量化0或300毫克剂量的西咪替丁对 叶酸吸收。西咪替丁或安慰剂对管腔内pH的影响 在整个灌流过程中，安慰剂将通过电极进行体内监测 放置在空肠内。10名健康的老年人(65岁以上) 男性受试者将作为他们自己的对照。 西咪替丁的使用与叶酸发育的关系 这项研究将以老年人的缺乏症为特征。这些数据 可以用来防止这种衰弱的虚弱的发展 西咪替丁的老年使用者。

This study is a pilot project by established researchers utilizing innovative techniques that can be used in further investigations of the effects of chronic drug use on nutritional status. The primary objective of this study is to determine if one drug, cimetidine, interferes with the absorption of either the mono- or polyglutamyl form of folacin. Folacin deficiency is a frequent occurrence in the elderly and is often associated with health-related consequences including megaloblastic anemia, malabsorption syndromes, and impaired immune and neurological functions. Cimetidine is the most frequently prescribed drug in the world and results in an elevation of jejunal pH which is hypothesized to interfere with the pH-sensitive folacin absorption mechanism. A triple-lumen jejunal perfusion technique utilizing H3-pteryolmonoglutamyl folacin (H3-PG-1) and C14-pteryolheptaglutamyl folacin (C14-PG-7) will be used to quantitate the effect of either a 0 or 300 mg dose of cimetidine on folacin absorption. Intraluminal pH changes in response to cimetidine or a placebo will be monitored in vivo throughout the perfusion by an electrode positioned in the jejunum. Ten healthy elderly (greater than 65 yrs) white male subjects will serve as their own controls. The relationship between cimetidine use and the development of folacin deficiency in the elderly will be characterized in this study. These data can be used to prevent the development of this debilitating deficiency in elderly cimetidine users.