Prophylactic effect of concomitant administration with verapamil and cimetidine on cisplatin-induced nephrotoxicity

维拉帕米和西咪替丁联合用药对顺铂引起的肾毒性的预防作用

• 批准号: 02670712
• 负责人: UEDA Toyofumi
• 金额: $ 1.34万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670712/
• 关键词: Cisplatin; Nephrotoxicity; Protection; Verapamil; Cimetidine; Methylpredonisolone; Antitumor effect; 培養腎尿〓〓細胞; ウリナスタシン; カルシウム拮抗剤

The protective effects of the concomitant use of verapamil and cimetidine on nephrotoxicity of cisplatin were not observed. Calcium blocker enhanced the renal accumulation of Pt and the nephrotoxicity of cisplatin. The prophylactic effect of methylpredonisolone against cisplatin nephrotoxicity was confirmed. The pretreatment with methylpredonisolone 4 hours prior to cisplatin injection plays an important role in protecting the kidney from cisplatin toxicity. Methylpredonisolone did not inhibit the antitumor effects of cisplatin.

维拉帕米和西咪替丁合用对顺铂肾毒性无保护作用。钙离子阻滞剂可增加铂在肾内的蓄积和顺铂的肾毒性。甲基强的松龙对顺铂肾毒性的预防作用得到证实。在顺铂注射前4小时给予甲基强的松龙预处理对保护肾脏免受顺铂毒性具有重要作用。甲基泼尼龙不抑制顺铂的抗肿瘤作用。

项目成果

Yasumasu T.: "Compartive study of cisplatin and carboplatin on pharmacokinetics,nephrotoxicity and effect on renal nuclear DNAsynthesis in rats" Pharmacology and Toxicology. 70. 143-147 (1992)

Yasumasu T.：“顺铂和卡铂对大鼠药代动力学、肾毒性和对肾核DNA合成影响的比较研究”药理学和毒理学。

Yasumasu T.: "Ultrastructural alteration and DNA synthesis of renal cell nuclei following cispltin or carbopltin injection in rats" Journal of Pharmacy and Pharmacology. 44. 885-887 (1992)

Yasumasu T.：“大鼠注射顺铂或卡铂后肾细胞核的超微结构改变和 DNA 合成”《药学和药理学杂志》。

Uozumi J.: "Calcium blockers enhance cisplatin-induced nephrotoxicity in rats" International Urology and Nephrology. 24. 549-553 (1992)

Uozumi J.：“钙阻滞剂增强顺铂诱导的大鼠肾毒性”国际泌尿学和肾病学。

Koikawa Y.: "Prophylactic effect of methylpredonisolone on cisplatin-induced nephrotoxicity in rats" Toxicology Letters (in press).

Koikawa Y.：“甲基泼尼松龙对顺铂诱导的大鼠肾毒性的预防作用”毒理学快报（正在出版）。

魚住二郎: "ラットにおけるCa拮抗剤のシスプラチン腎毒性に対する影響について" 西日本泌尿器科. 54. 1266-1269 (1992)

Jiro Uozumi：“Ca 拮抗剂对大鼠顺铂肾毒性的影响”West Japan Urology 54. 1266-1269 (1992)。