QUANTITATIVE SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY

定量单光子发射计算机断层扫描

• 批准号: 3405109
• 负责人: B LEONARD HOLMAN
• 金额: $ 23.11万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1985-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3405109
• 关键词: cerebral ischemia /hypoxia; clinical biomedical equipment; radionuclide emission tomography; radiotracer

The overall objective of this proposal is to develop a tomographic system which will allow accurate measurements of radiotracer biodistributions. We plan to concentrate on regional cerebral blood flow measurements using N-isopropyl I-123 p-iodoamphetamine and must, therefore, overcome the problems inherent in using I-123 labeled compounds. This will require alterations in our Harvard scanning multidetector emission computed tomography system, in our opinion the most promising instrument for single photon emission computer tomography. Three of these systems are currently in our laboratories. Our specific aims include improvement in the Harvard scanning multidetector tomographic brain system by increasing angular sampling, improving the collimators and improving attenuation correction; comparing the multidetector system with the rotating gamma camera through performance testing; determining the accuracy with which we can quantitatively measure activity distributions of I-123 in computer simulations of the regional variations in activity anticipated in the brain; comparing the accuracy of regional cerebral blood flow measurements using the percent injected dose of isopropyl I-123 iodoamphetamine with the modified Saperstein method introduced by Kuhl et al; determining the effect of agonists to the various brain receptors on the uptake of the radiotracer in the brain; and determining the extent of altered perfusion in patients with focal cerebral ischemia and with evolving and completed stroke. The later aspect of the study will be particularly important because it will determine the effectiveness of medical and surgical managements aimed at salvaging reversibly ischemic cerebral tissue. In addition, we will determine the prognostic importance of cerebral blood flow measurements early on in patients with acute cerebral ischemia and infarction.

本提案的总体目标是开发一种层析成像系统 这将允许放射性示踪剂生物分布的精确测量。 我们 计划集中于局部脑血流测量， N-异丙基I-123对碘苯丙胺，因此，必须克服 使用I-123标记化合物的固有问题。 这将需要 我们的哈佛扫描多探测器发射计算的变化 断层扫描系统，在我们看来，最有前途的仪器，为单一的 光子发射计算机断层扫描 其中三个系统目前 in our laboratories实验室. 我们的具体目标包括改善哈佛 通过增加角度的扫描多探测器断层摄影脑系统 采样、改进准直器和改进衰减校正; 将多探测器系统与旋转伽马照相机进行比较， 性能测试;确定我们可以 I-123活度分布的计算机定量测定 模拟2000 - 2001两年期预期活动的区域差异， 脑;比较局部脑血流测量的准确性 使用异丙基I-123碘苯丙胺的注射剂量百分比， Kuhl等人介绍的改良Saperstein法;确定影响 各种脑受体的激动剂对放射性示踪剂摄取的影响 在大脑中;并确定患者中改变灌注的程度 局灶性脑缺血以及进展性和完全性中风。 的 这项研究的后一方面将特别重要，因为它将 确定医疗和手术管理的有效性， 挽救可逆性缺血的脑组织 此外，我们会 确定脑血流测量的预后重要性 早期急性脑缺血和脑梗死患者。