PRODUCTION AND FATE OF HYDROXAMIC ACIDS IN HEPATOCYTES
PRODUCTION AND FATE OF HYDROXAMIC ACIDS IN HEPATOCYTES
批准号:
3420233
负责人:
MICHAEL D CORBETT
金额:
$6.24万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-08-01 至 1987-07-31
关键词:
DNA RNA chemical binding chemical reaction chemical structure chemical substitution chemical synthesis covalent bond cyclic amine high performance liquid chromatography hydroxamate liver cells macromolecule nitrosamines scintillation counter tissue /cell culture toxicant interaction toxin metabolism
中文摘要
这个程序的目的是阐明某些生化过程
英文摘要
The purpose of this program is to elucidate certain biochemical processes
that are involved in the toxicity of aromatic amines and nitroso aromatic
compounds. As a group the aromatic amines comprise some of mankind's most
important industrial chemicals. Their extensive use as pesticides in
modern agricultural practice continues to increase, yet a knowledge of
their biological fate and effects in living organisms is very incomplete.
Since many aromatic amines and related chemicals are known carcinogens, it
is necessary that a detailed knowledge of the metabolism of these chemicals
in higher animals be attained. This program will study the extent to which
model aromatic amines are metabolized to hydroxamic acids, since hydroxamic
acids are known to account for much of the toxicity of aromatic amines.
The program will examine the biochemical processes that convert nitroso
aromatic compounds to hydroxamic acids possessing unusual N-acyl groups.
The specific biochemical pathways responsible for such hydroxamic acids
arise from the interaction of a nitroso aromatic compound with a
thiamine-dependent enzyme. Another facile, but non-enzymatic reaction that
causes the production of the N-formyl type hydroxamic acids is the reaction
of a nitroso aromatic with glyoxylic acid. Primary hepatocyte cultures
prepared from rats will be the principal system in which these studies will
be conducted, although for comparative purposes primary hepatocyte cultures
for syrian hamsters will also be used. The results of this program will
provide valuable data to help design measures to minimize mankind's
exposure to or damage from potentially genotoxic chemicals.
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METABOLIC ACTIVATION OF ARYLAMINES IN LEUKOCYTES
-
批准号:3251131
-
项目类别:
-
资助金额:$9.87万
-
财政年份:1985
-
负责人:MICHAEL D CORBETT
-
依托单位:
METABOLIC ACTIVATION OF ARYLAMINES IN LEUKOCYTES
-
批准号:3251129
-
项目类别:
-
资助金额:$9.61万
-
财政年份:1985
-
负责人:MICHAEL D CORBETT
-
依托单位:
METABOLIC ACTIVATION OF ARYLAMINES IN LEUKOCYTES
-
批准号:3251127
-
项目类别:
-
资助金额:$6.04万
-
财政年份:1985
-
负责人:MICHAEL D CORBETT
-
依托单位:
METABOLIC ACTIVATION OF ARYLAMINES IN LEUKOCYTES
-
批准号:3251130
-
项目类别:
-
资助金额:$9.54万
-
财政年份:1985
-
负责人:MICHAEL D CORBETT
-
依托单位:
METABOLIC ACTIVATION OF ARYLAMINES IN LEUKOCYTES
-
批准号:3251124
-
项目类别:
-
资助金额:$7.94万
-
财政年份:1985
-
负责人:MICHAEL D CORBETT
-
依托单位:
METABOLIC ACTIVATION OF ARYLAMINES IN LEUKOCYTES
-
批准号:3251125
-
项目类别:
-
资助金额:$10.42万
-
财政年份:1985
-
负责人:MICHAEL D CORBETT
-
依托单位:
METABOLIC ACTIVATION OF ARYLAMINES IN LEUKOCYTES
-
批准号:3251128
-
项目类别:
-
资助金额:$6.75万
-
财政年份:1985
-
负责人:MICHAEL D CORBETT
-
依托单位:
PRODUCTION AND FATE OF HYDROXAMIC ACIDS IN HEPATOCYTES
-
批准号:3420234
-
项目类别:
-
资助金额:$7.37万
-
财政年份:1984
-
负责人:MICHAEL D CORBETT
-
依托单位:
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