CENTRAL MONOAMINES IN ACUTE-PHASE REACTION
CENTRAL MONOAMINES IN ACUTE-PHASE REACTION
批准号:
3405545
负责人:
CLARK M BLATTEIS
金额:
$14.1万
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-09-01 至 1993-08-31
中文摘要
最近,我们发现去甲肾上腺素(NE)引起的体温反应。
当它被微透析,而不是显微注射时,出人意料地不同
清醒豚鼠的视前区(PO),即去甲肾上腺素(NE)产生下坠
而不是核心温度(TCO)的上升。我们的研究表明,
微量注射去甲肾上腺素后TCO升高的主要原因是前列腺素E2
(PGE2)因显微注射造成组织损伤而释放
程序本身,不是由于药物,也就是说,它是人为的。
我们的微透析数据进一步表明存在一种功能性的
内源性去甲肾上腺素和前列腺素E_2的拮抗作用
PO中的浓度可能会相互影响TCO。的第一个目标
因此,这项拟议的研究旨在评估这一明显的功能NE-
PGE2拮抗作用。最近的各种其他研究表明,
体内和体外对去甲肾上腺素的不同反应
根据去甲肾上腺素的剂量而被激活,这些不同的影响
由不同的去甲肾上腺素受体亚型介导。亚型
人口和密度也被证明是不稳定的,受
在某些条件下会发生变化。由于不同的温度监管
据报道,集中管理的NE的效果也取决于
剂量和各种其他条件,这项拟议研究的第二个目的
是确定对NE的热响应方向是否为
肾上腺素能受体亚型依赖,并探讨其对
选定实验条件下的热响应。的第三个目标
本研究旨在探讨去甲肾上腺素(NE)在发热中的作用(S)。
以上假设的来龙去脉,自文献介绍以来的作用
中枢NE在发热反应中的作用,虽然广泛,但尚不确定,
可能是因为所有实验条件的变化性
这些研究。对其内在体温调节作用的评估
变送器将变得更容易,因为现在有了更具体的
受体激动剂和拮抗剂,并通过使用微透析,
最大限度地减少影响他人的创伤反应的混杂影响
三是药品管理模式。这项研究的结果应该有助于
解决早期发现之间的差异,并澄清NE的作用
对体温的中央控制。它们也可能与以下内容有关
其他与下丘脑去甲肾上腺素有关的功能,例如
神经内分泌和免疫系统之间的相互作用。
英文摘要
Recently, we found that the thermal response to norepinephrine (NE)
differed unexpectedly when it was microdialyzed, rather microinjected, into
the preoptic area (PO) of conscious guinea pigs; i.e., NE produced a fall
rather than a rise in core temperature (Tco). Our studies showed that the
Tco rise following microinjected NE was due largely to prostaglandin E2
(PGE2) released as a result of tissue injury caused by the microinjection
procedure itself, and was not due to the drug, i.e., it was artefactual.
Our microdialysis data further suggested that there exists a functional
antagonism between endogenous NE and PGE2; it appeared that their relative
concentrations in the PO might mutually influence Tco. The first aim of
this proposed study, therefore, is to evaluate this apparent functional NE-
PGE2 antagonism. Various other studies have lately indicated that
different responses to NE administration in vivo or application in vitro
are activated depending on the NE dose, and that these different effects
are mediated by different noradrenergic receptor subtypes. Subtype
populations and densities have also been shown to be inconstant, subject to
change under certain conditions. Since the different thermoreregulatory
effects of centrally administrated NE have also been reported to depend on
dosage and various other conditions, the second aim of this proposed study
is to determine whether the direction of thermal responses to NE is
adrenoceptor subtype-dependent, and to investigate the influence on the
thermal response of selected experimental conditions. The third aim of the
present study is to delineate the function(s) of NE during fever in the
context of the above hypotheses, since the literature on the role of
central NE in the febrile response, though extensive, is inconclusive,
probably because of the variability of experimental conditions used in all
the studies. Evaluation of the intrinsic thermoregulatory effects of this
transmitter will be made easier by the availability now of more specific
receptor agonists and antagonists and by the use of microdialysis, which
minimizes the confounding effects of traumatic reactions that affect other
modes of drug administration. The results of this study should help to
resolve the discrepancies among earlier findings and clarify the role of NE
in the central control of body temperature. They may also be pertinent to
other functions in which hypothalamic NE has been implicated, e.g., in the
interactions between the neuroendocrine and immune systems.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
PGE2 AND FEVER: INSIGHTS FROM TRANSGENIC MICE MODELS
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批准号:6609674
-
项目类别:
-
资助金额:$35.5万
-
财政年份:2000
-
负责人:CLARK M BLATTEIS
-
依托单位:
PGE2 AND FEVER: INSIGHTS FROM TRANSGENIC MICE MODELS
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批准号:6394115
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项目类别:
-
资助金额:$35.5万
-
财政年份:2000
-
负责人:CLARK M BLATTEIS
-
依托单位:
PGE2 AND FEVER: INSIGHTS FROM TRANSGENIC MICE MODELS
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批准号:6197592
-
项目类别:
-
资助金额:$31.36万
-
财政年份:2000
-
负责人:CLARK M BLATTEIS
-
依托单位:
PGE2 AND FEVER: INSIGHTS FROM TRANSGENIC MICE MODELS
-
批准号:6540083
-
项目类别:
-
资助金额:$35.5万
-
财政年份:2000
-
负责人:CLARK M BLATTEIS
-
依托单位:
PATHOPHYSIOLOGY OF ENDOTOXIN-MEDIATED FEVER
-
批准号:6539853
-
项目类别:
-
资助金额:$24.85万
-
财政年份:1996
-
负责人:CLARK M BLATTEIS
-
依托单位:
PATHOPHYSIOLOGY OF ENDOTOXIN-MEDIATED FEVER
-
批准号:6393767
-
项目类别:
-
资助金额:$24.85万
-
财政年份:1996
-
负责人:CLARK M BLATTEIS
-
依托单位:
PATHOPHYSIOLOGY OF ENDOTOXIN-MEDIATED FEVER
-
批准号:6131115
-
项目类别:
-
资助金额:$24.46万
-
财政年份:1996
-
负责人:CLARK M BLATTEIS
-
依托单位:
PATHOPHYSIOLOGY OF ENDOTOXIN-MEDIATED FEVER
-
批准号:2274167
-
项目类别:
-
资助金额:$20.8万
-
财政年份:1996
-
负责人:CLARK M BLATTEIS
-
依托单位:
PATHOPHYSIOLOGY OF ENDOTOXIN-MEDIATED FEVER
-
批准号:2750925
-
项目类别:
-
资助金额:$21.42万
-
财政年份:1996
-
负责人:CLARK M BLATTEIS
-
依托单位:
PATHOPHYSIOLOGY OF ENDOTOXIN-MEDIATED FEVER
-
批准号:6639489
-
项目类别:
-
资助金额:$24.85万
-
财政年份:1996
-
负责人:CLARK M BLATTEIS
-
依托单位:
PATHOPHYSIOLOGY OF ENDOTOXIN-MEDIATED FEVER
-
批准号:2460634
-
项目类别:
-
资助金额:$20.59万
-
财政年份:1996
-
负责人:CLARK M BLATTEIS
-
依托单位:
HEAT EXPOSURE, DEHYDRATION AND FEVER
-
批准号:3366885
-
项目类别:
-
资助金额:$17.9万
-
财政年份:1992
-
负责人:CLARK M BLATTEIS
-
依托单位:
HEAT EXPOSURE, DEHYDRATION AND FEVER
-
批准号:3366884
-
项目类别:
-
资助金额:$17.44万
-
财政年份:1992
-
负责人:CLARK M BLATTEIS
-
依托单位:
HEAT EXPOSURE, DEHYDRATION AND FEVER
-
批准号:2223831
-
项目类别:
-
资助金额:$19.89万
-
财政年份:1992
-
负责人:CLARK M BLATTEIS
-
依托单位:
CENTRAL MONOAMINES AND OPIOIDS IN ACUTE-PHASE REACTION
-
批准号:3405544
-
项目类别:
-
资助金额:$10.07万
-
财政年份:1986
-
负责人:CLARK M BLATTEIS
-
依托单位:
CENTRAL MONOAMINES IN ACUTE-PHASE REACTION
-
批准号:2264612
-
项目类别:
-
资助金额:$14.67万
-
财政年份:1986
-
负责人:CLARK M BLATTEIS
-
依托单位:
CENTRAL MONOAMINES AND OPIOIDS IN ACUTE-PHASE REACTION
-
批准号:3405536
-
项目类别:
-
资助金额:$9.12万
-
财政年份:1986
-
负责人:CLARK M BLATTEIS
-
依托单位:
CENTRAL MONOAMINES AND OPIOIDS IN ACUTE-PHASE REACTION
-
批准号:3405543
-
项目类别:
-
资助金额:$10.32万
-
财政年份:1986
-
负责人:CLARK M BLATTEIS
-
依托单位:
CENTRAL MONOAMINES IN ACUTE-PHASE REACTION
-
批准号:3405539
-
项目类别:
-
资助金额:$13.41万
-
财政年份:1986
-
负责人:CLARK M BLATTEIS
-
依托单位:
海外基金