BRAIN RECOVERY IN REVERSIBLE THROMBOTIC STROKE
可逆性血栓性中风的脑恢复
基本信息
- 批准号:3406512
- 负责人:
- 金额:$ 15.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1985
- 资助国家:美国
- 起止时间:1985-08-01 至 1992-03-31
- 项目状态:已结题
- 来源:
- 关键词:allopurinol anticoagulants antioxidants artificial intelligence brain edema calcium channel blockers cardiovascular pharmacology cerebral ischemia /hypoxia diene electron microscopy fibrinolytic agents histopathology laboratory rat lipid peroxides neutrophil perfusion photochemistry physiology plasminogen activator platelet aggregation platelet aggregation inhibitors prostacyclins singlet oxygen stroke superoxide dismutase thrombosis tissue /cell culture
项目摘要
We propose to administer reproducible thrombotic stroke to rats,
and to assess histopathologic, rheologic and physiological
indicators of tissue status during ischemia and following vascular
recanalization by the unique thrombolytic agent, hementin. Of
particular interest is to determine, following the ictus, the time
domain for which recanalization can be achieved without inducing
hemorrhage from ischemically compromised distal vascular segments.
Evidence of postischemic reperfusion injury will be sought in terms
of oxygen radical-stimulated tissue edema, neutrophil infiltration
and lipid peroxidation. The degree of inhibition of these
mediators of tissue destruction will be examined following
administration of specifically targeted quenching agents, such as
the stable prostacyclin analog iloprost, and the enzymatic
scavenger of superoxide radical, superoxide dismutase in both the
short-lived (in plasma) copper/zinc form and the unique long-lived
manganese form. Inasmuch as these studies encompass thrombotic
stroke in the induction phase and its therapy in the recovery
phase, as aided by mitigation of several deleterious aspects of
reperfusion in metabolically compromise brain tissue, clinically
relevant information may result.
Our models of thrombotic stroke are mediated by photoexcitation of
intravenously injected rose bengal dye, either by argon ion laser
irradiation of the middle cerebral artery, or by xenon arc lamp
irradiation of the exposed, translucent skull and the underlying
cortical microvasculature. Occlusion(s) appear in as white thrombi
containing agglutinated platelets in response to photochemically
damaged endothelium. Following hementin-induced recanalization at
clinically relevant times (less than 6 hours following the ictus),
edema will be assayed as brain water content, blood flow by the
14C-iodoantipyrine technique, metabolic status by oxygen tension,
potassium ion activity and hydrogen clearance, lipid peroxidation
by Schiff-base autofluorescence or conjugated dienes, and
neutrophil content by antimyeloperoxidase staining, and fluorescent
antibody or indium labeling. In terms of these indicators of
reperfusion injury, the ameliorating effect of the antioxidative
and antineutrophil agents will also be assessed. We will also
investigate optical means to improve the efficiency of
photochemically induced vascular occlusion; this development is
projected to benefit surgery of neovasculature in the brain and
eye.
我们建议给大鼠施用可重复性血栓性卒中,
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BRANT D WATSON其他文献
BRANT D WATSON的其他文献
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{{ truncateString('BRANT D WATSON', 18)}}的其他基金
Laser Catheter for Dethrombosis of Arterial Occlusion
激光导管用于动脉闭塞除血栓
- 批准号:
6848004 - 财政年份:2004
- 资助金额:
$ 15.62万 - 项目类别:
Laser Catheter for Dethrombosis of Arterial Occlusion
激光导管用于动脉闭塞除血栓
- 批准号:
6765177 - 财政年份:2004
- 资助金额:
$ 15.62万 - 项目类别:
PHOTOINDUCED THROMBOTIC STROKE--MECHANISMS AND THERAPY
光诱发血栓性中风——机制和治疗
- 批准号:
3406506 - 财政年份:1985
- 资助金额:
$ 15.62万 - 项目类别:
PEROXYLIPIDS/NITRIC OXIDE IN THROMBOTIC STROKE
血栓性中风中的过氧脂质/一氧化氮
- 批准号:
2264760 - 财政年份:1985
- 资助金额:
$ 15.62万 - 项目类别:
ACTIVE THROMBOSIS, THROMBOLYSIS, AND STROKE OUTCOME
活动性血栓形成、血栓溶解和中风结果
- 批准号:
6627651 - 财政年份:1985
- 资助金额:
$ 15.62万 - 项目类别:
PEROXYLIPIDS/NITRIC OXIDE IN THROMBOTIC STROKE
血栓性中风中的过氧脂质/一氧化氮
- 批准号:
2264761 - 财政年份:1985
- 资助金额:
$ 15.62万 - 项目类别:
PEROXYLIPIDS/NITRIC OXIDE IN THROMBOTIC STROKE
血栓性中风中的过氧脂质/一氧化氮
- 批准号:
2379621 - 财政年份:1985
- 资助金额:
$ 15.62万 - 项目类别:
ACTIVE THROMBOSIS, THROMBOLYSIS, AND STROKE OUTCOME
活动性血栓形成、血栓溶解和中风结果
- 批准号:
6045110 - 财政年份:1985
- 资助金额:
$ 15.62万 - 项目类别:
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