EVALUATION OF CALCIUM PHOSPHATE AS A ROOT CANAL FILLING

磷酸钙作为根管充填材料的评价

• 批准号: 3425027
• 负责人: AIDA A CHOHAYEB
• 金额: $ 2.45万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-01 至 1989-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3425027
• 关键词: biomaterial evaluation; calcium phosphate; dental adhesive /sealant; longitudinal animal study

The aim of this pilot study is to obtain preliminary in vivo data on the use of Calcium Phosphate Cement (CPC) as a root canal filling material. CPC has the potential of being an ideal root canal filler-sealer because it has many advantages including: high biocompatibility, good dimensional stability, good adaptation to the canal walls and good working time. A preliminary in vitro study showed that CPC is injectable into the root canal of an extracted tooth. The anterior, premolar and molar teeth of four cynomolgus monkeys will be utilized. The teeth in the left quadrants will be filled with CPC and the opposite control quadrants filled with gutta-percha using standard endodontic procedures. All teeth will be radiographed before treatment, immediately after filling and before sacrifice. Two animals will be sacrificed at the end of three months post-operatively and the remaining two monkeys sacrificed at the end of six months post-operatively. The harvested teeth embedded in the maxillae and mandibles will be fixed and processed for light and electron microscopic evaluation to determine the histocompatability of the CPC with the surrounding periapical tissues. The properties of CPC to be evaluated in this study will include: (1) sealing ability of the apical foramen and accessory canals, (2) dimensional stability in in vivo conditions, and (3) adaptability to the root canal surface, (4) periapical tissue reactions in case of under-or overfilling of the root canal. Quantitative data will be analyzed for significance using a two tailed "t" test. The data may permit evaluation of CPC as a more ideal root canal filling material. Data from this pilot study will be used to determine the feasibility of evaluating CPC as a root canal filling material in a larger number of monkeys over a longer experimental period. Eventually, it is intended, if data supports the effort, to initiate clinical trials of CPC.

这项初步研究的目的是获得初步的体内数据， 磷酸钙骨水泥（CPC）作为根管充填材料。 CPC具有成为理想根管充填材料的潜力， 具有生物相容性好，尺寸小， 稳定性、良好的渠壁适应性和良好的工作时间。 一 初步的体外研究表明，CPC可注射到牙根中 拔出的牙齿的管道。 将四只食蟹猴的前牙、前臼齿和臼齿 利用。 左侧象限的牙齿将填充CPC， 使用标准填充牙胶的相对对照象限 牙髓手术 所有牙齿在治疗前都要进行X光检查， 在填充后和牺牲前立即。 在术后3个月结束时处死两只动物 剩下的两只猴子在六个月后被处死 手术后。 采集到的牙齿嵌在上颌骨中， 将固定下颌骨并进行光镜和电镜处理 评价以确定CPC与 根尖周围组织 本研究将评估CPC的性能包括：（1） 根尖孔和副根管的封闭能力，（2）尺寸 在体内条件下的稳定性，以及（3）对根管的适应性 表面，（4）根尖周组织反应的情况下，不足或过度填充的 根管治疗 将使用双尾“t”分析定量数据的显著性 test. 这些数据可能允许评价CPC作为一个更理想的根管 填充材料 本试点研究的数据将用于确定 CPC作为根管充填材料的可行性 在较长的实验期内， 最终， 如果有数据支持，计划启动CPC的临床试验。