A PETROLEUM SOLVENT MORTALITY STUDY OF DRY CLEANERS

我们的目标是研究工人暴露于 商业干洗厂使用的主要溶剂和 接触者的死因和死亡率分布情况。 具体目标是： 1.对俄克拉荷马州的每一家商业干洗厂进行分类，在 1941-1984年，随时间推移按特定溶剂使用。 2.确定俄克拉荷马州干洗厂所有者/操作员的队列，并 具有已知Solent曝光量和曝光持续时间的操作员 1941-1984年。 3.确定所有死亡和死亡的标准化死亡率 1941-1984年间的选定死因包括癌症， 肾癌、肺癌和肝癌。 4.估计肾细胞癌患者的潜伏期。 5.确定高风险亚组，以便将来衡量实际接触情况 水平、对人类肾脏的非致命性急性和慢性影响以及影响 与接触石油或合成材料有关的生殖结局 俄克拉荷马州干洗店中的溶剂。 6.准备调查结果、分析和建议的最终报告 由这项研究得出的结论。 上述目标和具体目标将通过审查 1941年至1984年的年度许可证申请和其他可用资源 在俄克拉荷马州干洗委员会。预计会有一批 所有者/运营商总计5000人(80%-85%为白人男性) 将确定占总风险人群40%的风险。每个人 队列中的个人将按溶剂和持续时间进行分类 从受雇历史中暴露出来。未知植物的数量 溶剂型目前不到总数的百分之一。 在这些队列中，特定的SMR的年龄、时间、溶剂和暴露持续时间 对于选定的死因，将列出预计的潜伏期 和确定的高危亚组。 本研究设计将为以下研究提供数据 问题： 1.死因分布是否有差异？ 商业植物所有者/操作员或操作员死亡率 与全美发生的所有其他死亡事件相比，清洁工厂 白人男性，还是1941年至1984年间的俄克拉荷马州白人男性？ 2.已知的特定溶剂暴露有什么影响，如果有的话 暴露持续时间，以年为单位，关于年龄和时间的具体分布 这一人群的死亡原因和死亡率？

Our objective is to examine the association between workers' exposures to the primary solvents used in commercial dry cleaning plants and the distribution of causes of death and mortality rates among those exposed. The specific aims will be: 1. Categorize each commercial dry cleaning plant in Oklahoma, between 1941-1984, by specific solvent use over time. 2. Identify a cohort of Oklahoma dry cleaning plant owner/operators and operators with known solent exposures and durations of exposure between 1941-1984. 3. Determine the Standardized Mortality Ratio (SMR) for all deaths and selected causes of death occurring between 1941-1984 to include cancer, kidney, lung, and liver cancer. 4. Estimate latency in cases of renal cell carcinoma. 5. Identify high risk subgroups for future measurement of actual exposure levels, nonfatal acute and chronic effects on the human kidney, and effects on reproductive outcome related to exposure to petroleum or synthetic solvents among Oklahoma dry cleaners. 6. Prpare a final report of the findings, analyses, and recommendations resulting from this study. The above objective and specific aims will be achieved by review of the yearly license application from 1941 to 1984 and other resources available at the Oklahoma Dry Cleaning Board. It is anticipated that a cohort of owners/operators totaling 5,000 individuals, (80-85% white males) representing 40% of the total population of risk will be identified. Each individual in the cohort will be categorized by solvent and durations of exposure from employment history. The number of plants with unknown solvent type is currently less than one per cent of the total. Among this cohort, age-time-solvent and duration of exposure specific SMR's for selected causes of death will be tabulated, latency periods, estimated and high risk subgroups identified. This research design will provide data to address the following research questions: 1. Is there any difference in the distribution of causes of death or mortality rates among owner/operators or operators of commercial plants dry cleaning plants when compared to all other death occurring in all U.S. white males, or white male Oklahomans between 1941 and 1984? 2. What is the influence, if any, of known specific solvent exposures and durations of exposure, in years, on the age and time specific distribution of causes of death and mortality rates in this population?