A PETROLEUM SOLVENT MORTALITY STUDY OF DRY CLEANERS

干洗店石油溶剂死亡率研究

• 批准号: 3420306
• 负责人: NABIH R ASAL
• 金额: $ 12.35万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-01-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3420306
• 关键词: cancer risk; chlorohydrocarbon; disease /disorder proneness /risk; human mortality; hydrocarbons; occupational hazard; petroleum oil; solvents; toxicology

Our objective is to examine the association between workers' exposures to the primary solvents used in commercial dry cleaning plants and the distribution of causes of death and mortality rates among those exposed. The specific aims will be: 1. Categorize each commercial dry cleaning plant in Oklahoma, between 1941-1984, by specific solvent use over time. 2. Identify a cohort of Oklahoma dry cleaning plant owner/operators and operators with known solent exposures and durations of exposure between 1941-1984. 3. Determine the Standardized Mortality Ratio (SMR) for all deaths and selected causes of death occurring between 1941-1984 to include cancer, kidney, lung, and liver cancer. 4. Estimate latency in cases of renal cell carcinoma. 5. Identify high risk subgroups for future measurement of actual exposure levels, nonfatal acute and chronic effects on the human kidney, and effects on reproductive outcome related to exposure to petroleum or synthetic solvents among Oklahoma dry cleaners. 6. Prpare a final report of the findings, analyses, and recommendations resulting from this study. The above objective and specific aims will be achieved by review of the yearly license application from 1941 to 1984 and other resources available at the Oklahoma Dry Cleaning Board. It is anticipated that a cohort of owners/operators totaling 5,000 individuals, (80-85% white males) representing 40% of the total population of risk will be identified. Each individual in the cohort will be categorized by solvent and durations of exposure from employment history. The number of plants with unknown solvent type is currently less than one per cent of the total. Among this cohort, age-time-solvent and duration of exposure specific SMR's for selected causes of death will be tabulated, latency periods, estimated and high risk subgroups identified. This research design will provide data to address the following research questions: 1. Is there any difference in the distribution of causes of death or mortality rates among owner/operators or operators of commercial plants dry cleaning plants when compared to all other death occurring in all U.S. white males, or white male Oklahomans between 1941 and 1984? 2. What is the influence, if any, of known specific solvent exposures and durations of exposure, in years, on the age and time specific distribution of causes of death and mortality rates in this population?

我们的目标是研究工人接触 主要溶剂用于商业干洗厂和 受辐射者的死亡原因和死亡率分布。 具体目标是： 1.分类每个商业干洗厂在俄克拉荷马州，之间 1941-1984年，随着时间的推移使用特定溶剂。 2.确定一个队列的俄克拉荷马州干洗厂业主/经营者和 已知溶剂暴露和暴露持续时间的操作员 1941-1984. 3.确定所有死亡的标准化死亡率（SMR）， 1941-1984年期间发生的选定死亡原因包括癌症， 肾癌肺癌和肝癌 4.估计肾细胞癌病例的潜伏期。 5.确定高风险亚组，以便将来测量实际暴露 对人体肾脏的非致命性急性和慢性影响， 与接触石油或合成油有关的生殖结果 俄克拉荷马州干洗店的溶剂。 6.提交关于调查结果、分析和建议的最终报告 从这项研究中产生的。 上述目的和具体目标将通过审查 1941年至1984年的年度许可证申请和其他可用资源 在俄克拉荷马州干洗委员会工作 据估计， 业主/经营者共计5，000人（80-85%为白色男性） 占总风险人口的40%。 每个 队列中的个体将按溶剂和持续时间分类 从就业史来看。 未知的植物数量 溶剂型目前不到总数的百分之一。 在该队列中，年龄-时间-溶剂和暴露持续时间特异性SMR 对于选定的死亡原因，将制表，潜伏期，估计 和高风险亚组。 本研究设计将提供数据，以解决以下研究 问题： 1.在死亡原因的分布上是否有任何差异， 商业工厂所有者/经营者或经营者死亡率 清洁植物相比，所有其他死亡发生在所有美国。 是白色男性，还是1941年到1984年间的俄克拉荷马州白色男性？ 2.已知特定溶剂暴露的影响（如果有的话）是什么， 暴露持续时间（年），年龄和时间特异性分布 这一人群的死亡原因和死亡率