HYDROCARBON EXPOSURE & CHRONIC RENAL DISEASE

碳氢化合物暴露

• 批准号: 3420617
• 负责人: NABIH R ASAL
• 金额: $ 19.19万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-15 至 1992-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3420617
• 关键词: chronic disease /disorder; dialysis therapy; disease /disorder proneness /risk; epidemiology; glomerulonephritis; health surveys; hydrocarbons; kidney disorder diagnosis; kidney transplantation; low socioeconomic status; mathematical model; nephritis; occupational hazard; questionnaires; renal hypertension; renal toxin; social class

An on-going case-control study will be conducted investigate the role of chronic exposure to hydrocarbons in causing chronic renal failure. Because of an ever increasing number of end-stage renal disease patients (ESRD), those requiring dialysis or having had a renal transplant, they have become a major factor in Medicare expenditures. Elucidating the processes leading to ESRD and finding ways to control them are the most valid ways to reduce the personal, social and economic hardships produced by this condition. In the Oklahoma and Tulsa county areas of Oklahoma all adult patients with chronic renal failure (both those with ESRD and those not yet at that stage) having a confirmed diagnosis of chronic glomerulonephritis (CGN) will be identified and entered into the study as cases. All new cases over the next three years meeting these requirements will also be included. An age-sex matched control group will be selected from the general population using a random digit dialing technique. The target number of total cases and controls will be 500 of each. Each case and control will be administered a questionnaire which will elicit information on occupational hisotry, medical history and family medical history as well as pertinent demographic data. An exposure index to hydrocarbons will be calculated and used in an univariate and multivariate statistical analysis of risk factors for chronic renal failure. The univariate analysis will employ the Odds Ratio and the multivariate analysis will employ Cox's Linear Logistic Regression Model.

将进行一项正在进行的病例对照研究，以调查 长期接触碳氢化合物会导致慢性肾功能衰竭。 由于终末期肾病患者数量不断增加 (ESRD)，那些需要透析或进行过肾移植的人，他们 已成为医疗保险支出的主要因素。阐明 导致 ESRD 的过程并找到控制它们的方法是最重要的 减少个人、社会和经济困难的有效方法 通过这个条件。 在俄克拉荷马州和塔尔萨县地区，所有成年患者 患有慢性肾功能衰竭（患有终末期肾病（ESRD）和尚未达到终末期肾病（ESRD）的患者 该阶段）已确诊为慢性肾小球肾炎 （CGN）将被确定并作为案例进入研究。全新 未来三年符合这些要求的案件也将 包括。 将从一般人群中选择年龄性别匹配的对照组 使用随机数字拨号技术的人口。目标数量 病例总数和对照病例总数各为 500 例。每个病例和对照都将 进行问卷调查，以获取有关职业的信息 病史、病史和家族病史以及相关 人口统计数据。 将计算碳氢化合物暴露指数并将其用于 危险因素的单因素和多因素统计分析 慢性肾功能衰竭。单变量分析将采用优势比 多变量分析将采用 Cox 线性逻辑 回归模型。