NEURO-COGNITIVE EFFECTS OF EARLY UNILATERAL BRAIN DAMAGE

早期单侧脑损伤对神经认知的影响

• 批准号: 2266173
• 负责人: SUSAN C LEVINE
• 金额: $ 8.72万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2266173
• 关键词: attention; child psychology; chronic brain damage; cognition; cognition disorders; congenital neuromuscular disorder; electroencephalography; hemiplegia; human subject; intelligence; intelligence tests; longitudinal human study; magnetic resonance imaging; nervous system disorder diagnosis; neuropsychological tests; prognosis; psychological tests; reading

The proposed research investigates the effects of early unilateral brain lesions on subsequent neuro-cognitive development. Numerous studies have shown that age at the time of the brain damage has significant effects on the functional consequences of the damage. However, for the most part each study has investigated the effects of lesions on cognitive functioning at only a single point in time, providing only a "snapshot" of the consequences of the brain damage. This is particularly problematic when the brain damage is superimposed on a developed brain. The proposed research examines the effects of elapsed time since the brain damage on cognitive functioning in hemiplegic children with congenital lesions. Preliminary cross-sectional data suggest that elapsed time since lesion is an important factor in predicting the cognitive functioning of these children. In particularly, the overall IQ of these children appears to differ significantly from normals after, but not before age 7 - 8. Longitudinal information on the neuro-cognitive consequences of congenital unilateral lesions will be obtained by administering a broad range of cognitive and neurological tests to two groups of children we have already tested: 1) children with congenital unilateral brain lesions confirmed by CT-scans 2) children who do not have structural lesions, but who are matched to the brain damaged children for age, sex, race, socio-economic status and IQ at initial testing. Inclusion of such a control group will allow us to determine whether any changes in pattern or level of intellectual functioning over time are specific to early unilateral brain damage or rather, are IQ-level specific. In addition to cognitive and neurological tests, hemiplegic children will receive EEGs. This will allow us to relate EEG and/or seizure abnormalities to neuro-cognitive development. Finally, hemiplegic children will receive MRI studies in order to relate our understanding of the neuro- cognitive consequences of early brain lesions for the developing child should provide information about the time course of functional maturation of the nervous system as well as leading to better long-term planning of remediation programs for brain damaged children.

拟议的研究调查了早期单侧大脑的影响 损害随后的神经认知发展。 许多研究已经 表明脑损伤时的年龄对 损坏的功能后果。 然而，在大多数情况下，每个 研究调查了病变对认知功能的影响 仅提供单个时间点，仅提供该事件的“快照” 脑损伤的后果。 当 大脑损伤叠加在发达的大脑上。 拟议的研究检查了大脑自大脑形成以来经过的时间的影响 先天性偏瘫儿童认知功能受损 病变。 初步横截面数据表明，自 病变是预测认知功能的重要因素 这些孩子。 特别是，这些孩子的整体智商出现 在 7 - 8 岁之后（但在 7 - 8 岁之前）与正常人有显着差异。 先天性神经认知后果的纵向信息 单侧病变将通过施用广泛的 我们已经对两组儿童进行了认知和神经学测试 测试：1）经证实患有先天性单侧脑部病变的儿童 CT 扫描 2) 没有结构性病变但有结构性病变的儿童 与脑损伤儿童的年龄、性别、种族、社会经济状况相匹配 初始测试时的状态和智商。 纳入这样一个对照组将 让我们能够确定模式或水平是否有任何变化 随着时间的推移，智力功能是早期单侧大脑所特有的 或者更确切地说，伤害是智商级别特定的。 除了认知和神经系统测试外，偏瘫儿童还将 接收脑电图。 这将使我们能够将脑电图和/或癫痫发作联系起来 神经认知发育异常。 最后，偏瘫儿童 将接受 MRI 研究，以便将我们对神经的理解联系起来 早期脑损伤对发育中儿童的认知影响 应提供有关功能成熟时间过程的信息 神经系统以及导致更好的长期规划 脑损伤儿童的补救计划。