PAIN AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
PAIN AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
批准号:
3409652
负责人:
JOSE L OCHOA
金额:
$15.4万
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-04-01 至 1992-03-31
中文摘要
慢性神经病理性疼痛的异常神经机制
将在患者身上探索痛觉过敏,利用一系列新的
严格的神经生理学技术现在可用于人体研究和
在我们实验室使用中。建议的实验结果如下
期望提高诊断和管理的科学基础
这些患者中的许多人目前都经历了不良的临床
调查或者接受无效治疗的。
该实验计划将检验以下假设:
1.异常敏感(或感觉兴奋)的初级活动
伤害性感受器是自发疼痛和痛觉过敏的基础。
2.低阈值有髓机械感受器的活动异常兴奋
敏感的脊髓神经元可引起自发性疼痛和痛觉过敏。
3.低阈值兴奋的交感传出活动
初级机械感受器或敏化的伤害性感受器,触发异常
自发性疼痛和痛觉过敏的机制。
这些以科学为基础的假说现在可以直接在
患者,消除了从动物推断结果的必要性
研究。
同意的患者,亲自检查并通过我们的
神经感觉单位,将接受定量感觉测试和
对照实验引入前后的显微神经学检查
变量旨在:a)自然地或电地选择性地激活,
初级感觉单位的亚群;b)选择性地、机械地阻断
或药理上,初级传入纤维亚群;c)
选择性地兴奋或抑制交感神经亚群
传出神经元;d)药理上阻断全部或部分
感同身受的流出。
从我们的初步研究中得出的结果预示着巨大的收益
从基础科学和应用层面的这项研究。
英文摘要
Abnormal neuronal mechanisms underlying chronic neuropathic pain and
hyperalgesia will be explored in patients, making use of a novel array of
rigorous neurophysiological techniques now available for human studies and
in use in our laboratory. Results from the proposed experiments are
expected to improve the scientific foundation for diagnosis and management
of these patients, many of whom presently undergo ill conceived clinical
investigation or receive ineffectual treatment.
The experimental plan will test the following hypotheses:
1. Activity in abnormally sensitive (or ephaptically excited) primary
nociceptors underlies spontaneous pain and hyperalgesia.
2. Activity in low-threshold myelinated mechanoreceptors excites abnormally
sensitive spinal neurons to cause the spontaneous pain and hyperalgesia.
3. Sympathetic efferent activity, through excitation of low-threshold
primary mechanoreceptors or sensitized nociceptors, triggers the abnormal
mechanisms responsible for spontaneous pain and hyperalgesia.
These scientifically based hypotheses are now amenable to direct testing in
patients, eliminating the necessity of extrapolating results from animal
research.
Consenting patients, personally examined and preselected through our
Neurosensory Unit, will undergo quantitative sensory testing and
microneurography before and during introduction of controlled experimental
variables intended to: a) selectively activate, naturally or electrically,
subpopulations of primary sensory units; b) selectively block, mechanically
or pharmacologically, subpopulations of primary afferent fibers; c)
selectively excite or depress, reflexly, subpopulations of sympathetic
efferent neurons; d) block pharmacologically the whole or part of the
sympathetic outflow.
Results emerging from our preliminary studies promise significant yield
from this research at both basic scientific and applied levels.
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会议论文
PRIMARY C NOCICEPTORS AND C SYMPATHETICS IN CRPS
-
批准号:7245905
-
项目类别:
-
资助金额:$38.31万
-
财政年份:2006
-
负责人:JOSE L OCHOA
-
依托单位:
PRIMARY C NOCICEPTORS AND C SYMPATHETICS IN CRPS
-
批准号:7633139
-
项目类别:
-
资助金额:$39.5万
-
财政年份:2006
-
负责人:JOSE L OCHOA
-
依托单位:
PRIMARY C NOCICEPTORS AND C SYMPATHETICS IN CRPS
-
批准号:7033799
-
项目类别:
-
资助金额:$47.28万
-
财政年份:2006
-
负责人:JOSE L OCHOA
-
依托单位:
PRIMARY C NOCICEPTORS AND C SYMPATHETICS IN CRPS
-
批准号:7450871
-
项目类别:
-
资助金额:$38.34万
-
财政年份:2006
-
负责人:JOSE L OCHOA
-
依托单位:
NEW APPROACHES TO C NOCICEPTORS IN DIABETIC NEUROPATHY
-
批准号:6529411
-
项目类别:
-
资助金额:$36.52万
-
财政年份:1999
-
负责人:JOSE L OCHOA
-
依托单位:
NEW APPROACHES TO C NOCICEPTORS IN DIABETIC NEUROPATHY
-
批准号:6394323
-
项目类别:
-
资助金额:$35.85万
-
财政年份:1999
-
负责人:JOSE L OCHOA
-
依托单位:
NEW APPROACHES TO C NOCICEPTORS IN DIABETIC NEUROPATHY
-
批准号:6188421
-
项目类别:
-
资助金额:$35.19万
-
财政年份:1999
-
负责人:JOSE L OCHOA
-
依托单位:
NEW APPROACHES TO C NOCICEPTORS IN DIABETIC NEUROPATHY
-
批准号:6074976
-
项目类别:
-
资助金额:$36.55万
-
财政年份:1999
-
负责人:JOSE L OCHOA
-
依托单位:
PAIN AND PARESTHESIAS IN DIABETIC NEUROPATHY
-
批准号:2272620
-
项目类别:
-
资助金额:$21.65万
-
财政年份:1995
-
负责人:JOSE L OCHOA
-
依托单位:
PAIN AND PARESTHESIAS IN DIABETIC NEUROPATHY
-
批准号:2460596
-
项目类别:
-
资助金额:$22.52万
-
财政年份:1995
-
负责人:JOSE L OCHOA
-
依托单位:
PAIN AND PARESTHESIAS IN DIABETIC NEUROPATHY
-
批准号:2272619
-
项目类别:
-
资助金额:$21.29万
-
财政年份:1995
-
负责人:JOSE L OCHOA
-
依托单位:
PAINFUL SMALL CALIBER FIBER NEUROPATHY IN AGING HUMANS
-
批准号:3415370
-
项目类别:
-
资助金额:$16.6万
-
财政年份:1990
-
负责人:JOSE L OCHOA
-
依托单位:
PAINFUL SMALL CALIBER FIBER NEUROPATHY IN AGING HUMANS
-
批准号:3415368
-
项目类别:
-
资助金额:$12.05万
-
财政年份:1990
-
负责人:JOSE L OCHOA
-
依托单位:
PAINFUL SMALL CALIBER FIBER NEUROPATHY IN AGING HUMANS
-
批准号:3415369
-
项目类别:
-
资助金额:$14.85万
-
财政年份:1990
-
负责人:JOSE L OCHOA
-
依托单位:
PAINFUL SMALL CALIBER FIBER NEUROPATHY IN AGING
-
批准号:2267144
-
项目类别:
-
资助金额:$16.78万
-
财政年份:1990
-
负责人:JOSE L OCHOA
-
依托单位:
PAINFUL SMALL CALIBER FIBER NEUROPATHY IN AGING HUMANS
-
批准号:3415367
-
项目类别:
-
资助金额:$10.82万
-
财政年份:1990
-
负责人:JOSE L OCHOA
-
依托单位:
PAIN AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
-
批准号:3409653
-
项目类别:
-
资助金额:$16.8万
-
财政年份:1987
-
负责人:JOSE L OCHOA
-
依托单位:
PAIN AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
-
批准号:3409654
-
项目类别:
-
资助金额:$15.35万
-
财政年份:1987
-
负责人:JOSE L OCHOA
-
依托单位:
PAIN AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
-
批准号:3409655
-
项目类别:
-
资助金额:$16.14万
-
财政年份:1987
-
负责人:JOSE L OCHOA
-
依托单位:
PAIN AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
-
批准号:3409649
-
项目类别:
-
资助金额:$21.99万
-
财政年份:1987
-
负责人:JOSE L OCHOA
-
依托单位:
海外基金