NEUROLOGIC PARANEOPLASTIC SYNDROME

神经副肿瘤综合征

• 批准号: 3416550
• 负责人: HENRY M FURNEAUX
• 金额: $ 17.14万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3416550
• 关键词: SDS polyacrylamide gel electrophoresis; affinity chromatography; antitumor antibody; autoantigens; autoimmune disorder; breast neoplasms; gene expression; genetic promoter element; human tissue; immunocytochemistry; lung neoplasms; messenger RNA; molecular cloning; molecular oncology; molecular pathology; neoplasm /cancer immunology; nervous system disorder; neural degeneration; nucleic acid sequence; ovary neoplasms; protein purification; protein sequence; tissue /cell culture; transfection; tumor antigens; western blottings

The basis of this proposal is to investigate the molecular biology of antibody-associated paraneoplastic syndromes. Although rare, these neurological syndromes are of crucial importance since the patients harbor high-titer antibodies directed against human tumor antigens. Three antibody-associated paraneoplastic neurological syndromes which have been discovered and characterized in this laboratory will be further investigated at the molecular level. These syndromes include: the Yo syndrome associated with cerebellar dysfunction and antibodies directed against ovarian tumor antigens; the Hu syndrome associated with sensory neuronopathy and antibodies directed against small cell lung cancer antigens; the Ri syndrome associated with opsoclonus and antibodies directed against breast tumor antigens. The availability of these high-titer human antibodies provide a unique opportunity to: (a) Isolate human tumor antigens (b) Investigate tumor specific gene expression mechanisms. (c) Understand the molecular basis of the human anti-tumor immune response.

该提案的基础是研究 抗体相关的副肿瘤综合征 虽然罕见，但这些 神经系统综合征是至关重要的，因为患者 针对人肿瘤抗原的高滴度抗体。 三 抗体相关的副肿瘤性神经综合征， 在这个实验室里发现和表征的， 在分子水平上进行研究。 这些综合征包括： 与小脑功能障碍相关的综合征和针对 抗卵巢肿瘤抗原;与感觉器官相关的Hu综合征 神经元病和针对小细胞肺癌的抗体 与眼阵挛和抗体相关的Ri综合征 针对乳腺肿瘤抗原。 网站或资源的可用性 高滴度人抗体提供了独特的机会：（a）分离 人肿瘤抗原（B）研究肿瘤特异性基因表达 机制等(c)了解人类抗肿瘤的分子基础 免疫反应