NEUROLOGIC PARANEOPLASTIC SYNDROME

这一建议的基础是研究人的分子生物学。 抗体相关的副肿瘤综合征。虽然很少见，但这些 神经综合征是至关重要的，因为患者有 针对人类肿瘤抗原的高效价抗体。三 抗体相关的副肿瘤神经综合征 在这个实验室中发现和表征的将是进一步的 在分子水平上进行了研究。这些症状包括：Yo 与小脑功能障碍和抗体导向相关的综合征 抗卵巢肿瘤抗原；与感官相关的胡证 针对小细胞肺癌的神经病和抗体 抗原；与眼阵挛和抗体相关的Ri综合征 针对乳腺肿瘤抗原。这些产品的可用性 高滴度的人类抗体提供了一个独特的机会：(A)分离 人类肿瘤抗原(B)研究肿瘤特异性基因表达 机械装置。(C)了解人类抗肿瘤的分子基础 免疫反应。

The basis of this proposal is to investigate the molecular biology of antibody-associated paraneoplastic syndromes. Although rare, these neurological syndromes are of crucial importance since the patients harbor high-titer antibodies directed against human tumor antigens. Three antibody-associated paraneoplastic neurological syndromes which have been discovered and characterized in this laboratory will be further investigated at the molecular level. These syndromes include: the Yo syndrome associated with cerebellar dysfunction and antibodies directed against ovarian tumor antigens; the Hu syndrome associated with sensory neuronopathy and antibodies directed against small cell lung cancer antigens; the Ri syndrome associated with opsoclonus and antibodies directed against breast tumor antigens. The availability of these high-titer human antibodies provide a unique opportunity to: (a) Isolate human tumor antigens (b) Investigate tumor specific gene expression mechanisms. (c) Understand the molecular basis of the human anti-tumor immune response.