Optimisation of a novel hybrid vaccine for liver fluke disease in cattle

牛肝吸虫病新型混合疫苗的优化

• 批准号: LP160100442
• 负责人: Prof Terence Spithill
• 金额: $ 26.98万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-11-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160100442
• 关键词: Optimisation; novel; hybrid; vaccine; liver

Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. This project aims to optimise the formulation of novel fluke vaccine antigens by constructing combination hybrid recombinant antigens and using a protein adjuvant to improve immunogenicity, and test new antigens expressed in young flukes as vaccines and evaluate their ability to synergise with hybrid vaccines. Fasciola (fluke) infections cause serious economic losses to livestock production and fluke drug resistance threatens control, so new therapies such as a vaccine are needed. These vaccines should be evaluated in cattle trials. The major outcome plan is validation of hybrid antigens for commercial vaccine development for fluke control in cattle, leading to more sustainable beef and milk production in Australia.

牛肝吸虫病新型杂交疫苗的优化。本项目旨在通过构建组合杂交重组抗原，利用蛋白质佐剂提高免疫原性，优化新型吸虫疫苗抗原的配方，并测试在年轻吸虫中表达的新抗原作为疫苗，评估其与杂交疫苗的协同增效能力。片形吸虫（吸虫）感染给畜牧生产造成严重的经济损失，而且吸虫耐药性威胁到控制，因此需要新的治疗方法，如疫苗。这些疫苗应在牛试验中进行评估。主要成果计划是验证用于开发商业疫苗的混合抗原，以控制牛的吸虫，从而在澳大利亚实现更可持续的牛肉和牛奶生产。