Optimising Magnetic Susceptibility Mapping to Enhance MRI of Microbubbles

优化磁化率绘图以增强微泡的 MRI

• 批准号: EP/K027476/1
• 负责人: Karin Shmueli
• 金额: $ 12.83万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FK027476%2F1
• 关键词: Optimising; Magnetic; Susceptibility; Mapping; Enhance

Microbubbles (MBs) are an established ultrasound contrast agent but there has been significant recent interest in developing them as a contrast agent for Magnetic Resonance Imaging (MRI). MRI of MBs is useful because of its potential for combined applications in targeted imaging for monitoring and guidance of focused ultrasound therapies and drug and gene delivery. So far, MRI of synthesized MBs has been based on decreases in the MRI signal magnitude. Here, I propose to detect MBs using MRI magnetic susceptibility mapping which uses the phase of the complex MRI signal in gradient-echo MRI sequences. MBs have a different susceptibility than tissue; therefore the central idea here is that MBs present in an area of tissue will change its susceptibility so that it stands out as a bright or dark area in a MRI susceptibility map. I am one of the pioneers of susceptibility mapping: a new method which offers several advantages over conventional magnitude-based imaging. Susceptibility maps promise to enhance MRI of MBs because they are calculated from phase images which have higher contrast-to-noise ratios than standard magnitude images. The contrast in susceptibility maps directly represents the intrinsic magnetic susceptibility in an area and therefore has the potential to measure the MB concentration in that area. The susceptibility of MBs can be selected and tailored for different clinical applications so that MBs create bright (positive) contrast in susceptibility maps. All these advantages of MRI susceptibility mapping mean that it would improve the clinical applicability of MBs as a dual-modality contrast agent for MRI and ultrasound. Susceptibility mapping could also enhance MRI guidance and monitoring of MB-mediated drug and gene delivery and MB-enhanced focused-ultrasound surgery which is currently in use for treating uterine fibroids and is being developed to treat liver, bone, prostate and brain diseases. An EPSRC First Grant will be a springboard for a research programme which will ultimately lead to the development of a broad range of optimised MRI susceptibility-based techniques for diagnostic and therapeutic applications in preclinical models of disease and clinical imaging.

微泡（MB）是一种成熟的超声造影剂，但最近有显着的兴趣，在开发它们作为磁共振成像（MRI）的造影剂。MB的MRI是有用的，因为其在靶向成像中用于监测和引导聚焦超声治疗以及药物和基因递送的组合应用的潜力。到目前为止，合成MB的MRI一直基于MRI信号幅度的降低。在这里，我建议使用MRI磁化率映射，它使用梯度回波MRI序列中的复杂MRI信号的相位来检测MB。MB具有与组织不同的磁化率;因此这里的中心思想是，存在于组织区域中的MB将改变其磁化率，使得其在MRI磁化率图中突出为亮区或暗区。我是磁化率成像的先驱之一：一种新方法，它比传统的基于幅度的成像提供了几个优点。磁化率地图承诺，以提高磁共振成像的MB，因为它们是从相位图像，具有更高的对比度噪声比标准的幅度图像计算。磁化率图中的对比度直接表示区域中的固有磁化率，因此具有测量该区域中的MB浓度的潜力。可以针对不同的临床应用选择和定制MB的磁化率，使得MB在磁化率图中产生明亮（正）对比度。MRI磁敏感性标测的所有这些优点意味着它将提高MB作为MRI和超声双模态造影剂的临床适用性。敏感性映射还可以增强MRI引导和监测MB介导的药物和基因递送以及MB增强的聚焦超声手术，该手术目前用于治疗子宫肌瘤，并且正在开发用于治疗肝脏、骨骼、前列腺和脑部疾病。EPSRC的第一笔赠款将成为一项研究计划的跳板，该计划最终将导致开发广泛的优化MRI磁共振成像技术，用于临床前疾病模型和临床成像的诊断和治疗应用。

项目成果

The Effect of Large Slice Thickness and Spacing and Low Coverage on the Accuracy of Susceptibility Mapping

大切片厚度和间距以及低覆盖度对磁敏图绘制精度的影响

• 发表时间: 2016
• 作者: Karsa A

Evaluation of an Iterative Phase Replacement Method for Susceptibility Mapping in Regions with No MRI Signal

无 MRI 信号区域磁化率绘图的迭代相位替换方法的评估

• 发表时间: 2016
• 作者: Dixon E

Gadolinium-Enhanced Magnetic Susceptibility Contrast Is Reduced in the Corpus Callosum of a Mouse Model of Tauopathy

钆增强的 Tau 病小鼠模型胼胝体磁化率对比度降低

• 发表时间: 2015
• 作者: O'Callaghan J

Does Tau Pathology Play a Role in Abnormal Iron Deposition in Alzheimer's Disease? a Quantitative Susceptibility Mapping Study in the RTg4510 Mouse Model of Tauopathy

Tau 蛋白病理学在阿尔茨海默病铁沉积异常中发挥作用吗？

• 发表时间: 2016
• 作者: O'Callaghan J

The effect of low resolution and coverage on the accuracy of susceptibility mapping.

低分辨率和覆盖范围对敏感性映射准确性的影响。

• DOI: 10.1002/mrm.27542
• 发表时间: 2019-03
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Karsa A;Punwani S;Shmueli K
• 通讯作者: Shmueli K