GORDON RESEARCH CONFERENCE ON HORMONAL CARCINOGENESIS

这次会议的目的是为权威人士提供一个论坛， 积极参与各种学科的调查人员， 定义了激素致癌研究的前沿。是 重要的是，这些调查人员应继续定期举行会议， 目的是讨论各自领域的最新发展， 分析当前研究的意义，探讨新的策略， 未解决的问题，批判性地评估当前的理论，并发展 新的理论和方法。 1991年的会议将集中讨论管制 细胞的增殖、分化和转化。 参照 对于具有尿道相关肿瘤风险的特定组织， 会议将（1）讨论与以下方面有关的基本机制： 乳腺癌和前列腺癌;（2）严格评估细胞的作用 肿瘤的分化缺陷;（3）考虑关键的调节 激素调节生长的机制（积极和消极） 以及正常细胞的分化，并考虑这些细胞中的畸变 基本机制可能与肿瘤形成有因果关系;（4）检查 调节与类固醇生物合成，代谢， 共价中间体作为一种可能的致癌机制;（5） 确定雄激素、雌激素和孕激素在 在靶器官的发育和癌症的细胞生物学术语。主要 主题是：（1）通过生长因子和相互作用控制细胞生长 生长因子和激素之间的关系;（2）癌基因在 致癌作用;（3）生长控制过程中的基质-上皮相互作用 和致癌作用，以及（4）阴性和阳性生长对照， 例如，在一个实施例中，抑制因子、抗癌基因或肿瘤抑制因子。 本次会议是讨论荷尔蒙的主要持续会议 以全面、综合的方式研究致癌作用。

The aim of this conference is to provide a forum for authoritative investigators who are actively involved in the various disciplines which define the leading edges of research in hormonal carcinogenesis. It is important for such investigators to continue to meet regularly for the purpose of discussing the latest developments in their individual fields, to analyze the significance of current research, to discuss new tactics for unsolved problems, to critically evaluate current theories, and to develop new theories and approaches as needed. The 1991 conference will focus on the mechanisms which regulate the proliferation, differentiation and transformation of cells. With reference to the specific tissues at risk for hormonally associated neoplasms, the conference will (1) discuss the underlying mechanisms associated with breast and prostate cancer; (2) critically evaluate the role of cell differentiation defects in neoplasia; (3) consider key regulatory mechanisms (both positive and negative) by which hormones regulate growth and differentiation in normal cells, and consider how aberrations in these basic mechanisms might be causally related to neoplasia; (4) examine the regulation of genes involved with steroid biosynthesis, the metabolism of covalent intermediates as a possible mechanism of carcinogenesis; (5) define the neoplastic potential of androgens, estrogens and progestins in terms of the cell biology of development and cancer in target organs. Major themes are: (1) control of cell growth by growth factors and interactions between growth factors and hormones; (2) the role of oncogenes in carcinogenesis; (3) stromal-epithelial interactions during growth control and carcinogenesis, and (4) negative as well as positive growth controls, e.g., inhibitory factors, anti-oncogenes or tumor suppressors. This conference is the major ongoing meeting that discusses hormonal carcinogenesis in a comprehensive, integrated fashion.