PROGNOSIS AND VENTRICULAR CURVATURE IN TIMI TRIAL
TIMI试验中的预后和心室曲率
基本信息
- 批准号:3426781
- 负责人:
- 金额:$ 7.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1991
- 资助国家:美国
- 起止时间:1991-07-01 至 1993-06-30
- 项目状态:已结题
- 来源:
- 关键词:angiography artificial intelligence brain ventriculography computational neuroscience computer assisted diagnosis diagnosis design /evaluation fibrinolysis heart dimension /size heart function heart motion heart ventricle myocardial infarct sizing myocardial infarction noninvasive diagnosis prognosis
项目摘要
The principle objective of the proposed research is to determine whether
the diagnosis of regional dysfunction indicative of myocardial
infarction, and the assessment of prognosis can be more accurately
performed from analysis of regional left ventricular curvature than from
analysis of left ventricular wall motion. Data accumulated during the
NIH sponsored trial of Thrombolysis In Myocardial Infarction (TIMI) will
be analyzed. An advanced computational technique will be used to
correlate curvature measurements with diagnosis and with prognosis: the
artificial neural network, which applies the experience gained from
processing patient data to form associations between the input data
(ventricular curvature) and the desired output (infarct diagnosis,
prognosis). The accuracy with which the neural network assisted
evaluation of regional left ventricular curvature can distinguish infarct
(TIMI) patients from patients with normal coronary arteries will be
compared with the diagnostic accuracy of traditional wall motion analysis
and of neural network assisted analysis of wall motion. In addition, the
ability of the neural network to predict survival from analysis of
function will be compared with the accuracy of predicting survival using
Cox regression analysis. The results of the study will help to evaluate
patients with angina and nondiagnostic electrocardiograms, by improving
the accuracy with which regional dysfunction can be identified. The
results of the study may also help identify patients at high risk who may
benefit from more aggressive therapy. It is envisioned that artificial
neural network assisted analysis of regional ventricular curvature will
ultimately be applied to two-dimensional echocardiography, to which
curvature analysis is theoretically more suitable than wall motion, thus
enabling noninvasive diagnosis and prognostication.
拟议研究的主要目标是确定是否
指示心肌缺血的局部功能障碍的诊断
脑梗死,预后的评估可以更准确
从局部左心室曲率分析进行,而不是从
左室壁运动分析。 期间积累的数据
NIH赞助的心肌梗死溶栓试验(TIMI)将
被分析。 一种先进的计算技术将被用来
将曲率测量与诊断和预后相关联:
人工神经网络,它应用了从
处理患者数据以形成输入数据之间的关联
(心室曲率)和期望的输出(梗塞诊断,
预后)。 神经网络辅助的准确性
左室局部曲率的测定可区分梗死
(TIMI)患者的冠状动脉正常,
与传统室壁运动分析的诊断准确性相比
神经网络辅助分析室壁运动。 此外该
神经网络从分析中预测生存的能力
函数将与预测生存的准确性进行比较,
考克斯回归分析。 研究结果将有助于评估
心绞痛和非诊断性心电图患者,通过改善
区域性功能障碍的准确性。 的
这项研究的结果也可能有助于识别那些可能
从更积极的治疗中获益 据设想,人工
神经网络辅助分析局部心室曲率
最终应用于二维超声心动图,
曲率分析在理论上比室壁运动更适合,因此
从而能够进行非侵入性诊断和检查。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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FLORENCE SHEEHAN其他文献
FLORENCE SHEEHAN的其他文献
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{{ truncateString('FLORENCE SHEEHAN', 18)}}的其他基金
Simulation based Training in Acquiring Images of Diagnostic Quality at the Bedside to Improve Patient Safety
基于模拟的培训,在床边获取诊断质量图像以提高患者安全
- 批准号:
9132178 - 财政年份:2015
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Patient Self Monitoring to Transfer Physical Therapy Exercise from Clinic to Home
患者自我监控将物理治疗练习从诊所转移到家中
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8420163 - 财政年份:2012
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Expert Visual Guidance of Ultrasound for Telemedicine
远程医疗超声专家视觉引导
- 批准号:
6937826 - 财政年份:2004
- 资助金额:
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Expert Visual Guidance of Ultrasound for Telemedicine
远程医疗超声专家视觉引导
- 批准号:
7106451 - 财政年份:2004
- 资助金额:
$ 7.55万 - 项目类别:
Expert Visual Guidance of Ultrasound for Telemedicine
远程医疗超声专家视觉引导
- 批准号:
6807727 - 财政年份:2004
- 资助金额:
$ 7.55万 - 项目类别:
PROGNOSIS AND VENTRICULAR CURVATURE IN TIMI TRIAL
TIMI试验中的预后和心室曲率
- 批准号:
3426782 - 财政年份:1991
- 资助金额:
$ 7.55万 - 项目类别:
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