INTERNATIONAL SYMPOSIUM ON BIO-ORGANIC CHEMISTRY

已经决定举行为期三天的研讨会，重点讨论这三个问题 构成生物有机化学领域的主要特殊领域。 其中一堂课将讨论生物系统的模拟。这将是 包括酶模拟、膜模拟和生物运输模拟 系统。这项工作与理解自然生物学有关 流程，以及开发的对这些流程的成功模拟 有可能成为重要的药用化合物。第二节 研究具有生物重要性的天然产物的化学。 在这里，重点将是详细的化学研究，以了解 抗生素、卟啉和其他天然产物的生物合成 是重要的新陈代谢物质或有用的药用物质。这个 在这一领域寻求的理解具有相当大的健康相关性， 因为对新陈代谢的详细了解是许多 治疗方案；对涉及的生物合成途径的理解 生产具有药用活性的化合物也可能有助于 类似物和化学合成途径的设计。第三个领域 与生物大分子的化学有关，并将重点放在 关于蛋白质和核酸的有机化学工作。这个 这些物质的生物学重要性是非常明显的。越来越多的人， 生物有机化学家正致力于修饰蛋白质或 核酸化学和设计特定的试剂来执行 酶和其他重要蛋白质的选择性转化。一些人 非常成功的药物化学方法涉及到这样的工作，并且 这些关键生物分子上的化学反应也是极其复杂的 有助于研究生物功能。

It has been decided to hold a three-day symposium focused on the three principal special areas which comprise the field of bio-organic chemistry. One session will deal with the mimics of biological systems. This will include mimics of enzymes, of membranes, and of biological transport systems. Such work is relevant to understanding natural biological processes, and the successful mimics of these processes which are developed have the potential to be important medicinal compounds. The second section deals with the chemistry of natural products of biological importance. Here the focus will be detailed chemical studies to understand the biosynthesis of antibiotics, porphyrins, and other natural products which are either important metabolically or useful as medicinal substances. The understanding sought in this area is of considerable health relevance, since the detailed understanding of metabolism is a basis of many therapeutic schemes; an understanding of the biosynthetic pathways involved in the production of medicinally active compounds could also be helpful in the design of analogs and of chemical synthetic pathways. The third area has to do with the chemistry of biological macromolecules, and will focus on organic chemical work done on proteins and nucleic acids. The biological importance of these substances is very clear. Increasingly, bioorganic chemists are devoting their attention to modifying proteins or nucleic acids chemically and designing specific reagents to perform selective transformations of enzymes and other important proteins. Some very successful approaches to medicinal chemistry involve such work, and the chemical work on these key biological molecules is also extremely helpful in studies of biological function.