MODELING THE EFFECTS OF POROSITY IN COMPACT BONE TISSUE

模拟致密骨组织中孔隙率的影响

• 批准号: 3431907
• 负责人: HARRY A. HOGAN
• 金额: $ 4.88万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1994-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3431907
• 关键词: biomechanics; bone density; computer simulation; mechanical pressure; model design /development; normal ossification; physiologic bone resorption

The broad purpose of the proposed research is to further the understanding of the mechanical behavior of compact bone tissue at the micromechanics level. Micromechanics modeling techniques are used extensively and quite successfully in elucidating fundamental structure/property relationships and failure mechanisms for fiber reinforced composite materials. Their potential remains largely untapped, however, in studying bone and other biological materials. A micromechanics model consists of a small repeatable unit cell of the material that explicitly contains each discrete material constituent. This unit cell is intended to capture the essential microstructural features of the material in an average sense. The microstructure of Haversian compact bone tissue resembles that of a fiber reinforced composite, so this particular bone tissue type offers a natural starting point for applying composite material micromechanics methods. For Haversian bone, secondary osteons form the basic structural element and represent the fiber component. Micromechanics modeling will make possible characterization and prediction of the effects of histomorpho- metric parameters such as porosity, percent Haversian area, osteon type (collage fiber orientation), mineralization, and density on the macroscopic mechanical properties of bone tissue. Thus, knowing the effects of various pathological conditions on these parameters, the model will allow an assessment of the corresponding effects on mechanical behavior. The specific goals of the proposed research are to develop and test a micromechanics model of Haversian compact bone. Various methods for explicitly incorporating porosity into the model will be examined. The Collaborator on the project will provide detailed experimental results reporting elastic modulus measurements as a function of several histomorphometric parameters (including porosity). The model will be adapted, improved, and evaluated through direct comparison with this data. Most of the effort in this one-year project period will be needed for model development and assessment. Successful completion of the work will lay the foundation for follow-up studies involving further model development as well as extensive experimental testing for more definitive model verification. The current project is necessary to establish the feasibility of the method to warrant such longer-term study. The ultimate benefit of this line of research is a more complete and deterministic understanding of the basic science of bone mechanics. The emphasis in this initial effort is on porosity because of its critical role in the many major health problems arising from osteoporosis, whether through disuse, aging, or metabolic disorders.

拟议研究的广泛目的是进一步 对松质骨组织力学行为的认识 细观力学层面。采用细观力学建模技术 广泛而又相当成功地阐明了基本原理 纤维的结构/性能关系及失效机理 增强复合材料。他们的潜力在很大程度上仍然存在 然而，在研究骨骼和其他生物材料方面尚未开发。一个 细观力学模型由一个小的可重复的单胞组成。 明确包含每个离散材料成分的材料。 这个单胞的目的是捕捉基本的微结构 材料的平均意义上的特征。的微观结构。 哈弗斯致密骨组织类似于纤维增强的 复合体，所以这种特殊的骨组织类型提供了一个自然的开始 复合材料细观力学方法的应用要点。为 哈弗斯骨、次生骨形成基本结构元素， 表示光纤组件。细观力学建模将使 组织吗啡效应的可能表征和预测 度量参数，如孔隙率、哈弗斯面积百分比、骨质骨类型 (拼贴纤维取向)、矿化和密度 骨组织的宏观力学特性。因此，了解了 不同病理条件对这些参数的影响，模型 将允许评估对机械设备的相应影响 行为。拟议研究的具体目标是开发和 测试哈弗斯密质骨的细观力学模型。各种方法 为了将孔隙率明确地纳入模型中，将对其进行检查。 该项目的合作者将提供详细的实验 报告作为以下几个函数的弹性模量测量的结果 组织形态计量学参数(包括孔隙度)。模型将是 通过与此直接比较进行调整、改进和评估 数据。在这个为期一年的项目期内，将需要大部分工作 用于模型开发和评估。工程圆满完成 将为涉及进一步模型的后续研究奠定基础 开发以及广泛的实验测试，以获得更明确的 模型验证。当前项目是建立 这种方法的可行性保证了这种较长期的研究。这个 这条研究路线的最终好处是更完整和 对骨力学基础科学的确定性理解。这个 这一初始工作的重点是孔隙度，因为它的关键 在骨质疏松症引起的许多主要健康问题中所起的作用，无论是 通过停用、老化或代谢紊乱。