SENSORIMOTOR PLASTICITY--ROLE OF D1 AND D2 RECEPTORS

感觉运动可塑性——D1 和 D2 受体的作用

基本信息

  • 批准号:
    3430300
  • 负责人:
  • 金额:
    $ 6.71万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1992
  • 资助国家:
    美国
  • 起止时间:
    1992-09-30 至 1994-08-31
  • 项目状态:
    已结题

项目摘要

The aims of this proposal are to characterize the neuronal mechanisms underlying age-dependent plasticity of mesotelencephalic dopamine (DA) systems in rats. The literature suggests that the neural and behavioral effects of mesotelencephalic DA depletions are highly dependent upon the animal's age at the time of damage. Animals depleted during development are spared from the severe deficits in self-stimulation and sensorimotor function seen in comparably depleted adults. Moreover, the specific neural mechanisms underlying this sparing phenomenon differ as a function of age at the time of damage. These various forms of plasticity involve age-related changes in the functional interactions between D1 and D2 DA receptor subtypes. This proposal will allow our laboratory to establish two new techniques in order to further reveal the mechanisms underlying this age-dependent plasticity. First, we will employ IN VIVO MICRODIALYSIS IN FREELY MOVING ANIMALS in order to determine whether the age-related changes in the contributions of Dl and D2 receptors to behavior are paralleled by similar changes in the D1 and D2 mediation of DA, ACh, and GABA release within the basal ganglia. Such studies may reveal critical synapses associated with the sparing from deficits in sensorimotor and self-stimulation behavior. Second, we will utilize QUANTITATIVE DA RECEPTOR AUTORADIOGRAPHY to determine whether there are age-related changes in the density and/or distribution of D1 and D2 receptors that parallel the age-dependent effects of D1 and D2 receptors on behavior. Mesotelencephalic DA systems are involved in a wide range of behaviors, including; reward functions, self-stimulation, attention, and sensorimotor integration. Dysfunctions within these DA systems are associated with a variety of disorders relevant to mental health, including; drug abuse, learning deficits, affective disorders, Parkinson's disease, and schizophrenia. The results obtained from this proposal will provide insights into the neurochemical and neuroanatomical bases for plasticity in sensorimotor and self-stimulation behavior and how age constrains the extent of this plasticity.
这一建议的目的是表征神经元机制

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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JOHN P BRUNO其他文献

JOHN P BRUNO的其他文献

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{{ truncateString('JOHN P BRUNO', 18)}}的其他基金

Endogenous Kynurenic Acid Modulates Prefrontal ACh Levels and Cognitive Behavior
内源性犬尿酸调节前额叶乙酰胆碱水平和认知行为
  • 批准号:
    7994866
  • 财政年份:
    2009
  • 资助金额:
    $ 6.71万
  • 项目类别:
Endogenous Kynurenic Acid Modulates Prefrontal ACh Levels and Cognitive Behavior
内源性犬尿酸调节前额叶乙酰胆碱水平和认知行为
  • 批准号:
    7778026
  • 财政年份:
    2009
  • 资助金额:
    $ 6.71万
  • 项目类别:
Endogenous Kynurenic Acid Modulates Prefrontal ACh Levels and Cognitive Behavior
内源性犬尿酸调节前额叶乙酰胆碱水平和认知行为
  • 批准号:
    8196916
  • 财政年份:
    2009
  • 资助金额:
    $ 6.71万
  • 项目类别:
Endogenous Kynurenic Acid Modulates Prefrontal ACh Levels and Cognitive Behavior
内源性犬尿酸调节前额叶乙酰胆碱水平和认知行为
  • 批准号:
    8374421
  • 财政年份:
    2009
  • 资助金额:
    $ 6.71万
  • 项目类别:
High-speed detection of stimulant-induced cortical ACh release
高速检测兴奋剂诱导的皮质乙酰胆碱释放
  • 批准号:
    7280494
  • 财政年份:
    2006
  • 资助金额:
    $ 6.71万
  • 项目类别:
High-speed detection of stimulant-induced cortical ACh release
高速检测兴奋剂诱导的皮质乙酰胆碱释放
  • 批准号:
    7139406
  • 财政年份:
    2006
  • 资助金额:
    $ 6.71万
  • 项目类别:
High-speed detection of stimulant-induced cortical ACh release
高速检测兴奋剂诱导的皮质乙酰胆碱释放
  • 批准号:
    7418282
  • 财政年份:
    2006
  • 资助金额:
    $ 6.71万
  • 项目类别:
Annual Meeting of the International Behavioral Neuroscience Society
国际行为神经科学学会年会
  • 批准号:
    7590474
  • 财政年份:
    2002
  • 资助金额:
    $ 6.71万
  • 项目类别:
Annual Meeting of the International Behavioral Neuroscience Society
国际行为神经科学学会年会
  • 批准号:
    8195353
  • 财政年份:
    2002
  • 资助金额:
    $ 6.71万
  • 项目类别:
Annual Meeting of the International Behavioral Neuroscience Society
国际行为神经科学学会年会
  • 批准号:
    7408109
  • 财政年份:
    2002
  • 资助金额:
    $ 6.71万
  • 项目类别:

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研究乙酰胆碱如何通过衰老调节情景记忆
  • 批准号:
    542225-2019
  • 财政年份:
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衰老、乙酰胆碱和下丘脑
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  • 批准号:
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    $ 6.71万
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Aging, acetylcholine and the hypothalamus
衰老、乙酰胆碱和下丘脑
  • 批准号:
    7900012
  • 财政年份:
    2008
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    $ 6.71万
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Quantitative Analysis of Nicotinic Acetylcholine Receptors in Human Brain ; Effects of Aging and Smoking Cessation
人脑中烟碱乙酰胆碱受体的定量分析;
  • 批准号:
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  • 财政年份:
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AGING AND BRAIN ACETYLCHOLINE RELEASE
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