SENSORIMOTOR PLASTICITY--ROLE OF D1 AND D2 RECEPTORS
感觉运动可塑性——D1 和 D2 受体的作用
基本信息
- 批准号:3430300
- 负责人:
- 金额:$ 6.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-09-30 至 1994-08-31
- 项目状态:已结题
- 来源:
- 关键词:6 hydroxydopamine acetylcholine aging autoradiography corpus striatum developmental neurobiology dopamine dopamine receptor experimental brain lesion gamma aminobutyrate high performance liquid chromatography laboratory rat mature animal microdialysis neural plasticity neurochemistry neuropharmacology neuropsychology newborn animals nucleus accumbens receptor binding receptor expression receptor sensitivity self stimulation sensorimotor system
项目摘要
The aims of this proposal are to characterize the neuronal mechanisms
underlying age-dependent plasticity of mesotelencephalic dopamine (DA)
systems in rats. The literature suggests that the neural and behavioral
effects of mesotelencephalic DA depletions are highly dependent upon the
animal's age at the time of damage. Animals depleted during development
are spared from the severe deficits in self-stimulation and sensorimotor
function seen in comparably depleted adults. Moreover, the specific
neural mechanisms underlying this sparing phenomenon differ as a function
of age at the time of damage. These various forms of plasticity involve
age-related changes in the functional interactions between D1 and D2 DA
receptor subtypes.
This proposal will allow our laboratory to establish two new techniques
in order to further reveal the mechanisms underlying this age-dependent
plasticity. First, we will employ IN VIVO MICRODIALYSIS IN FREELY MOVING
ANIMALS in order to determine whether the age-related changes in the
contributions of Dl and D2 receptors to behavior are paralleled by
similar changes in the D1 and D2 mediation of DA, ACh, and GABA release
within the basal ganglia. Such studies may reveal critical synapses
associated with the sparing from deficits in sensorimotor and
self-stimulation behavior. Second, we will utilize QUANTITATIVE DA
RECEPTOR AUTORADIOGRAPHY to determine whether there are age-related
changes in the density and/or distribution of D1 and D2 receptors that
parallel the age-dependent effects of D1 and D2 receptors on behavior.
Mesotelencephalic DA systems are involved in a wide range of behaviors,
including; reward functions, self-stimulation, attention, and
sensorimotor integration. Dysfunctions within these DA systems are
associated with a variety of disorders relevant to mental health,
including; drug abuse, learning deficits, affective disorders,
Parkinson's disease, and schizophrenia. The results obtained from this
proposal will provide insights into the neurochemical and neuroanatomical
bases for plasticity in sensorimotor and self-stimulation behavior and
how age constrains the extent of this plasticity.
这一建议的目的是表征神经元机制
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOHN P BRUNO其他文献
JOHN P BRUNO的其他文献
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{{ truncateString('JOHN P BRUNO', 18)}}的其他基金
Endogenous Kynurenic Acid Modulates Prefrontal ACh Levels and Cognitive Behavior
内源性犬尿酸调节前额叶乙酰胆碱水平和认知行为
- 批准号:
7994866 - 财政年份:2009
- 资助金额:
$ 6.71万 - 项目类别:
Endogenous Kynurenic Acid Modulates Prefrontal ACh Levels and Cognitive Behavior
内源性犬尿酸调节前额叶乙酰胆碱水平和认知行为
- 批准号:
7778026 - 财政年份:2009
- 资助金额:
$ 6.71万 - 项目类别:
Endogenous Kynurenic Acid Modulates Prefrontal ACh Levels and Cognitive Behavior
内源性犬尿酸调节前额叶乙酰胆碱水平和认知行为
- 批准号:
8196916 - 财政年份:2009
- 资助金额:
$ 6.71万 - 项目类别:
Endogenous Kynurenic Acid Modulates Prefrontal ACh Levels and Cognitive Behavior
内源性犬尿酸调节前额叶乙酰胆碱水平和认知行为
- 批准号:
8374421 - 财政年份:2009
- 资助金额:
$ 6.71万 - 项目类别:
High-speed detection of stimulant-induced cortical ACh release
高速检测兴奋剂诱导的皮质乙酰胆碱释放
- 批准号:
7280494 - 财政年份:2006
- 资助金额:
$ 6.71万 - 项目类别:
High-speed detection of stimulant-induced cortical ACh release
高速检测兴奋剂诱导的皮质乙酰胆碱释放
- 批准号:
7139406 - 财政年份:2006
- 资助金额:
$ 6.71万 - 项目类别:
High-speed detection of stimulant-induced cortical ACh release
高速检测兴奋剂诱导的皮质乙酰胆碱释放
- 批准号:
7418282 - 财政年份:2006
- 资助金额:
$ 6.71万 - 项目类别:
Annual Meeting of the International Behavioral Neuroscience Society
国际行为神经科学学会年会
- 批准号:
7590474 - 财政年份:2002
- 资助金额:
$ 6.71万 - 项目类别:
Annual Meeting of the International Behavioral Neuroscience Society
国际行为神经科学学会年会
- 批准号:
8195353 - 财政年份:2002
- 资助金额:
$ 6.71万 - 项目类别:
Annual Meeting of the International Behavioral Neuroscience Society
国际行为神经科学学会年会
- 批准号:
7408109 - 财政年份:2002
- 资助金额:
$ 6.71万 - 项目类别:
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