STEREOELECTRONIC EFFECTCS AND SAR OF CALCIUM ANTAGONISTS

对两者进行合理设计、综合和研究的程序 晶体的构象和构型立体电子效应 二氢吡啶的构效关系(SAR) 提出了钙通道阻滞剂。构象 这个问题将用结晶学(固态)来研究。 和2D核磁共振(溶液中)。配置问题将是 通过不对称合成，利用手性乙烯基团 酰亚胺类化合物。

A program for the rational design, synthesis and study of both conformational and configurational stereoelectronic effects in the structure/activity relationship (SAR) of the dihydropyridine calcium channel blockers is proposed. The conformational question will be studied by crystallography (in the solid state) and 2D NMR (in solution). The configurational questions will be addressed by asymmetric synthesis, utilizing chiral vinylogous imidate equivalents.