STEREOELECTRONIC EFFECTCS AND SAR OF CALCIUM ANTAGONISTS

钙拮抗剂的立体电子效应和比吸收率

• 批准号: 3438756
• 负责人: Nicholas R. Natale
• 金额: $ 10.37万
• 依托单位: UNIVERSITY OF IDAHO
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3438756
• 关键词: calcium channel blockers; calcium transporting ATPase; chemical structure function; conformation; nuclear magnetic resonance spectroscopy

A program for the rational design, synthesis and study of both conformational and configurational stereoelectronic effects in the structure/activity relationship (SAR) of the dihydropyridine calcium channel blockers is proposed. The conformational question will be studied by crystallography (in the solid state) and 2D NMR (in solution). The configurational questions will be addressed by asymmetric synthesis, utilizing chiral vinylogous imidate equivalents.

一个程序的合理设计，综合和研究两者

项目成果

Theoretical calculations on calcium channel drugs: is electron transfer involved mechanistically?

钙通道药物的理论计算：电子传递是否涉及机械？

• DOI: 10.1016/0009-2797(90)90022-f
• 发表时间: 1990
• 期刊: Chemico-biological interactions
• 影响因子: 5.1
• 作者: Kovacic,P;Edwards,WD;Natale,NR;Sridhar,R;Kiser,PF
• 通讯作者: Kiser,PF

Tricarbonylchromium complexes of Hantzsch esters possess robust calcium antagonist activity.

Hantzsch 酯的三羰基铬络合物具有强大的钙拮抗活性。

• DOI: 10.1021/jm00084a023
• 发表时间: 1992
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: Hubler,TL;Meikrantz,SB;Bitterwolf,TE;Natale,NR;Triggle,DJ;Kwon,YW
• 通讯作者: Kwon,YW

4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter.

• DOI: 10.1016/j.bmc.2012.09.022
• 发表时间: 2012-11-15
• 期刊: BIOORGANIC & MEDICINAL CHEMISTRY
• 影响因子: 3.5
• 作者: Hulubei, Victoria;Meikrantz, Scott B.;Quincy, David A.;Houle, Tina;McKenna, John I.;Rogers, Mark E.;Steiger, Scott;Natale, N. R.
• 通讯作者: Natale, N. R.