FRAGILE X SYNDROME AND X-LINKED MENTAL RETARDATION

自第一次国际研讨会以来， 贝塞斯达脆性X综合征与X连锁精神发育迟滞 1983年，与此相关的信息稳步增长 精神错乱。出于这个原因，需要一个论坛来将 科学家与临床研究人员座谈交流 思想的结晶。拟于1989年举行的研讨会将集中讨论分子 和家庭研究，因为快速发展的技术已经 得到了新的信息。其他重要课题的进展， 值得注意的是X连锁精神发育迟滞的临床病因学 脆性X的表型和行为方面 综合征(FRA(X))、细胞遗传学、产前诊断、流行病学 和遗传学，以及连锁性，将被审查和假设和 对未来的研究问题进行了讨论。 该提案要求提供资金，以支付 前景看好的美国初级调查人员的陈述将 在竞争的基础上被选择。资金也被要求支付 杰出科学家的旅行，在全体会议上发表讲话 各届会议，以及研讨会的领导人，他们将 在他们之前或紧接着工作的重大费用 在研讨会之后。旅行奖将颁发给全体会议。 通常不会出席本次会议的会议演讲者，以及 对于被要求领导部门或在关键部门任职的人 委员会，但其机构或赠款不能提供 支持。 如果这项申请得到资助，它将做出重大贡献 为第四届脆弱X问题国际研讨会取得成功 综合征和X连锁精神发育迟滞。

Since the first meeting of the International Workshop on the Fragile X syndrome and X-linked Mental Retardation in Bethesda in 1983 there has been a steady growth of information related to these disorders. For this reason a forum is needed to bring together scientists and clinical investigators for discussion and exchange of ideas. The proposed workshop in 1989 will focus on molecular and family studies since the rapidly evolving technology has yielded new information. Advances on other important topics, notably the nosology of X-linked mental retardation, clinical aspects of the phenotypic and behavioral aspects of fragile X syndrome (fra(X)), cytogenetics, prenatal diagnosis, epidemiology and genetics, and linkage, will be reviewed and hypotheses and future research issues discussed. The proposal requests funds to pay the registration fees of promising junior American investigators whose presentations will be chosen on a competitive basis. Funds are also requested to pay for the travel of distinguished scientists to address plenary sessions, as well as the leaders of the workshop who will incur significant expenses for their work prior to or immediately following the workshop. The travel awards will be for plenary session speakers who normally would not attend this meeting, and for persons who have been asked to lead sections or serve on key committees, but whose institution or grants cannot provide full support. If this application is funded, it will make a major contribution to the success of the 4th International Workshop on the Fragile X syndrome and X-linked Mental Retardation.