FASEB SUMMER RSEARCH CONFERENCE--ROTEIN KINASES

本申请寻求FASE B夏季课程的部分资金 蛋白激酶研究会议将于7月19-24日举行， 1987年，科罗拉多州铜山。这是第二次 关于这一主题的会议。这次会议的目标是为 调查人员齐聚一堂，讨论现状和未来 各方面研究方向(生物化学、 免疫学、细胞生物学、分子生物学、遗传学、 药理学和病理生理学)。 蛋白激酶C最近被证明在 膜信号转导，从而最终影响 实际上，细胞功能的方方面面，比如分泌， 反作用、生长和分化。另一项重要的 最近的进展是酪氨酸蛋白激酶，它是 与生长因子受体和癌基因产物相关， 表明它参与了细胞生长，并可能 肿瘤发生学。此外，还取得了一些新的进展 在更经典的环核苷酸依赖和 钙调素/钙离子依赖的蛋白激酶，特别是在 底物专一性和调控的领域。从以下方面可以看出 随附的计划，这次会议是多学科的 自然，由许多领域的专家代表，如果不是全部的话 生物医学科学正在解决蛋白激酶问题，请访问 生物体、细胞、亚细胞和分子水平。这个 会议将成为一个有效的手段，促进我们的 对蛋白质磷酸化系统的了解如此基础 细胞功能和调节。

This application seeks partial funding for a FASEB Summer Research Conference on Protein Kinases to be held July 19-24, 1987 in Copper Mountain, Colorado. This is the second conference on the topic. The goal of this conference is to bring together investigators to discuss the current status and future directions of various aspects of research (biochemistry, immunology, cell biology, molecular biology, genetics, pharmacology and pathophysiology) on protein kinases. Protein kinase C has been shown recently to play a pivotal role in membrane signal transduction, thus ultimately influencing virtually every aspect of cell functions, such as secretion, counteraction, growth and differentiation. Another important recent advancement is on tyrosine protein kinase, which is associated with growth factor receptors and oncogene products, suggesting its involvements in cell growth and possibly tumorigenesis. In addition, some new advancements have been made in the more "classical" cyclic nucleotide-dependent and calmodulin/Ca2+-dependent protein kinases, particularly in the areas of substrate specificity and regulation. As can be seen from the attached program, the conference is multidisciplinary in nature, represented by experts in many, if not all, fields of biomedical sciences addressing the problems of protein kinases at the organismal, cellular, subcellular and molecular levels. The conference will serve as an effective means to foster our understanding on the protein phosphorylation system so basic to cellular function and regulation.