FASEB SUMMER RSEARCH CONFERENCE--ROTEIN KINASES

此申请寻求FASEB夏季的部分资金 蛋白激酶研究会议将于7月19日至24日举行， 1987年在科罗拉多的铜山。 这是第二 会议主题。 本次会议的目标是， 研究人员聚集在一起讨论现状和未来 研究的各个方面的方向（生物化学， 免疫学，细胞生物学，分子生物学，遗传学， 药理学和病理生理学）对蛋白激酶的作用。 蛋白激酶C最近已被证明在以下方面起关键作用： 膜信号转导，从而最终影响 几乎细胞功能的每个方面，如分泌， 反作用、生长和分化。 另一个重要 最近的进展是酪氨酸蛋白激酶， 与生长因子受体和致癌基因产物相关， 表明它参与了细胞生长， 肿瘤发生 此外，还取得了一些新的进展， 在更“经典”的环核苷酸依赖性和 钙调蛋白/Ca 2+依赖性蛋白激酶，特别是在 底物特异性和调节区域。 可以看出 附加程序，会议是多学科的， 自然，由许多领域的专家代表，如果不是所有领域， 解决蛋白激酶问题的生物医学科学. 有机体、细胞、亚细胞和分子水平。 的 会议将成为促进我们的 对蛋白质磷酸化系统的理解是如此的基础， 细胞功能和调节。

This application seeks partial funding for a FASEB Summer Research Conference on Protein Kinases to be held July 19-24, 1987 in Copper Mountain, Colorado. This is the second conference on the topic. The goal of this conference is to bring together investigators to discuss the current status and future directions of various aspects of research (biochemistry, immunology, cell biology, molecular biology, genetics, pharmacology and pathophysiology) on protein kinases. Protein kinase C has been shown recently to play a pivotal role in membrane signal transduction, thus ultimately influencing virtually every aspect of cell functions, such as secretion, counteraction, growth and differentiation. Another important recent advancement is on tyrosine protein kinase, which is associated with growth factor receptors and oncogene products, suggesting its involvements in cell growth and possibly tumorigenesis. In addition, some new advancements have been made in the more "classical" cyclic nucleotide-dependent and calmodulin/Ca2+-dependent protein kinases, particularly in the areas of substrate specificity and regulation. As can be seen from the attached program, the conference is multidisciplinary in nature, represented by experts in many, if not all, fields of biomedical sciences addressing the problems of protein kinases at the organismal, cellular, subcellular and molecular levels. The conference will serve as an effective means to foster our understanding on the protein phosphorylation system so basic to cellular function and regulation.