GORDON RESEARCH CONFERENCE--MOTILE & CONTRACTILE SYSTEM

戈登研究会议--MOTILE

• 批准号: 3435612
• 负责人: David John Hartshorne
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435612
• 关键词: cell motility; cytoskeleton; meeting /conference /symposium; muscle contraction; muscle proteins

This will be the first Gordon Research Confernce on MOTILE AND CONTRACTILE SYSTEMS. The work to be presented will start with the very recent discoveries on the role of ATP hydrolysis in actin polymerization and the regulation of actin polymerization by actin-binding proteins such as profilin and gelsolin. Mechanisms of regulation of myosin filament formation and actomyosin ATPase activity will be discussed with emphasis on the role of heavy chain phosphorylation (discovered in amoeba but now known to occur in mammalian non-muscle and cardiac muscle cells) and the role of the Ca/calmodulin-binding protein caldesmon. For the first time, sequence data (at the DNA level) are available for non-muscle myosin heavy chains and these data will be discussed in comparison to the sequences of muscle myosin heavy chains. Recent information on the localization of the sites on actin and myosin that are involved in their interaction will be presented as will interesting new data on the ATP-binding site of muscle and non-muscle myosins. The organization of the cytoskeleton of non-muscle cells will be discussed including its dynamic regulation during platelet activation and the effects of actin mutants on cytoskeletal organization and function of yeast and dictyostelium. Genes encoding contractile proteins are often members of multigene families coding for multiple protein isoforms that are expressed in a tissue-specific and developmental-stage specific manner. Recent studies focus on the differntial regulation of expression of individual genes within a multigene family and the coordinate expression of cytoskeleton protein genes between different multigene families. Motile systems involving microtubules will be discussed: both the microtubule-dynein system and the very exciting, newly discovered microtubule-kinesin system that seems to be involved in axonal transport. The final session will cover the role of second messengers (cyclic nucleotides, inositol triphosphate and diacylglycerol) in cell motillity, cell shape changes and muscle contraction. The Conference will include approximately 25 formal presentations by invited speakers with major emphasis on discussion by invited and uninvited participants. The latter, especially, will be encouraged to present posters of their work and one session will be devoted to discussion of the posters. This will be the first meeting of scientists involved in so many different yet closely related aspects of the motile and contractile systems.

这将是第一次戈登研究会议上的汽车和可伸缩性 系统. 要介绍的工作将从最近的 发现ATP水解在肌动蛋白聚合中的作用， 通过肌动蛋白结合蛋白调节肌动蛋白聚合， profilin和gelsolin。 肌球蛋白丝的调控机制 形成和肌动球蛋白ATP酶活性将重点讨论 重链磷酸化的作用（在变形虫中发现， 发生在哺乳动物的非肌肉和心肌细胞）和作用， 钙/钙调蛋白结合蛋白caldesmon。 第一次，序列 非肌肉肌球蛋白重链的数据（在DNA水平）可用 这些数据将与肌肉序列进行比较 肌球蛋白重链。 网站本地化的最新信息 肌动蛋白和肌球蛋白的作用， 提出了将有趣的新数据的ATP结合位点的肌肉 和非肌肉肌球蛋白。 非肌肉细胞骨架的组织 包括血小板聚集过程中的动态调节 肌动蛋白突变体对细胞骨架结构的影响 以及酵母菌和网囊藻的功能。 编码收缩性 蛋白质通常是多基因家族的成员，其编码多种 蛋白质同种型，其在组织特异性和 发展阶段的具体方式。 最近的研究集中在 多基因内单个基因表达的差异调节 家族和细胞骨架蛋白基因的协调表达 不同的多基因家族 涉及微管的能动系统将 微管动力蛋白系统和非常令人兴奋的， 新发现的微管驱动蛋白系统似乎参与了 轴突运输 最后一次会议将讨论第二次会议的作用， 信使（环核苷酸、三磷酸肌醇和甘油二酯） 细胞运动、细胞形状改变和肌肉收缩。 的 会议将包括约25个正式演讲，邀请 发言者主要强调应邀和未应邀的讨论 参与者 特别是后者，将被鼓励提出 他们的工作海报和一个会议将专门讨论 海报. 这将是第一次科学家们参加如此多的会议， 运动和收缩系统的不同但密切相关的方面。