WORKSHOP ON PORPHYRIN PHOTOTHERAPY

这项提案是请求美国国立卫生研究院支持一个关于使用 用于肿瘤定位和光敏的卟啉。 在过去的几年里，已经发现了卟啉产品hpd。 能够集中在肿瘤部位的。肿瘤性病变可以是 通过产生的荧光进行识别，并选择性地通过 在红光照射下，卟啉催化的能量转移。 定期会议对于工人之间的信息交流很有用 在现场，并提供临床前和临床的最新情况 对开始研究的个人有益的结果 光敏现象。 过去在美国举行的三次这样的会议是在1981年9月举行的(与 1983年4月和1984年7月(在国家卫生研究院的支持下)。这些 都是成功的会议，为目标提供了一种有用的形式 勾勒出上面的轮廓。所有这些都导致出版了包含以下内容的书籍 与会者的贡献；这些构成了参考的基础 这一领域的材料。在米兰也有一些外国会议。 (1983)和撒丁岛(1985)。 在下一次这样的会议上，建议临床和医疗工作者 邀请临床前研究小组和卟啉方面的专家 化学和脂蛋白生物学。后一个主题源于一些 最近的信息表明，卟啉-脂蛋白相互作用 为肿瘤定位现象的研究提供依据。低密度脂蛋白的数量 不同组织中的受体与卟啉蓄积有关。 这种持续的信息交流对于取得进展至关重要 在这一新的抗肿瘤模式中保持不变。

This proposal is a request for NIH support for a Workshop on use of porphyrins for tumor localization and photosensitization. During the past several years, the porphyrin product HPD has been found capable of concentrating in tumor loci. Neoplastic lesions can be identified by the resulting fluorescence, and selectively destroyed, via porphyrin-catalyzed energy transfer, upon irradiation with red light. Periodic conferences are useful for exchange of information among workers in the field, and for providing updates of pre-clinical and clinical results for the benefit of individuals who are beginning research on photosensitization phenomena. The past three such conferences in the US were held in September 1981 (with NIH support), in April 1983 and in July 1984 (with NIH support). These were all successful meetings, providing a useful format for the goals outlind above. All resulted in publication of books containing contributions from the participants; these form the basis for the reference material in this field. There have also been foreign conferences in Milan (1983) and in Sardinia (1985). During the next such meeting, it is proposed that workers from clinical and preclinical research groups be invited, along with experts in porphyrin chemistry and lipoprotein biology. The latter topic derives from some recent information which suggests that porphyrin-lipoprotein interactions provide the basis for the tumor-localization phenomena. Numbers of LDL receptors in different tissues are correlated with porphyrin accumulation. This continued exchange of information is essential in order that progress in this new anti-tumor modality be maintained.