SYMPOSIUM ON PHOTODYNAMIC THERAPY

该提案请求美国国立卫生研究院支持在温哥华举行的研讨会 1990年6月20日。主题将是光敏剂的使用 肿瘤根除。这次会议将与1990年的会议同时举行。 美国光生物学学会将提供空间和 协助安排。配套资金将由QLT提供，a 总部位于温哥华的组织从事与肿瘤相关的研究 光敏化。 给药后，卟啉产物HDP定位于肿瘤部位。 活着。肿瘤损伤可以通过产生的荧光来识别， 并且可以通过卟啉催化的光氧化选择性地被破坏， 在红光照射下。最近，其他染料也出现了 为此目的而开发的。这些显示了关于以下方面的改进的性能 作用光谱和定位以及毒性试验正在进行中。 定期会议对于工人之间的信息交流很有用 在现场，并提供临床前和临床的最新情况 对开始研究的个人有益的结果 光敏现象。 在1990年的会议上，有人提议新老工人混合在一起 受邀讨论光动力学的临床前方面 心理治疗。QLT研讨会定于1989年6月会议后12个月举行 在波士顿。研讨会的形式将包括一场关于 Dan DoIron所著的光传输系统，以及由 汤姆·多尔蒂或查克·戈默。其他会谈将被安排，以便 提供充足的讨论时间。将对所有讨论进行录音 可供参与者和其他人使用。

This proposal requests NIH support for a Symposium to be held in Vancouver 20 June 1990. The topic will be the use of photosensitizing agents for tumor eradication. This will be held in conjunction with the 1990 meeting of the American Society for Photobiology which will provide space and assist with arrangements. Matching funds will be provided by QLT, a Vancouver-based organization engaged in research relating to tumor photosensitization. After administration, the porphyrin product HDP localizes at tumor loci in vivo. Neoplastic lesions can be identified by the resulting fluorescence, and can be selectively destroyed, via porphyrin-catalyzed photo-oxidation, upon irradiation with red light. More recently, other dyes have been developed for this purpose. These show improved properties with regard to action spectrum and localization, and toxicity trials are underway. Periodic conferences are useful for exchange of information among workers in the field, and for providing updates of pre-clinical and clinical results for the benefit of individuals who are beginning research on photosensitization phenomena. During the 1990 meeting, it is proposed that a mix of new and old workers in the field be invited to discuss pre-clinical aspects of photodynamic therapy. QLT Workshop is scheduled 12 months after the June 1989 meeting in Boston. The format of the Symposium will include a 'school' lecture on Light Delivery Systems by Dan Doiron, and a 'general-interest' lecture by Tom Dougherty or Chuck Gomer. The other talks will be scheduled so as to provide ample discussion time. Recordings of all discussion will be made available for participants and others.