GORDON RESEARCH CONFERENCE ON KALLIKREINS AND KININS

激肽释放酶和激肽戈登研究会议

• 批准号: 3435588
• 负责人: HARRY S MARGOLIUS
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-02-01 至 1987-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435588
• 关键词: enzyme substrate; kallikreins; travel

Kallikreins and kininogenases (kinin-generating enzymes) are serine proteases with limited and specific proteolytic capability. The existence of a large kallikrein gene family (announced at the last Gordon Conference); the diversity of localization sites including: plasma, sperm, peripheral exocrine glands and their secretions, renal and intestinal epithelial cells, various brain nucleii, pituitary and pineal, red blood cell membrane and other formed elements of blood, the vascular wall, as well as closely related enzymes in invertebrates and bacteria; the possibility that the "kallikrein-kinin" system is but a paradigm for many other kallikrein-regulated, substrate-product systems because tissue kallikreins can attack several newly identified substrates, (e.g., atrial natriuretic factor precursors, apolipoprotein B100); are all reasons for a markedly heightened interest since the 1983 Gordon Conference. It is now being suggested that the tissue kallikrein gene family may be responsible for the synthesis of several closely-related kallikreins with diverse, but bond-specific proteolytic activities which regulate the elaboration of many peptide hormones. This exciting idea is being tempered by the realization that there is, as yet, no proof that tissue kallikreins act upon any endogenous substrates, other than kininogens. Data are being gathered in many laboratories which addresses this issue, most important to the full description of the functional responsibilities of the kallikreins and of the kinins. A family of long-awaited and newly synthesized kinin antagonists are beginning to be used in these tasks. In addition, other recent advances in the study of kallikreins and kinins have been made using state-of-the-art technologies in molecular genetics and biology, biophysics, synthetic and organo-analytical chemistry, and immunology. Thus, the study of kallikreins and kinins has reached a most exciting point with health-related implications to cardiovascular, metabolic, endocrinologic, inflammatory and malignant diseases. The purpose of this proposal is to request funds to further facilitate these studies by partially supporting the third Gordon Research Conference on Kallikreins and Kinins. This conference, as its predecessors, will serve to further stimulate both new and established investigators to new discovery in this area of endeavor.

激肽释放酶和激肽原酶（产生激肽的酶）是丝氨酸 具有有限和特异性蛋白水解能力的蛋白酶。 存在 一个大的激肽释放酶基因家族（在去年的戈登 会议）;定位位点的多样性，包括：血浆，精子， 外周外分泌腺及其分泌物，肾和肠 上皮细胞，各种脑细胞核，垂体和松果体，红血 细胞膜和其他血液成分，血管壁，如 以及无脊椎动物和细菌中密切相关的酶; “激肽释放酶-激肽”系统只是许多人的范例的可能性 其他激肽释放酶调节的底物产物系统，因为组织 激肽释放酶可以攻击几种新鉴定的底物，（例如，心房 利钠因子前体，载脂蛋白B100）;都是 自1983年戈登会议以来，人们的兴趣明显提高。 现在有人提出，组织激肽释放酶基因家族可能是 负责合成几种密切相关的激肽释放酶， 不同的，但键特异性的蛋白水解活性，调节 许多肽激素的加工。 这个令人兴奋的想法正在酝酿 到目前为止，还没有证据表明组织激肽释放酶 作用于除激肽原以外的任何内源性底物。 数据正在 在许多实验室聚集，解决这个问题，最重要的是， 激肽释放酶功能职责的完整描述 和激肽的关系 一个期待已久的新合成的激肽家族 在这些任务中开始使用拮抗剂。 此外，其他 在激肽释放酶和激肽的研究中已经取得了最新进展， 最先进的分子遗传学和生物学技术， 生物物理学、合成和有机分析化学以及免疫学。 因此，激肽释放酶和激肽的研究已经达到了一个最令人兴奋的点 对心血管，代谢， 内分泌、炎症和恶性疾病。 这样做的目的 建议要求资金，以进一步促进这些研究， 部分支持第三届戈登激肽释放酶研究会议 还有Kinins 本次会议，作为其前身，将进一步 刺激新的和建立的研究人员在这方面的新发现， 奋进的领域。