CELL MEDIATED CALCIFICATION & MATRIX VESICLES CONFERENCE

细胞介导的钙化

基本信息

批准号：
3433756
负责人：
HARRISON CLARKE ANDERSON
金额：
$ 0.5万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
起止时间：
1990-07-10 至 1992-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3433756
关键词：
calcification extracellular matrix travel

项目摘要

This application is for support of an international conference on the mechanism of cell-mediated calcification with special emphasis on matrix vesicles which serve as the initial site of calcification in predentin, developing bone and growth cartilage. Calcification is a fundamental biological process, defects of which underlie many skeletal, dental and calcific diseases. Yet, the mechanism of calcification remains incompletely understood. The conference will assemble an international group of noted scientists, and will conduct a four-day program of presentations and discussions aimed at stimulating research in this area. The scope of the conference will be broad enough to attract scientists with a wide range of interests including the chemistry of bone mineral, the ultrastructure of mineralizing tissues, matrix macromolecules which play a role in mineralization (e.g. lipids, collagen, proteoglycans, calcium-binding matrix molecules and non-collagenous proteins), matrix vesicle membranes and constitutive proteins and enzymes which may promote initial mineralization, the regulation of matrix vesicle biogenesis, and calcific diseases. To foster greater personal interaction and the development of collaborative efforts, the meeting will follow a Gordon Research Conference-type of format with morning and evening sessions and afternoons largely free for informal discussions. Discussion will be further encouraged by limiting the number of papers per session and setting aside time at the end of each session. Poster sessions will provide wider coverage of recent research. Young scientists who submit outstanding abstracts will be considered for Young Investigator Awards, and for reporting their findings at an oral session. The conference is the fifth in a series of international meetings related to matrix vesicles and cell-mediated calcification of which two were held in the United States (1975, 1978), one in Italy (1981) and one in England (1985). It is timely that the conference return to the United States, under the sponsorship of the NIH, as it was in 1978. The central theme will be the broad topic of how cells ultimately control calcification, or lose control with devastating clinical effects upon the host.

该申请是为了支持国际会议细胞介导的钙化机理，特别强调基质囊泡是predentin中钙化的初始位点，发展骨骼和生长软骨。钙化是基本的生物过程，其缺陷是许多骨骼，牙齿和钙化疾病。然而，钙化的机制仍然不完全理解。会议将组成一个著名的国际团体科学家，将进行为期四天的演讲计划，旨在刺激该领域的研究的讨论。范围会议将足够广泛，以吸引科学家兴趣包括骨矿物质的化学，超微结构矿化组织，基质大分子，在矿化（例如脂质，胶原蛋白，蛋白聚糖，钙结合基质分子和非胶原蛋白），基质囊泡膜以及可能促进初始的构成蛋白和酶矿化，基质囊泡生物发生的调节和钙化疾病。促进更多的个人互动和发展协作努力，会议将遵循戈登研究会议类型的格式与早晨和晚上的会议和下午在很大程度上免费进行非正式讨论。讨论将进一步通过限制每个会话的论文数量并搁置每个会话结束时的时间。海报会议将提供更广泛的最近研究的覆盖范围。提交杰出的年轻科学家年轻调查员奖和在口头会议上报告他们的发现。会议是第五次一系列与基质囊泡有关的国际会议和细胞介导的钙化，其中两个在美国举行（1975年，1978年），意大利（1981），英格兰（1985）。这是及时的会议返回美国的赞助 NIH，就像1978年一样。中心主题将是广泛的话题细胞最终如何控制钙化或失去控制对宿主的破坏性临床影响。