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CELL MEDIATED CALCIFICATION & MATRIX VESICLES CONFERENCE

细胞介导的钙化

基本信息

批准号：
3433756
负责人：
HARRISON CLARKE ANDERSON
金额：
$ 0.5万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
起止时间：
1990-07-10 至 1992-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3433756
关键词：
calcification extracellular matrix travel

项目摘要

This application is for support of an international conference on the mechanism of cell-mediated calcification with special emphasis on matrix vesicles which serve as the initial site of calcification in predentin, developing bone and growth cartilage. Calcification is a fundamental biological process, defects of which underlie many skeletal, dental and calcific diseases. Yet, the mechanism of calcification remains incompletely understood. The conference will assemble an international group of noted scientists, and will conduct a four-day program of presentations and discussions aimed at stimulating research in this area. The scope of the conference will be broad enough to attract scientists with a wide range of interests including the chemistry of bone mineral, the ultrastructure of mineralizing tissues, matrix macromolecules which play a role in mineralization (e.g. lipids, collagen, proteoglycans, calcium-binding matrix molecules and non-collagenous proteins), matrix vesicle membranes and constitutive proteins and enzymes which may promote initial mineralization, the regulation of matrix vesicle biogenesis, and calcific diseases. To foster greater personal interaction and the development of collaborative efforts, the meeting will follow a Gordon Research Conference-type of format with morning and evening sessions and afternoons largely free for informal discussions. Discussion will be further encouraged by limiting the number of papers per session and setting aside time at the end of each session. Poster sessions will provide wider coverage of recent research. Young scientists who submit outstanding abstracts will be considered for Young Investigator Awards, and for reporting their findings at an oral session. The conference is the fifth in a series of international meetings related to matrix vesicles and cell-mediated calcification of which two were held in the United States (1975, 1978), one in Italy (1981) and one in England (1985). It is timely that the conference return to the United States, under the sponsorship of the NIH, as it was in 1978. The central theme will be the broad topic of how cells ultimately control calcification, or lose control with devastating clinical effects upon the host.

此申请是为了支持关于该问题的国际会议细胞介导的钙化机制，特别强调基质作为前牙本质钙化初始部位的囊泡，骨骼发育和软骨生长。钙化是根本生物过程，其缺陷是许多骨骼、牙齿和钙化性疾病。然而，钙化的机制仍然不完全明白了。会议将聚集一个国际知名团体科学家，并将进行为期四天的演讲和旨在促进这一领域研究的讨论。范围会议的范围将足以吸引具有广泛领域的科学家兴趣包括骨矿物质的化学、骨的超微结构矿化组织、基质大分子，在矿化（例如脂质、胶原蛋白、蛋白聚糖、钙结合基质分子和非胶原蛋白）、基质囊泡膜以及可能促进初始的组成性蛋白质和酶矿化、基质囊泡生物发生的调节和钙化疾病。促进更多的个人互动和发展协作努力，会议将遵循戈登研究会议类型的形式，包括上午、晚上和下午基本上可以免费进行非正式讨论。讨论将进一步鼓励限制每届会议的论文数量并留出每节课结束时的时间。海报会议将提供更广泛的近期研究的报道。提交优秀青年科学家摘要将被考虑获得青年研究者奖，并在口头会议上报告他们的发现。此次会议是第五届一系列与基质囊泡相关的国际会议细胞介导的钙化，其中两次在美国进行（1975、1978）、意大利一项（1981）和英国一项（1985）。很及时会议将在以下组织的赞助下返回美国 NIH，就像 1978 年一样。中心主题将是广泛的主题细胞如何最终控制钙化，或失去控制对宿主造成毁灭性的临床影响。