CELL MEDIATED CALCIFICATION & MATRIX VESICLES CONFERENCE

本申请书是为了支持一项关于 细胞介导的钙化机制特别侧重于基质 小泡是前牙本质中钙化的初始位置， 发育骨骼和生长软骨。钙化是最基本的 生物过程，其缺陷是许多骨骼、牙齿和 钙化性疾病。然而，钙化的机制仍然不完全。 明白了。这次会议将召集一个著名的国际小组 科学家，并将进行为期四天的演讲和 旨在促进这一领域研究的讨论。的范围 会议将足够广泛，以吸引范围广泛的科学家 兴趣包括骨矿物的化学，骨的超微结构 矿化组织，基质大分子，在 矿化(如脂类、胶原蛋白、蛋白多糖、钙结合 基质分子和非胶原蛋白)、基质泡泡膜 和组成蛋白和酶，它们可能促进初始 矿化、基质泡生物发生的调控和钙化 疾病。促进更多的个人互动和发展 合作努力，会议将遵循戈登研究 会议形式，包括上午和晚上会议以及下午会议 很大程度上可以自由地进行非正式讨论。我们将进一步讨论。 通过限制每届会议的论文数量并留出 每个会话结束时的时间。海报会议将提供更广泛的 对最近研究的报道。提交杰出论文的青年科学家 摘要将被考虑参加青年研究员奖，以及 在口头会议上报告他们的发现。这次会议是第五届 一系列与基质囊泡和基质囊泡有关的国际会议 细胞介导的钙化，其中两项在美国举行 (1975,1978)，一个在意大利(1981)，一个在英国(1985)。它来得正是时候 会议将返回美国，由以下组织赞助 美国国立卫生研究院，就像1978年一样。中心主题将是 细胞如何最终控制钙化，或失去对 对宿主造成毁灭性的临床影响。

This application is for support of an international conference on the mechanism of cell-mediated calcification with special emphasis on matrix vesicles which serve as the initial site of calcification in predentin, developing bone and growth cartilage. Calcification is a fundamental biological process, defects of which underlie many skeletal, dental and calcific diseases. Yet, the mechanism of calcification remains incompletely understood. The conference will assemble an international group of noted scientists, and will conduct a four-day program of presentations and discussions aimed at stimulating research in this area. The scope of the conference will be broad enough to attract scientists with a wide range of interests including the chemistry of bone mineral, the ultrastructure of mineralizing tissues, matrix macromolecules which play a role in mineralization (e.g. lipids, collagen, proteoglycans, calcium-binding matrix molecules and non-collagenous proteins), matrix vesicle membranes and constitutive proteins and enzymes which may promote initial mineralization, the regulation of matrix vesicle biogenesis, and calcific diseases. To foster greater personal interaction and the development of collaborative efforts, the meeting will follow a Gordon Research Conference-type of format with morning and evening sessions and afternoons largely free for informal discussions. Discussion will be further encouraged by limiting the number of papers per session and setting aside time at the end of each session. Poster sessions will provide wider coverage of recent research. Young scientists who submit outstanding abstracts will be considered for Young Investigator Awards, and for reporting their findings at an oral session. The conference is the fifth in a series of international meetings related to matrix vesicles and cell-mediated calcification of which two were held in the United States (1975, 1978), one in Italy (1981) and one in England (1985). It is timely that the conference return to the United States, under the sponsorship of the NIH, as it was in 1978. The central theme will be the broad topic of how cells ultimately control calcification, or lose control with devastating clinical effects upon the host.