CELL MEDIATED CALCIFICATION & MATRIX VESICLES CONFERENCE

此申请是为了支持一个关于 细胞介导的钙化机制，特别强调基质 囊泡作为前牙本质钙化的初始部位， 骨骼发育和软骨生长。钙化是一种基本的 生物过程，其缺陷是许多骨骼，牙齿和 钙化性疾病然而，钙化的机制仍然不完全 明白会议将召集一个国际知名的 科学家，并将进行为期四天的演讲计划， 旨在促进这一领域研究的讨论。的范围 会议将足够广泛，以吸引科学家与广泛的 兴趣包括骨矿物质的化学， 矿化组织，基质大分子， 矿化（如脂质、胶原蛋白、蛋白聚糖、钙结合蛋白） 基质分子和非胶原蛋白）、基质囊泡膜 和组成蛋白质和酶，可以促进初始 矿化、基质囊泡生物发生的调节和钙化 疾病促进更多的个人互动和发展 合作努力，会议将遵循戈登研究 会议形式，上午、晚上和下午各举行一次会议 大部分是自由的，可以进行非正式讨论。讨论将进一步 鼓励限制每届会议的论文数量， 时间在每一次会议结束时。海报会议将提供更广泛的 最近的研究报道。年轻的科学家们提交了杰出的 摘要将被视为青年研究者奖，并为 在口头会议上报告他们的发现。会议是第五次在 一系列与基质囊泡有关的国际会议， 细胞介导的钙化，其中两个在美国举行 (1975，1978年），一个在意大利（1981年），一个在英国（1985年）。正当其时 会议回到美国，由 和1978年一样中心主题将是广泛的主题， 细胞如何最终控制钙化，或失去控制， 对宿主造成毁灭性的临床影响

This application is for support of an international conference on the mechanism of cell-mediated calcification with special emphasis on matrix vesicles which serve as the initial site of calcification in predentin, developing bone and growth cartilage. Calcification is a fundamental biological process, defects of which underlie many skeletal, dental and calcific diseases. Yet, the mechanism of calcification remains incompletely understood. The conference will assemble an international group of noted scientists, and will conduct a four-day program of presentations and discussions aimed at stimulating research in this area. The scope of the conference will be broad enough to attract scientists with a wide range of interests including the chemistry of bone mineral, the ultrastructure of mineralizing tissues, matrix macromolecules which play a role in mineralization (e.g. lipids, collagen, proteoglycans, calcium-binding matrix molecules and non-collagenous proteins), matrix vesicle membranes and constitutive proteins and enzymes which may promote initial mineralization, the regulation of matrix vesicle biogenesis, and calcific diseases. To foster greater personal interaction and the development of collaborative efforts, the meeting will follow a Gordon Research Conference-type of format with morning and evening sessions and afternoons largely free for informal discussions. Discussion will be further encouraged by limiting the number of papers per session and setting aside time at the end of each session. Poster sessions will provide wider coverage of recent research. Young scientists who submit outstanding abstracts will be considered for Young Investigator Awards, and for reporting their findings at an oral session. The conference is the fifth in a series of international meetings related to matrix vesicles and cell-mediated calcification of which two were held in the United States (1975, 1978), one in Italy (1981) and one in England (1985). It is timely that the conference return to the United States, under the sponsorship of the NIH, as it was in 1978. The central theme will be the broad topic of how cells ultimately control calcification, or lose control with devastating clinical effects upon the host.