FIRST INTERNATIONAL CONFERENCE ON GROWTH PLATE

首届国际增长板块会议

• 批准号: 6045459
• 负责人: HARRISON CLARKE ANDERSON
• 金额: $ 2.3万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6045459
• 关键词: bone plates; chondrocytes; dental development; dental research; epiphysis; meeting /conference /symposium; normal ossification; travel

Support is requested for the First International Conference on the Growth Plate to be held March 29-April 1, 2000 in San Antonio, Texas. This new conference will serve as the successor to five earlier conferences devoted to the study of matrix vesicle calcification. The focus on the growth plate was chosen since it incorporates not only the interests of investigators studying matrix vesicles but also serves as a focus for the research activities of a very diverse group of biomedical researchers. This group of individuals includes dental and orthopedic researchers examining the regulation of craniofacial growth and mineralization; molecular biologists probing skeletal morphogenesis; developmental biologists studying regulation of the cell cycle, angiogenesis, and apoptosis; biochemists studying the function of collagenous, non-collagenous and growth factor components of the cartilage matrix; and mineral biologists investigating the physical chemistry of the bone mineral and the interaction of matrix and mineral components during the calcification process. Additionally the plate is the focus of attention of pathologists, endocrinologists, orthopedists, pediatric specialists, orthodontists, oral surgeons and clinical geneticists who investigate abnormalities of the growth plate leading to craniofacial anomalies, skeletal dysplasias, scoliosis and problems linked to hypomineralization. The conference on the growth plate is predicted to attract approximately 250 investigators from these diverse fields. Specific topics to be discussed include: a) patterning, morphogens and regulation of the epiphysial phenotype, b) regulation of chondrocyte proliferation and maturation, c) structure and organization of the growth plate; d) matrix vesicle and cell mediated mineralization, e) terminal events at the chondro-osseous junction, and f) genetic mutations and craniofacial and orthopedic anomalies. In both formal and informal sessions, time will be spent correlating these fundamental studies with clinical problems associated with developmental anomalies or dysfunction. Time will also be devoted to addressing the problems of molecular-based therapies.

请求支持第一次国际会议 生长板将于20​​00年3月29日至4月1日在德克萨斯州圣安东尼奥举行。这个新 会议将担任五次致力于的五个会议的继任者 基质囊泡钙化的研究。对生长板的关注是 选择，因为它不仅包含了研究人员的利益 基质囊泡，但也是研究活动的重点 非常多样化的生物医学研究人员。这组个人 包括检查调节的牙科和骨科研究人员 颅面生长和矿化；分子生物学家探测骨骼 形态发生；研究细胞周期调节的发育生物学家， 血管生成和凋亡；研究胶原功能的生化主义者 软骨基质的非胶原和生长因子成分；和 矿物生物学家研究了骨矿物质和 钙化过程中基质和矿物成分的相互作用 过程。此外，板是病理学家注意的重点， 内分泌学家，骨科医生，儿科专家，正畸医生，口腔 研究生长异常的外科医生和临床遗传学家 导致颅面异常，骨骼发育不良，脊柱侧弯和 与低矿化有关的问题。生长板的会议是 预计将吸引来自这些不同领域的大约250名研究人员。 要讨论的特定主题包括：a）图案，形态和形式和 骨表型的调节，b）软骨细胞的调节 增殖和成熟，c）增长的结构和组织 盘子; d）基质囊泡和细胞介导的矿化，e）末端事件 在软骨骨交界处，f）基因突变和颅面和颅面 骨科异常。在正式和非正式会议中，时间都将花费时间 将这些基本研究与与之相关的临床问题相关联 发育异常或功能障碍。时间也将致力于解决 基于分子的疗法的问题。