FIRST INTERNATIONAL CONFERENCE ON GROWTH PLATE

请求为第一次国际会议提供支助 Growth Platform将于2000年3月29日至4月1日在德克萨斯州圣安东尼奥举行。这是一项新的 会议将作为前五次会议的后续会议，致力于 基质囊泡钙化的研究。对增长板块的关注重点是 之所以选择它，是因为它不仅包含了研究人员的兴趣 基质囊泡，也是一个研究活动的焦点 各式各样的生物医学研究人员。这群人 包括牙科和整形外科研究人员检查 颅面生长和矿化；分子生物学家探测骨骼 形态发生学；研究细胞周期调控的发育生物学家， 血管生成和细胞凋亡；生物化学家研究胶原的功能， 软骨基质的非胶原和生长因子成分；以及 矿物生物学家研究骨骼矿物的物理化学和 钙化过程中基质与矿物成分的相互作用 进程。此外，钢板也是病理学家关注的焦点， 内分泌学家、骨科医生、儿科专家、正畸医生、口腔医生 研究生长异常的外科医生和临床遗传学家 导致头面部畸形、骨骼发育不良、脊柱侧弯和 与矿化不足有关的问题。关于增长板块的会议是 预计将吸引来自这些不同领域的约250名调查人员。 将讨论的具体主题包括：a)图案化、形态生成和 骨痂表型的调节，b)软骨细胞的调节 增殖和成熟，c)生长的结构和组织 板块；d)基质小泡和细胞介导的矿化；e)终端事件 在软骨-骨性交界处，以及f)基因突变和颅面部和 整形外科畸形。在正式和非正式会议上，都将花费时间 将这些基础研究与临床问题联系起来 发育异常发育异常或功能障碍时间也将用来解决 基于分子的疗法的问题。

Support is requested for the First International Conference on the Growth Plate to be held March 29-April 1, 2000 in San Antonio, Texas. This new conference will serve as the successor to five earlier conferences devoted to the study of matrix vesicle calcification. The focus on the growth plate was chosen since it incorporates not only the interests of investigators studying matrix vesicles but also serves as a focus for the research activities of a very diverse group of biomedical researchers. This group of individuals includes dental and orthopedic researchers examining the regulation of craniofacial growth and mineralization; molecular biologists probing skeletal morphogenesis; developmental biologists studying regulation of the cell cycle, angiogenesis, and apoptosis; biochemists studying the function of collagenous, non-collagenous and growth factor components of the cartilage matrix; and mineral biologists investigating the physical chemistry of the bone mineral and the interaction of matrix and mineral components during the calcification process. Additionally the plate is the focus of attention of pathologists, endocrinologists, orthopedists, pediatric specialists, orthodontists, oral surgeons and clinical geneticists who investigate abnormalities of the growth plate leading to craniofacial anomalies, skeletal dysplasias, scoliosis and problems linked to hypomineralization. The conference on the growth plate is predicted to attract approximately 250 investigators from these diverse fields. Specific topics to be discussed include: a) patterning, morphogens and regulation of the epiphysial phenotype, b) regulation of chondrocyte proliferation and maturation, c) structure and organization of the growth plate; d) matrix vesicle and cell mediated mineralization, e) terminal events at the chondro-osseous junction, and f) genetic mutations and craniofacial and orthopedic anomalies. In both formal and informal sessions, time will be spent correlating these fundamental studies with clinical problems associated with developmental anomalies or dysfunction. Time will also be devoted to addressing the problems of molecular-based therapies.