SIXTH INTERNATIONAL CONFERENCE ON THE SODIUM PUMP

一个关于钠泵的公开国际会议计划于 1990年9月5日至9日，在马萨诸塞州伍兹霍尔的海洋生物实验室。 这是一系列三年期会议中的第六次会议， 美国，第一次是由普通生理学家协会赞助的。其 会议记录将由洛克菲勒大学出版社出版， 《普通生理学杂志》（Journal of General Physiology）研究的步伐 钠泵正在加速，特别是在分子 生物学和结构-功能关系，电荷转移和 电压依赖性，以及前稳态动力学和离子吸留。的 会议将为这些尚未（尚未） 在为期五天的密集讨论中， 并将他们的结论传播给更广泛的受众， 参与者或协会成员，特别是同事 研究E1-E2转运ATP酶家族的其他成员。五大 主题将涵盖：（1）分子生物学的钠泵，异构体， 调控，并设计突变体;（2）结构研究，既经验 （二维晶体、化学修饰和位置映射）和 理论（来自一级序列）;（3）构象变化和离子 闭塞，从内在和外在信号以及从 同位素“捕获”;（4）详细的稳态和稳态前（“快”） 泵循环中各种模式和中间步骤的动力学;以及 (5)产电性和电压依赖性，重点是识别 周期中的电压敏感（电荷移位）步骤。此外，委员会认为， 如果新发展证明有必要，可能会举办一个关于内源泵的讲习班 监管部门27个，包括13个非美国人，发言人一直 邀请他们对自己的工作进行全面的批判性评论， 这是其他人的，并为诉讼程序写了一章。讲座 会议将在五个上午举行。剩下的时间将 专门举办与会议主题有关的海报会议，24小时 access. H.C.教授Khorana同意发表主旨演讲。的 会议记录将在会议后10个月内公布，包括 根据主席的介绍， 讲座，以及相关海报的短纸版本。

An open International Conference on the Sodium Pump is planned for September 5-9, 1990, at the Marine Biological Laboratory, Woods Hole, MA. It is the sixth in a series of triennial meetings, the third held in the U.S., and the first sponsored by the Society of General Physiologists. Its proceedings will be published by Rockefeller University Press, and distributed with the Journal of General Physiology. The pace of research on the sodium pump is accelerating, especially in the areas of molecular biology and structure-function relationships, charge translocation and voltage dependence, and presteady-state kinetics and ion occlusion. The conference will offer a timely opportunity for experts in these not (yet) overlapping fields to compare notes in an intensive five-day discussion, and to disseminate their conclusions to an audience much wider than the participants or the Society's membership, in particular, to colleagues working on other members of the E1-E2 transport ATPase family. Five major themes will be covered: (1) Molecular Biology of the Sodium Pump, isoforms, regulation, and designed mutants; (2) Structural Studies both empirical (two-dimensional crystals, chemical modification, and site mapping) and theoretical (from primary sequences); (3) Conformational Changes and Ion Occlusion, as measured from intrinsic and extrinsic signals and from isotope "trapping"; (4) Detailed steady-state and presteady-state ('fast') kinetics of the various modes and intermediate steps in the pump cycle; and (5) Electrogenicity and voltage dependence with emphasis on identifying the voltage sensitive (charge translocating) step(s) in the cycle. Furthermore, if new developments justify it, a Workshop may be hold on endogenous pump regulators. Twenty-seven, including thirteen non-U.S., speakers have been invited to present comprehensive critical reviews of their own work and that of others, and to write a chapter for the proceedings. The lecture program will be held during five morning sessions. The remaining time will be devoted to poster sessions related to the meeting's themes, with 24-h access. Prof. H.C. Khorana has agreed to deliver the keynote address. The proceedings, to be published within 10 months of the meeting, will consist of chapters corresponding to the chairmen's introductions and invited lectures, and of short-paper versions of the relevant posters.