GORDON CONFERENCE--ATHEROSCLEROSIS 1993

此应用程序是部分支持第11戈登研究 关于动脉粥样硬化的会议将在新的金博尔联合学院举行 汉普郡，1993年6月21日至25日。 这次国际会议， 每两年举行一次，将提供最令人兴奋的概述 脂蛋白和血管细胞生物学的最新进展， 与动脉粥样硬化有关。 基本分子机制的进步和 定义特定分子在体内作用的新模型将是 包括. 计划举办九次会议，内容包括： 脂蛋白生物学：氧化低密度脂蛋白的新活性; 巨噬细胞和内皮NO合酶系统;新开发的 转基因模型;高脂血症的基因治疗。 内皮活化和细胞粘附：白细胞粘附的分子基础 内皮细胞相互作用;整合素活化机制;转基因 模型和新的药物，以确定每一个的重要性， 体内系统。 生长因子和细胞因子的作用：表达的调节; 动脉粥样硬化中迁移和增殖细胞的鉴定;基因 用于定义体内作用的递送和转基因模型。 凝血因子在动脉粥样硬化形成中的作用：病理学研究; 凝血酶在斑块细胞活化中的作用;确定凝血酶作用的体内研究 凝血酶在增殖反应中的作用。

This application is for partial support of the 11th Gordon Research Conference on Atherosclerosis to be held at Kimball Union Academy, New Hampshire, June 21-25, 1993. This international conference, which is held every two years, will provide an overview of the most exciting recent developments in lipoprotein and vascular cell biology as they relate to atherogenesis. Both basic molecular mechanistic advances and new models for defining the role of particular molecules in vivo will be included. Nine sessions are planned and will cover: Lipoprotein biology: New activities of oxidized LDL; Relationship to the macrophage and endothelial NO synthase systems; Newly developed transgenic models; Gene therapy for hyperlipidemia. Endothelial activation and cell adhesion: Molecular basis for leukocyte- endothelial interactions; Mechanisms of integrin activation; Transgenic models and novel pharmaceuticals for defining the importance of each system in vivo. Role of growth factors and cytokines: Regulation of expression; Identification of migrating and proliferating cells in atheroma; Gene delivery and transgenic models for defining in vivo role. Coagulation factors in atherogenesis: Pathologic studies; Role of thrombin in plaque cell activation; In vivo studies defining the role of thrombin in proliferative responses.