GORDON CONFERENCE--ELASTIN

弹性蛋白是身体的一种主要结构蛋白，赋予身体 组织的延伸性和弹性反冲的特性 它被找到了。弹性蛋白在血管、肺、 和一些韧带，但也以较小的数量存在于各种 其他组织包括皮肤、子宫、骨膜、心肌和 弹性软骨。因为它对身体的重要贡献 这些组织的性质和生理功能，在 弹性蛋白的合成、组装和降解在几个方面都很重要 具有重大社会意义的疾病，包括肺气肿、肺部疾病和 系统性高血压，动脉粥样硬化，以及在一些可遗传和 获得性皮肤病。 本申请寻求对第八届戈登研究半年期的支持 关于弹性蛋白的会议。这次会议将整合新的信息 弹性蛋白及其转录调控的分子生物学研究进展 弹性蛋白相关蛋白及其调控因子的最新研究结果 在细胞和组织水平产生弹性蛋白，提供 关于防治机制的现有知识的全面总结 这种强烈发育调节的蛋白质的合成。在……里面 此外，关于微纤维复合体及其作用的新信息 细胞表面弹性蛋白结合蛋白将导致对 弹性纤维的胞外组装机制。这个 会议还将讨论人员更替和重整机制。 弹性基质以及内源性组织的性质和作用 弹力酶活性和弹力酶抑制剂在发育和发育中的作用 弹性组织的病理学。弹性蛋白合成的异常， 在肺气肿、高血压、 动脉粥样硬化、皮肤病和其他病理情况 将继续为监管这些问题提供重要见解 流程。 关于弹性蛋白的戈登会议，每两年举行一次 自1979年以来，已成为各国调查人员的重要会议 全世界对形态、物理化学、 弹性蛋白和弹性蛋白的生物化学、分子生物学和病理学 纸巾。历届会议的与会者都热情地同意 本次会议为以下各方提供了最重要的交流论坛 这一领域的调查人员。拟议中的会议将把 来自不同学科的基础科学家介绍和讨论 关于合成、组装和降解的最新信息 弹性蛋白。与过去几年一样，这些审议将产生新的 开展合作研究，开辟新的研究途径 重要的结缔组织蛋白。

Elastin is a major structural protein of the body, imparting the physical properties of extensibility and elastic recoil to the tissues in which it is found. Elastin is particularly abundant in blood vessels, lung, and some ligaments, but is also present in smaller amounts in a variety of other tissue including skin, uterus, periosteum, myocardium, and elastic cartilage. Because of its crucial contribution to the physical properties and physiological function of such tissues, alterations in elastin synthesis, assembly, and degradation are of importance in several diseases of major social significance, including emphysema, pulmonary and systemic hypertension, atherosclerosis, and in some heritable and acquired diseases of the skin. This application seeks support for the eighth bi-annual Gordon Research Conference on Elastin. This conference will integrate new information on the molecular biology and transcriptional regulation of elastin and elastin-associated proteins with recent results on factors modulating elastin production at the cell and tissue level, providing a comprehensive summary of current knowledge of mechanisms for the control of synthesis of this strongly developmentally regulated protein. In addition, new information on the microfibrillar complex and the role of the cell surface elastin-binding protein will result in new insights into the mechanism of extracellular assembly of the elastic fibre. The conference will also address the mechanisms of turnover and remodelling of the elastic matrix, and the nature and role of endogenous tissues elastase activity and elastase inhibitors in the development and pathology of elastic tissues. Aberrations of elastin synthesis, assembly, and degradation occurring in emphysema, hypertension, atherosclerosis, cutaneous diseases and other pathological situations will continue to provide important insights into the regulation of these processes. The Gordon Conference on Elastin, which has been held every second year since 1979, has become a major meeting for investigators from all over the world with an interest in the morphology, physical chemistry, biochemistry, molecular biology and pathology of elastin and elastic tissues. Attendees of previous conferences enthusiastically agree that this meeting provides the most important forum for communications among investigators in this field. The proposed meeting will bring together basic scientists from a variety of disciplines to present and discuss the most recent information on synthesis, assembly and degradation of elastin. As in past years, these deliberations will result in new collaborative studies and stimulate new avenues of investigation of this important connective tissue protein.