1993 GORDON RESEARCH CONFERENCE ON WOUND REPAIR

1993 年戈登伤口修复研究会议

• 批准号: 3435206
• 负责人: Jeffrey M. Davidson
• 金额: $ 1.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1994-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435206
• 关键词: meeting /conference /symposium; travel; wound healing

The purpose of this application is to seek support for a new Gordon Research Conference on Wound Repair. The overall design of this conference was recently approved by the Gordon Research Conference advisory board and the meeting is presently scheduled for June 13 - 18, 1993. The field of wound repair has undergone a rapid phase of modernization in the face of recent discoveries in the area of intracellular signaling and cell matrix interactions. In the last five years, we have witnessed the formation of national and international societies devoted to this topic and an expanding literature in the discipline. While a number of symposia convene to address topics in wound repair, the Gordon Research Conference provides a unique and intimate atmosphere for the exchange of state-of-the-art information on the biology of this phenomenon . Wound repair is both a clinical problem and a biological discipline. It is a process which proceeds from hemostasis and inflammation through the formation of a temporary granulation tissue characterized by fibroplasia and angiogenesis, to a healed wound or scar. Obvious pathological changes during the course of wound repair include, on the one hand extensive fibrosis, and on the other hand various forms of ulceration. Wound repair is hardly a process confined to the cutaneous domain, but is most frequently studied in experimental models using skin lesions. Other specialized organs and tissues show important variations on the repair theme and need to be considered in the broadest context of wound repair. This conference was initially conceived in 1990 with the hope of bringing together basic scientists, clinical scientists and industry into a form where informal contacts could be optimized around a core of state-of-the-art lectures. The conference, as outlined, will deal with soluble and insoluble mediators of the repair process, specialized repair processes in tissues such as bone, lung, and liver, the control of excess fibroplasia, and the biological basis of nonhealing wounds. A special session on Thursday evening of the conference will be devoted a more historical view of the concepts of regeneration that have developed over the last four decades. This conference is designed, in particular, to encourage persons not directly involved in wound repair to the area because of important collateral interests. Important areas to be considered include mechanisms of growth factor and lymphokine action, the regulation of matrix biosynthesis, and the nature of stem cell populations participating in wound healing in various organs. This conference is expected to have, 120 to 130 attendees, with balanced participation from academia, government and industry. Wound repair is a complex biological phenomenon. Treatment modalities, even using the most sophisticated molecular approaches, will not succeed unless a closer connection is made between the biological reality of the wound and the biochemical behavior of participating cell populations. The Gordon Research Conference, represents an important opportunity to create an ongoing venue for discussions on the biology of wound repair.

本申请的目的是寻求支持新的戈登 伤口修复研究会议。 整个设计 会议最近获得了戈登研究会议的批准 顾问委员会和会议目前定于6月13日至18日 1993年。伤口修复领域经历了一个快速的阶段 面对最近发现的现代化 细胞内信号传导和细胞基质相互作用。 在最后五个 几年，我们目睹了国家和国际的形成 致力于这个主题的社会和文学的不断扩展 纪律。 虽然许多研讨会召集，以解决 伤口维修，戈登研究会议提供了独特的和 交换最新信息的亲密气氛 这种现象的生物学。伤口修复都是临床问题 和一门生物学纪律。 这是一个从 通过临时形成的止血和炎症 以纤维状和血管生成为特征的肉芽组织 治愈伤口或疤痕。 在此过程中明显的病理变化 伤口修复包括，一方面是广泛的纤维化，在 另一方面，各种形式的溃疡。 伤口修复几乎不是一个过程 仅限于皮肤领域，但最常研究 使用皮肤病变的实验模型。 其他专门的器官 组织在维修主题上表现出重要的变化，需要 在伤口修复的最广泛背景下考虑。 这次会议是 最初在1990年构思，希望将基本 科学家，临床科学家和工业成立非正式的形式 可以围绕最先进的讲座核心优化联系人。 概述的会议将处理可溶性和不溶性 维修过程的介体，组织中的专门维修过程 例如骨骼，肺和肝脏，控制过多的纤维浮肿，以及 非治疗伤口的生物基础。 星期四的特别会议 会议的傍晚将成为更历史的观点 在过去的四十年中，再生的概念已经发展。 该会议尤其是为了鼓励人们而不是 由于重要的 抵押利益。 要考虑的重要领域包括 生长因子和淋巴动物作用的机制，调节 基质生物合成和干细胞种群的性质 参加各种器官的伤口愈合。 这次会议是 预计将有120至130名与会者，并有均衡的参与 学术，政府和工业。 伤口修复是一种复杂的生物学 现象。 即使使用最复杂的治疗方式 分子方法，除非建立更紧密的联系，否则不会成功 在伤口的生物学现实与生化行为之间 参与细胞群体。 戈登研究会议， 代表了创建正在进行的场地的重要机会 关于伤口修复生物学的讨论。