1993 GORDON RESEARCH CONFERENCE ON WOUND REPAIR

1993 年戈登伤口修复研究会议

• 批准号: 3435206
• 负责人: Jeffrey M. Davidson
• 金额: $ 1.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1994-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435206
• 关键词: meeting /conference /symposium; travel; wound healing

The purpose of this application is to seek support for a new Gordon Research Conference on Wound Repair. The overall design of this conference was recently approved by the Gordon Research Conference advisory board and the meeting is presently scheduled for June 13 - 18, 1993. The field of wound repair has undergone a rapid phase of modernization in the face of recent discoveries in the area of intracellular signaling and cell matrix interactions. In the last five years, we have witnessed the formation of national and international societies devoted to this topic and an expanding literature in the discipline. While a number of symposia convene to address topics in wound repair, the Gordon Research Conference provides a unique and intimate atmosphere for the exchange of state-of-the-art information on the biology of this phenomenon . Wound repair is both a clinical problem and a biological discipline. It is a process which proceeds from hemostasis and inflammation through the formation of a temporary granulation tissue characterized by fibroplasia and angiogenesis, to a healed wound or scar. Obvious pathological changes during the course of wound repair include, on the one hand extensive fibrosis, and on the other hand various forms of ulceration. Wound repair is hardly a process confined to the cutaneous domain, but is most frequently studied in experimental models using skin lesions. Other specialized organs and tissues show important variations on the repair theme and need to be considered in the broadest context of wound repair. This conference was initially conceived in 1990 with the hope of bringing together basic scientists, clinical scientists and industry into a form where informal contacts could be optimized around a core of state-of-the-art lectures. The conference, as outlined, will deal with soluble and insoluble mediators of the repair process, specialized repair processes in tissues such as bone, lung, and liver, the control of excess fibroplasia, and the biological basis of nonhealing wounds. A special session on Thursday evening of the conference will be devoted a more historical view of the concepts of regeneration that have developed over the last four decades. This conference is designed, in particular, to encourage persons not directly involved in wound repair to the area because of important collateral interests. Important areas to be considered include mechanisms of growth factor and lymphokine action, the regulation of matrix biosynthesis, and the nature of stem cell populations participating in wound healing in various organs. This conference is expected to have, 120 to 130 attendees, with balanced participation from academia, government and industry. Wound repair is a complex biological phenomenon. Treatment modalities, even using the most sophisticated molecular approaches, will not succeed unless a closer connection is made between the biological reality of the wound and the biochemical behavior of participating cell populations. The Gordon Research Conference, represents an important opportunity to create an ongoing venue for discussions on the biology of wound repair.

这个应用程序的目的是为新戈登寻求支持 伤口修复研究会议。这款车的总体设计 会议最近获得了戈登研究会议的批准 顾问委员会和会议目前定于6月13日至18日举行， 1993年。创伤修复领域经历了一个快速阶段 面对最近在以下领域的发现，实现现代化 细胞内信号和细胞基质的相互作用。在过去的五年中 多年来，我们见证了国家和国际关系的形成 致力于这一主题的社会和不断扩大的文学 纪律。与此同时，一些研讨会聚集在一起讨论 伤口修复，戈登研究会议提供了一个独特的 为交流最先进的信息而营造的亲密氛围 这一现象的生物学特征。伤口修复既是一个临床问题，也是一个 也是一门生物学科。这是一个过程，它是从 止血和炎症通过形成暂时性的 以纤维增生和血管生成为特征的肉芽组织 愈合的伤口或疤痕。发病过程中有明显的病理改变。 伤口修复一方面包括广泛的纤维化，另一方面包括 另一方面，各种形式的溃疡。伤口修复几乎不是一个过程 局限于皮肤领域，但最常在 使用皮肤损伤的实验模型。其他专门机构和 纸巾在修复主题上表现出重要的变化，需要 从最广泛的伤口修复角度来考虑。这次会议是 最初构思于1990年，希望将基本的 科学家、临床科学家和产业界形成一种非正式的形式 联系可以围绕最先进的讲座的核心进行优化。 正如所概述的那样，会议将讨论可溶和不可溶的问题 修复过程的中介，组织中的特殊修复过程 如骨、肺和肝，控制过度纤维增生，以及 无法愈合的伤口的生物学基础。周四的特别会议 大会的当晚将用更多的历史观点来看待 在过去的四十年里发展起来的再生的概念。 这次会议的目的尤其是鼓励那些没有 直接参与伤口修复的区域，因为重要 附带权益。需要考虑的重要领域包括 生长因子和淋巴因子的作用机制、调节 基质生物合成和干细胞群体的性质 参与各种器官的伤口愈合。这次会议是 预计将有120至130名与会者，来自 学术界、政府和工业界。伤口修复是一个复杂的生物学过程。 现象。治疗方式，即使使用最复杂的 分子方法，除非建立更紧密的联系，否则不会成功 在伤口的生物真实性和生化行为之间 参与细胞群体的数量。戈登研究会议， 代表着一个重要的机会，可以为 关于伤口修复生物学的讨论。