INHIBITORS OF HEMATOPOIESIS

造血抑制剂

• 批准号: 3434747
• 负责人: Nicholas Dainiak
• 金额: $ 1.5万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434747
• 关键词: genetic regulation; growth factor; growth factor receptors; hematopoiesis; inhibitor /antagonist; meeting /conference /symposium; travel

This Symposium is scheduled to take place over four days and to address the following specific areas: (1) molecular biology of negative regulators, including inhibition of gene activation, antisense strategies to suppression of DNA and RNA synthesis and gene inactivation by homologous recombination; (2) cellular biology of negative regulators, including description and characterization of negative growth factor inhibitory molecules and inactivation of growth factor receptors; and (3) in vivo effects of negative regulators, including viral suppression of hematopoiesis, expression of "silencer" genes and inactivation of growth factors in transgenic animals, and clinical effects of cell cycle inhibitors in hemoglobinopathies and other disorders of hematopoiesis. In addition to plenary session presentations, workshops and poster sessions will provide the opportunity for young investigators to present data pertaining to each of these topics. Our long-term objectives is to review and explore novel approaches to understanding the regulation of hematopoiesis and to investigating the potential application of negative regulators of the control of hematopoiesis in vivo.

本次研讨会计划为期四天， 具体包括以下几个方面：（1）分子生物学阴性 调节剂，包括抑制基因激活，反义策略 抑制DNA和RNA合成和基因失活， 同源重组;（2）负调节因子的细胞生物学， 包括负生长因子的描述和表征 抑制分子和生长因子受体的失活;和（3） 负调节因子的体内作用，包括病毒抑制 造血、“沉默者”基因表达和生长失活 转基因动物中的因子和细胞周期的临床效应 血红蛋白病和其他造血障碍的抑制剂。 除了全体会议发言、讲习班和海报外， 会议将为年轻的研究人员提供机会， 与这些主题相关的数据。 我们的长远目标是 审查和探索新的方法来了解监管 造血和调查的潜在应用负 体内造血调控的调节剂。