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• 批准号: 3433791
• 负责人: WILLIAM P AREND
• 金额: $ 1万
• 依托单位: KEYSTONE CENTER
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-31 至 1993-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3433791
• 关键词: cellular pathology; cytokine; cytokine receptors; meeting /conference /symposium; molecular pathology; rheumatoid arthritis; skeletal disorder chemotherapy; travel

This Keystone Symposium will offer two concurrent meetings: "Cytokines and Cytokine Receptors: From Cloning to the Clinic" and "Molecular Mechanisms in Rheumatoid Arthritis and Related Diseases". Many important advances have been made in both of these areas of basic research over the past two years making these meetings extremely timely. These meetings are highly multidisciplinary, bringing together investigators from academia and industry representing the research disciplines of cell biology, molecular biology, immunology and biochemistry, and the clinical disciplines of hematology and rheumatology. These meetings are intended to bring together scientists who are working in competing areas and may represent different points of view. The prime objective is to present new and recent research findings that will stimulate cross-fertilization among basic and clinical investigators sharing a common interest in cytokines and mechanisms of human diseases. The meeting on "Cytokines and Cytokine Receptors" will focus on novel cytokine-controlled systems of cellular proliferation and differentiation. Areas to be emphasized include cytokine control of hematopoiesis and lymphopoiesis, mechanisms of signal transduction, and cytokine influence on both gene regulation and expression. The meeting on "Molecular Mechanisms in Rheumatoid Arthritis and Related Diseases" will emphasize the immunologic and inflammatory mechanisms that induce and perpetuate a variety of acute and chronic human diseases. Topics to be discussed include the role of environmental factors, mechanisms of genetic predisposition, T and B cell abnormalities and adhesion molecules. An important emphasis of both meetings will be on the development of new therapeutic approaches to human disease. Joint sessions will be held on recent developments in the inhibition of TNF or IL-1 action. These sessions will discuss the latest developments in the basic biology of the IL-1ra receptor antagonist, soluble IL- 1 receptors, soluble TNF receptors and antibodies to TNF. Additional presentations will provide up-to-date information on the results of clinical trials with each of these reagents. Other new forms of therapy to be discussed will include interference with T lymphocyte function through Monoclonal antibodies, peptides or vaccination, and the use of recombinant cytokines. Thus, these two concurrent Keystone symposia offer an opportunity for a unique scientific forum with interactions. between basic and clinical investigators interested in cells and cytokines in human hematologic, immunologic and inflammatory diseases.

本次Keystone研讨会将同时举行两场会议：“细胞因子 和细胞因子受体：从克隆到临床“和”分子 类风湿性关节炎及相关疾病的发病机制 在这两个基础研究领域都取得了进展 在过去的两年里，这些会议非常及时。这些会议 是高度多学科的，汇集了来自 代表细胞研究学科的学术界和产业界 生物学、分子生物学、免疫学和生化，以及临床 血液学和风湿学的学科。这些会议的目的是 将在相互竞争的领域工作的科学家聚集在一起，可能 代表了不同的观点。主要目标是展示 新的和最新的研究发现将刺激交叉受精 在基础和临床研究人员中有共同的兴趣 细胞因子与人类疾病的发病机制。 关于“细胞因子和细胞因子受体”的会议将集中讨论小说 细胞因子控制的细胞增殖系统和 差异化。需要强调的领域包括细胞因子调控 造血和淋巴生成，信号转导机制，以及 细胞因子对基因调控和表达的影响。这次会议 关于《类风湿性关节炎及相关疾病的分子机制》一文 将强调免疫和炎症机制，这些机制导致 并使各种急性和慢性人类疾病永久化。要讨论的主题 包括环境因素的作用、作用机制、 遗传易感性与T、B细胞异常和黏附 分子。 两次会议的一个重要重点将是发展新的 人类疾病的治疗方法。联席会议将于 抑制肿瘤坏死因子或白介素1作用的最新进展。这些 会议将讨论生物基础生物学的最新发展。 IL-1ra受体拮抗剂、可溶性IL-1受体、可溶性肿瘤坏死因子 肿瘤坏死因子受体和抗体。其他演示文稿将提供 每项临床试验结果的最新信息 这些试剂。将讨论的其他新形式的治疗将包括 通过单抗干扰T淋巴细胞功能， 多肽或疫苗接种，以及重组细胞因子的使用。因此， 这两个同时举行的Keystone研讨会提供了一个独特的机会 互动的科学论坛。在基础和临床之间 对人类血液学中的细胞和细胞因子感兴趣的研究人员， 免疫性和炎症性疾病。