NOT STATED

本次Keystone研讨会将同时举办两个会议： 与细胞因子受体：从克隆到临床 风湿性关节炎和相关疾病的机制”。 许多重要 在这两个基础研究领域都取得了进展， 过去两年来，这些会议非常及时。 这些会议 是高度多学科的，汇集了来自 代表细胞研究学科的学术界和工业界 生物学，分子生物学，免疫学和生物化学，以及临床 血液学和流变学学科。 这些会议旨在 将在不同领域工作的科学家聚集在一起， 代表着不同的观点 主要目的是呈现 新的和最近的研究发现，将刺激交叉受精 在基础和临床研究者中， 细胞因子和人类疾病的机制。 关于“细胞因子和细胞因子受体”的会议将重点关注新的 细胞增殖和细胞周期调控系统 分化 要强调的领域包括细胞因子控制， 造血和淋巴细胞生成，信号转导机制，以及 细胞因子对基因调节和表达的影响。 会议 关于“风湿性关节炎及相关疾病的分子机制” 将强调免疫和炎症机制，诱导 并使各种急性和慢性人类疾病持续存在。 话题 讨论包括环境因素的作用， 遗传易感性、T和B细胞异常和粘附 分子。 这两次会议的一个重要重点将是发展新的 人类疾病的治疗方法。 联席会议将于 TNF或IL-1作用抑制的最新进展。 这些 会议将讨论基础生物学的最新发展， IL-1 ra受体拮抗剂，可溶性IL- 1受体，可溶性TNF TNF受体和抗体。 其他介绍将提供 每种药物临床试验结果的最新信息 这些试剂。 将要讨论的其他新形式的治疗包括 通过单克隆抗体干扰T淋巴细胞功能， 肽或疫苗接种，以及重组细胞因子的使用。 因此，在本发明中， 这两个同时举行的基石研讨会提供了一个独特的机会， 科学论坛互动。在基础和临床之间 研究人员对人类血液学中的细胞和细胞因子感兴趣， 免疫和炎症疾病。

This Keystone Symposium will offer two concurrent meetings: "Cytokines and Cytokine Receptors: From Cloning to the Clinic" and "Molecular Mechanisms in Rheumatoid Arthritis and Related Diseases". Many important advances have been made in both of these areas of basic research over the past two years making these meetings extremely timely. These meetings are highly multidisciplinary, bringing together investigators from academia and industry representing the research disciplines of cell biology, molecular biology, immunology and biochemistry, and the clinical disciplines of hematology and rheumatology. These meetings are intended to bring together scientists who are working in competing areas and may represent different points of view. The prime objective is to present new and recent research findings that will stimulate cross-fertilization among basic and clinical investigators sharing a common interest in cytokines and mechanisms of human diseases. The meeting on "Cytokines and Cytokine Receptors" will focus on novel cytokine-controlled systems of cellular proliferation and differentiation. Areas to be emphasized include cytokine control of hematopoiesis and lymphopoiesis, mechanisms of signal transduction, and cytokine influence on both gene regulation and expression. The meeting on "Molecular Mechanisms in Rheumatoid Arthritis and Related Diseases" will emphasize the immunologic and inflammatory mechanisms that induce and perpetuate a variety of acute and chronic human diseases. Topics to be discussed include the role of environmental factors, mechanisms of genetic predisposition, T and B cell abnormalities and adhesion molecules. An important emphasis of both meetings will be on the development of new therapeutic approaches to human disease. Joint sessions will be held on recent developments in the inhibition of TNF or IL-1 action. These sessions will discuss the latest developments in the basic biology of the IL-1ra receptor antagonist, soluble IL- 1 receptors, soluble TNF receptors and antibodies to TNF. Additional presentations will provide up-to-date information on the results of clinical trials with each of these reagents. Other new forms of therapy to be discussed will include interference with T lymphocyte function through Monoclonal antibodies, peptides or vaccination, and the use of recombinant cytokines. Thus, these two concurrent Keystone symposia offer an opportunity for a unique scientific forum with interactions. between basic and clinical investigators interested in cells and cytokines in human hematologic, immunologic and inflammatory diseases.