A central role for carbonic anhydrase in renal hypertrophy and interstitial fibrosis

碳酸酐酶在肾肥大和间质纤维化中的核心作用

• 批准号: nhmrc : 569729
• 负责人: Prof Joseph Casey
• 金额: $ 27.66万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/central-role-carbonic-interstitial-fibrosis/81270
• 关键词: central; role; carbonic; anhydrase; renal

1 in 3 Australians are at risk of developing kidney disease. Renal replacement therapies (dialysis and transplantation) currently cost over $1.2 billion per year. These therapies do not address the underlying cause of the disease. Much research has focused on novel strategies to reverse kidney damage with mixed success. In this project we examine a novel preventative strategy based on currently available therapeutics that may slow the progression of kidney disease.

三分之一的澳大利亚人有患肾病的风险。肾脏替代疗法（透析和移植）目前每年花费超过12亿美元。这些疗法并不能解决这种疾病的根本原因。许多研究都集中在逆转肾损伤的新策略上，取得了不同程度的成功。在这个项目中，我们研究了一种新的预防策略，该策略基于当前可用的治疗方法，可以减缓肾脏疾病的进展。