A central role for ER-Golgi trafficking in motor neuron disease

ER-高尔基体运输在运动神经元疾病中的核心作用

• 批准号: nhmrc : 1030513
• 负责人: A/Pr Julie Atkin
• 金额: $ 28.98万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/central-role-er-neuron-disease/110759
• 关键词: central; role; ER; Golgi; trafficking

Amyotrophic lateral sclerosis (ALS) patients currently face a bleak future. In the common global form of disease, the average length of survival after diagnosis is 31 months. Current therapies have at best a modest effect on the course of the disease with little or no benefit in terms of overall patient survival. This study will address the basic underlying biochemical mechanisms of disease in both sporadic and genetic forms of ALS. This studies will lead to opportunities to develop new therapies in the future.

肌萎缩侧索硬化症（ALS）患者目前面临着一个暗淡的未来。在常见的全球疾病形式中，诊断后的平均生存时间为31个月。目前的治疗方法对疾病的进程最多有适度的影响，在总体患者生存方面几乎没有或没有益处。这项研究将解决疾病的基本生化机制在散发和遗传形式的ALS。这些研究将为未来开发新疗法带来机会。