FASEB--FOLATE, B12 & ONE CARBON METABOLISM

要求提供资金，部分支助第四次会议， 叶酸、维生素B 12和一碳代谢，将在 由美国实验动物学会联合会赞助， 生物学（FASEB）从1992年8月2日至7日在佛蒙特州学院，萨克斯顿的 佛蒙特州里弗 本次会议提供了一个独特的机会， 医生科学家和基础科学家， 学科，他们对叶酸，B12和一个碳都感兴趣 新陈代谢，正式和非正式的互动。 最后两 会议已全部订阅，并参加这一 会议将限制在150人。 要求提供资金， 国际科学家的广泛参与， 学生，居民和博士后研究员在这一领域工作， 出席会议。 一个详细的程序，并包括两个 有经验的科学家和刚进入这个领域的科学家。 一 会议的主要焦点将是开发和测试 针对叶酸依赖性酶的化疗剂，和 参与叶酸和钴胺素生物合成的酶。 班 叶酸和钴胺素依赖的机制 酶，这些酶的结构，对运输和 叶酸盐、抗叶酸剂和钴胺素衍生物的区室化，和 抗叶酸剂的临床评价，现在在临床的各个阶段， 审判 第二个主要焦点将是叶酸的作用， 代谢中的B12依赖酶。 会议计划在 评估正常人和患病人的营养状况， 以及干预叶酸的药物对代谢的影响， 钴胺素依赖性反应 该计划将补充与 海报会议。 海报会议提供了许多机会， 非正式讨论，并允许学生，居民和博士后 研究员，以及建立科学家，有机会提出 讨论他们的工作。 最有趣的新研究是在 会议将以下列形式向更广泛的受众传播： 一个或多个“国家的最先进的”评论在FASEB杂志。

Funds are requested for partial support of the fourth Conference on Folic Acid, Vitamin B 12 and One Carbon Metabolism, to be held under the auspices of the Federation of American Societies for Experimental Biology (FASEB) from August 2-7, 1992 at Vermont Academy, Saxton's River, Vermont. This conference offers a unique opportunity for physician scientists and basic scientists from a broad group of disciplines, who share an interest in folate, B12 and one carbon metabolism, to interact both formally and informally. The last two conferences have been fully subscribed, and participation at this conference will be limited to 150 people. Funds are requested to permit broad participation from international scientists and to allow graduate students, residents and postdoctoral fellows working in this area to attend the meeting. A detailed program is presented, and includes both well established scientists and scientists just entering the field. A major focus of the meeting will be the development and testing of chemotherapeutic agents directed against folate-dependent enzymes and enzymes involved in folate and cobalamin biosynthesis. Sessions have been scheduled on the mechanisms of folate- and cobalamin-dependent enzymes, on the structures of these enzymes, on the transport and compartmentation of folates, antifolates and cobalamin derivatives, and on clinical evaluation of antifolates now in various phases of clinical trial. A second major focus will be on the role of folate and B12-dependent enzymes in metabolism. Sessions are planned on the evaluation of the nutritional status of both normal and diseased humans, and the effects on metabolism of drugs that intervene in folate and cobalamin-dependent reactions. The program will be complemented with poster sessions. The poster sessions offer many opportunities for informal discussion and allow students, residents and postdoctoral fellows, as well as established scientists, an opportunity to present and discuss their work. 'Re most interesting new research presented at the conference will be disseminated to a much wider audience in the form of one or more "state-of-the-art" reviews in the FASEB Journal.