Why the Folate Controversy Persists: The Biosocial Complexities of Folate
为什么叶酸争议持续存在:叶酸的生物社会复杂性
基本信息
- 批准号:ES/W010607/2
- 负责人:
- 金额:$ 17.24万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The B-vitamin folate is at the centre of an ongoing controversy within science and beyond that focuses on the role and effects of folate and its synthetic form, folic acid, in health and disease. While existing research has shown that vitamins play an important role in how we understand ourselves, this research will be the first to explore the relationship between the biology and social life of folate, disrupting analyses and attempts to separate the two. This is necessary if we are to understand the biosocial complexities that constitute our everyday life, and why the folate controversy persists. Playing a vital role in cell growth and development, folate has been known for decades to help prevent birth defects, which is why women who are trying to conceive and women who are pregnant are advised to take a daily supplement of 400mg of folic acid. It is also why over 60 countries worldwide have introduced food fortification programmes, either voluntarily or mandatory. In the UK, fortification of food products with folic acid is currently voluntary in accordance with existing EU rules, but following a public consultation on the proposal to introduce mandatory fortification of flour with folic acid, the government has just recently decided to proceed with mandatory fortification and legislate on this basis. Concerns, however, have and continue to be raised by some scientists and complementary and alternative medicine (CAM) practitioners about the possible adverse health effects of high doses of folic acid, including masking of low vitamin B12 status, cognitive decline in older individuals, cancer and long-term effects of unmetabolized folic acid. In the wake of more recent scientific developments, particularly within the disciplines of nutrigenetics and nutritional epigenetics, those concerns have not been settled. Scientific explanations of folate are also increasingly debated on social media and online forums, where controversially, folic acid is advised against by some CAM practitioners. The proposed research responds to the ongoing controversy around folate and folic acid by developing an interdisciplinary and empirical account of the biosocial complexities of folate that seeks to map and analyse the different understandings of folate and positions within the debate. The aim of the research is therefore not to provide evidence for and against folate and folic acid, but to generate new knowledge about the connections between why, how and what we ingest and what these compounds do in our bodies with the aim to extend public debate and social theorising on understandings and experiences of health and disease. The long-term ambition is to create positive changes in understandings of life with chronic illness and disease that will influence scientific research, policy and priorities. I will interview scientists, policy stakeholders, CAM practitioners and lay individuals, and create a comprehensive database of documentary materials from science and healthcare databases and online media. The data collected with be analysed using different kinds of maps to visualise and examine the connections between the biology and social life of folate and to interpret the tensions, ambiguities and values at stake in the folate controversy. Research findings will be published in peer-reviewed, open-access journals and reported in online writings targeting a wider audience with the aim to shape academic and public debate on understandings of vitamins, health and disease.
B族维生素叶酸是科学内外持续争议的中心,焦点是叶酸及其合成形式叶酸在健康和疾病中的作用和影响。虽然现有的研究表明,维生素在我们如何理解自己方面发挥着重要作用,但这项研究将是第一个探索叶酸的生物学和社会生活之间关系的研究,破坏分析并试图将两者分开。如果我们要理解构成我们日常生活的生物社会复杂性,以及为什么叶酸争议持续存在,这是必要的。叶酸在细胞生长和发育中起着至关重要的作用,几十年来一直被认为有助于预防出生缺陷,这就是为什么试图怀孕的妇女和怀孕的妇女被建议每天补充400毫克叶酸。这也是为什么全世界有60多个国家自愿或强制推行食品强化计划的原因。在英国,根据现行欧盟规则,食品中添加叶酸是自愿的,但在就强制性添加叶酸的建议进行公众咨询后,政府最近决定继续强制性添加叶酸,并在此基础上立法。然而,一些科学家和补充和替代医学(CAM)从业者对高剂量叶酸可能对健康产生的不良影响表示担忧,包括掩盖低维生素B12状态,老年人认知能力下降,癌症和未代谢叶酸的长期影响。随着最近的科学发展,特别是营养遗传学和营养表观遗传学学科的发展,这些问题还没有得到解决。叶酸的科学解释也越来越多地在社交媒体和在线论坛上进行辩论,其中有争议的是,一些CAM从业者建议不要服用叶酸。拟议的研究通过对叶酸的生物社会复杂性进行跨学科和经验性的描述来回应围绕叶酸和叶酸的持续争议,旨在绘制和分析对叶酸的不同理解和辩论中的立场。因此,这项研究的目的不是提供支持和反对叶酸和叶酸的证据,而是产生关于我们为什么、如何和什么摄入以及这些化合物在我们体内的作用之间联系的新知识,旨在扩大公众辩论和社会理论对健康和疾病的理解和经验。长期目标是在对慢性病和疾病生活的理解方面创造积极的变化,这将影响科学研究,政策和优先事项。我将采访科学家、政策利益相关者、CAM从业者和非专业人士,并从科学和医疗保健数据库和在线媒体中创建一个全面的文献材料数据库。收集的数据将使用不同类型的地图进行分析,以可视化和检查叶酸的生物学和社会生活之间的联系,并解释叶酸争议中的紧张局势,模糊性和价值观。研究结果将发表在同行评审的开放获取期刊上,并在针对更广泛受众的在线文章中进行报道,旨在塑造关于维生素,健康和疾病理解的学术和公共辩论。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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Mette Furbo的其他文献
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{{ truncateString('Mette Furbo', 18)}}的其他基金
Why the Folate Controversy Persists: The Biosocial Complexities of Folate
为什么叶酸争议持续存在:叶酸的生物社会复杂性
- 批准号:
ES/W010607/1 - 财政年份:2022
- 资助金额:
$ 17.24万 - 项目类别:
Research Grant
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Why the Folate Controversy Persists: The Biosocial Complexities of Folate
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