Chemotherapy-induced peripheral neuropathy in the pediatric population: risk factors, assessment strategies and functional outcomes

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Chemotherapy, commonly used for treatment of childhood cancer, can cause peripheral nerve injury with disabling symptoms which may be long lasting. This project aims to provide a comprehensive evaluation of the nerve injury and standardize sensitive ways of measuring nerve function. This is the first study that will follow children throughout their treatment cycle with regular nerve assessments, providing a greater understanding of nerve injury mechanisms and enabling treatment modification.