TRH MODULATION OF LTP AND SEIZURE ACTIVITY

TRH 对 LTP 和癫痫活动的调节

• 批准号: 3437858
• 负责人: DAVID L QUINN
• 金额: $ 6.25万
• 依托单位: MUSKINGUM COLLEGE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3437858
• 关键词: animal age group; anticoagulants; brain electrical activity; brain mapping; electrodes; electrostimulus; generalized seizures; hippocampus; hormone receptor; laboratory rat; memory; pituitary thyroid axis; thyrotropin releasing hormone; thyroxine

The proposed experiments are designed to study the action of thyrotropin releasing hormone on electrically induced seizures and long-term potentiation. Electrical stimulation of the afferent pathways to the CA1, CA3, and dentate granule cells will occur in the presence and absence of TRH. Detailed dose-response curves will be established in an attempt to determine if TRH alters either LTP or seizure induction. Additionally, the action of TRH on the ventral vs. the dorsal hippocampus will be contrasted. TRH receptors exist in a high concentration in the ventral hippocampus (CA3) and ventral dentate gyrus. The long-term objectives of this project are related to the possible actions of TRH in maintenance of overall excitability of the nervous system, in the control of seizure activity, and influence on memory formation. TRH is well known to control human behavior indirectly through its action on the pituitary and thyroid gland. The question of whether or not TRH directly controls the excitability of the brain remains to be determined. These studies will eventually need to include young, middle-aged and old rats of both sexes.

所提出的实验旨在研究 促甲状腺激素释放激素对电诱发癫痫发作的影响， 长时程增强 传入神经的电刺激 到CA 1、CA 3和齿状颗粒细胞的通路将发生在 TRH的存在和不存在。 详细的剂量-反应曲线 将建立一个试图确定是否TRH改变 LTP或癫痫诱导。 此外，TRH的作用 对比腹侧海马体和背侧海马体。 TRH受体以高浓度存在于腹侧 海马（CA 3）和腹侧齿状回。 该项目的长期目标与以下方面有关： TRH在维持整体兴奋性中的可能作用 神经系统，控制癫痫发作活动， 对记忆形成的影响 TRH是众所周知的控制 通过对脑垂体的作用间接影响人类行为， 甲状腺 TRH是否直接 控制大脑的兴奋性仍有待确定。 这些研究最终需要包括年轻的，中年的， 和老老鼠的性别。