IRON POLYENE COMPLEXES APPLIED TO ORGANIC SYNTHESIS

本建议涉及(环庚三烯)铁的应用 三羰基和(环庚三烯酮)铁三羰基合成有机化合物 综合。这两者都有许多吸引人的特点 推荐它们在合成中的应用。多数 重要的是，Fe(CO)3碎片挡住了 配合环，为立体选择提供机会 碳-碳键形成反应。 提案讨论了简单阐述以下内容的方法 (C7H8)Fe(CO)3和(C7H6O)Fe(CO)3。 方法学，考虑了几种环化方案。 其中包括：侧链上的亲核协同攻击 双烯，环心对侧链的烯醇化攻击和Lewis 酸诱导的二乙烯基酮的环化反应。方法论 在本提案中开发的将提供多种中间体 构象不稳定的天然产物的立体控制合成 健康科学感兴趣的产品。

This proposal concerns the application of (Cycloheptatriene) Iron Tricarbonyl and (Cycloheptatrieneone) Iron Tricarbonyl to organic synthesis. Both of these have a number of attractive features which recommend their application to synthesis. Most importantly, the Fe(CO)3 fragment blocks one face of the coordinated ring, providing the opportunity for stereoselective carbon-carbon bond forming reactions. The proposal discusses methods for the simple elaboration of (C7H8)Fe(CO)3 and (C7H6O)Fe(CO)3. Building upon this methodology, several schemes for cyclization are considered. These include: side-chain nucleophilic attack on the coordinated diene, ring-centered enolate attack on the side chain and Lewis acid induced cyclization of a divinyl ketone. The methodology developed in this proposal will provide versatile intermediates for the stereocontrolled synthesis of conformationally labile natural products of interest to the health sciences.