IRON POLYENE COMPLEXES APPLIED TO ORGANIC SYNTHESIS

本建议涉及（环庚三烯）铁的应用 三羰基和（环庚三烯酮）三羰基铁到有机 合成. 这两个都有一些吸引人的特点 推荐了它们在合成中的应用。 最 重要的是，Fe（CO）3碎片阻挡了 协调环，提供立体选择性的机会， 碳-碳键形成反应。 该提案讨论了简单阐述 （C7H8）Fe（CO）3和（C7H6O）Fe（CO）3。 在此基础上 方法，几个方案的环化被认为是。 这些包括：侧链上的配位亲核攻击 二烯，环中心烯醇化攻击的侧链和刘易斯 二乙烯基酮的酸诱导环化。 的方法 本提案中开发的产品将提供多用途中间体， 构象不稳定天然产物的立体控制合成 健康科学感兴趣的产品。

This proposal concerns the application of (Cycloheptatriene) Iron Tricarbonyl and (Cycloheptatrieneone) Iron Tricarbonyl to organic synthesis. Both of these have a number of attractive features which recommend their application to synthesis. Most importantly, the Fe(CO)3 fragment blocks one face of the coordinated ring, providing the opportunity for stereoselective carbon-carbon bond forming reactions. The proposal discusses methods for the simple elaboration of (C7H8)Fe(CO)3 and (C7H6O)Fe(CO)3. Building upon this methodology, several schemes for cyclization are considered. These include: side-chain nucleophilic attack on the coordinated diene, ring-centered enolate attack on the side chain and Lewis acid induced cyclization of a divinyl ketone. The methodology developed in this proposal will provide versatile intermediates for the stereocontrolled synthesis of conformationally labile natural products of interest to the health sciences.