DEVELOPMENTAL ASPECTS OF UPPER GASTROINTESTINAL MOTILITY

婴儿期胃食道反流是一种常见的疾病，可 严重的后果。尽管它在新生儿时期经常发生 期间，我们对发展因素了解甚少 使婴儿易患胃食道反流。 该项目将研究与年龄有关的机械性能的变化 上胃肠道运动的神经体液调节 一条小路。它将定义发育变化在形状、大小、 和几何学对上胃肠道发育能力的影响 力量和压力。 这些变化的影响将通过以下方式进行评估： 1)。组织的体外检查以确定力的长度和应力 发育中的食道、胃和它们之间的应变关系 括约肌。 2)。用分离肌细胞技术确定年龄对细胞的影响 大小和对建议的神经体液递质的反应性。 3)。评估年龄对以下方面影响的活体研究： A)维持和调节下段食道上括约肌 食道括约肌张力和松弛，以及食道蠕动。 B)胃内压力-体积关系的发展。 上胃肠道增龄相关改变的系统研究 运动能使临床常见问题得到更合理的治疗。 婴儿时期的胃食道反流。

Gastroesophageal reflux of infancy is a common disorder which can have serious consequences. Despite its frequent occurrence during the newborn period, we understand little about the developmental factors that predispose the infant to gastroesophageal reflux. This project will examine the age related changes in mechanical properties and neurohumoral modulation of motility in the upper gastrointestinal tract. It will define the effect of developmental changes in shape, size, and geometry on the ability of the upper gastrointestinal tract to develop forces and pressures. The effects of these changes will be assessed through: 1). In vitro examination of tissue to determine force length and stress strain relationships of the developing esophagus, stomach, and their sphincters. 2). Isolated muscle cell techniques to determine the effect of age on cell size and the responsiveness to proposed neurohumoral transmitters. 3). In vivo studies to evaluate the effect of age on: a) Maintenance and modulation of upper esophageal sphincter, lower esophageal sphincter tone and relaxation, and esophageal peristalsis. b) Development of pressure volume relationships in the stomach. This systematic approach to age related changes in upper gastrointestinal motility will lead to more rational therapy for the common clinical problem of gastroesophageal reflux during infancy.