DEVELOPMENTAL ASPECTS OF UPPER GASTROINTESTINAL MOTILITY

上胃肠动力的发育方面

• 批准号: 3469318
• 负责人: A Craig HILLEMEIER
• 金额: $ 10.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3469318
• 关键词: cats; esophagogastric junction; esophagus motility /pressure; gastrointestinal motility /pressure; growth /development; human age group; infant human (0-1 year); neurotransmitters; reflux esophagitis; stomach motility /pressure

Gastroesophageal reflux of infancy is a common disorder which can have serious consequences. Despite its frequent occurrence during the newborn period, we understand little about the developmental factors that predispose the infant to gastroesophageal reflux. This project will examine the age related changes in mechanical properties and neurohumoral modulation of motility in the upper gastrointestinal tract. It will define the effect of developmental changes in shape, size, and geometry on the ability of the upper gastrointestinal tract to develop forces and pressures. The effects of these changes will be assessed through: 1). In vitro examination of tissue to determine force length and stress strain relationships of the developing esophagus, stomach, and their sphincters. 2). Isolated muscle cell techniques to determine the effect of age on cell size and the responsiveness to proposed neurohumoral transmitters. 3). In vivo studies to evaluate the effect of age on: a) Maintenance and modulation of upper esophageal sphincter, lower esophageal sphincter tone and relaxation, and esophageal peristalsis. b) Development of pressure volume relationships in the stomach. This systematic approach to age related changes in upper gastrointestinal motility will lead to more rational therapy for the common clinical problem of gastroesophageal reflux during infancy.

婴儿胃食管反流是一种常见的疾病， 严重后果 尽管它在新生儿时期经常发生， 在这一时期，我们对发展因素了解甚少， 使婴儿易患胃食管反流。 这个项目将研究与年龄有关的机械性能的变化 和上消化道运动的神经体液调节 道。 它将定义形状，大小， 和几何形状对上消化道发育能力的影响 力量和压力。 将通过以下方式评估这些变化的影响： 1）。体外组织检查以确定力长度和应力 发育中的食管、胃及其周围组织的应变关系 括约肌 2）。分离肌细胞技术以确定年龄对细胞的影响 大小和对神经体液递质的反应性。 3）。评价年龄对以下方面影响的体内研究： a）维持和调节上食管括约肌、下食管括约肌和下食管括约肌。 食管括约肌张力和松弛以及食管扩张。 B）胃中压力容积关系的发展。 这种系统的方法，年龄相关的变化，上消化道， 动力学将导致更合理的治疗常见的临床问题 胃食管反流的症状