SELECTIVE PHOTOCOAGULATION OF CHOROIDAL VESSELS

我们的目标是建立一个理论和实验模型， 脉络膜血管凝固。 虽然激光在 在眼科疾病的治疗中，眼科激光的发展 在很大程度上是经验性的，因为激光的可用性 源确定哪些波长，脉冲宽度，和能量， 研究了 激光在眼科的应用前景 很可能依赖于激光和技术的发展来限制 激光对特定组织或超微结构目标的影响。 我们建议 (1)扩展我们的初步研究， 评估用于优化选择性光热的策略（选择性光热） 关闭脉络膜和视网膜血管，同时最大限度地减少对 神经视网膜;（2）使用理论模型来预测哪些波长， 脉冲持续时间和入射曝光能量密度可以最好地实现 以必要的速率进行现场选择性加热;（3）使用有选择性的目标 染料，使选择性光热可能在近红外 区域，在首先对技术进行建模以选择最佳可用技术之后， 染料和波长。 这种方法具有巨大的潜在价值，因为 染料靶向的选择性光热作用， 对视网膜色素上皮细胞和神经细胞的直接影响 视网膜可用于各种手术，潜在地减少损伤 对神经视网膜的影响;（4）在动物模型中进行一系列研究 旨在将连续的临床、组织学和超微结构 对激光照射的反应，以及基于物理 模型和治疗目标。 翠绿宝石、铒和可调谐染料 在这些研究中将使用激光。

We aim to develop a theoretical and experimental model for selective coagulation of choroidal vessels. Although lasers occupy an important role in the treatment of ocular disease, the development of ophthalmic lasers has been, in large measure, empirical because the availabililty of laser sources determined which wavelengths, pulsewidths, and energies were studied. The development of future applications of lasers in ophthalmology is likely to rely on the development of lasers and techniques to confine laser effects to specific tissue or ultrastructural targets. We propose to (1) extend our preliminary studies in developing and experimentally evaluating a strategy (selective photothermolysis) for optimizing selective closure of choroidal and retinal vessels while minimizing damage to the neural retina; (2) use theoretical models to predict which wavelengths, pulse durations and incident exposure energy densities can best achieve site selective heating at the rates necessary; (3) use selectively targeted dyes to make selective photothermolysis possible in the near infrared region, after first modelling the technique to select the best available dyes and wavelengths. This approach is of great potential value because dye-targeted selective photothermolysis at wavelengths which avoid significant direct effects upon the retinal pigment epithelium and neural retina may be used for a variety of procedures, potentially reducing damage to the neural retina; (4) perform in animal models a series of studies designed to correlate sequential clinical, histological and ultrastructural responses to laser exposures with theoretical predictions based on physical models and with therapeutic goals. Alexandrite, erbium and tunable dye lasers will be used in these studies.