A NEW INTRARENAL NEUROVASCULAR STRUCTURE

一种新的肾内神经血管结构

• 批准号: 3448941
• 负责人: DAVID S KNIGHT
• 金额: $ 3.31万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3448941
• 关键词: 6 hydroxydopamine; afferent nerve; arterioles; axon; catecholamines; chemoreceptors; dopamine beta monooxygenase; electron microscopy; fluorescence microscopy; histochemistry /cytochemistry; immunochemistry; laboratory rat; mechanoreceptors; microscopy; neurotransmitters; postganglionic fiber; renal artery; spinal nerves; substance P; sympathetic ganglion; sympathetic nervous system; synaptic vesicles; tyrosine 3 monooxygenase

General studies of intrarenal catecholamine-containing nerves have shown that these sympathetic nerves form dense plexuses around the renal arteries and veins. Intrarenal sensory nerves are both chemoreceptive and mechanoreceptive, but data on receptor distribution are minimal and the fine structure of sensory terminals and the neurotransmitters used by these nerves are unknown. The investigator has examined with the electron microscope, a new intrarenal structure consisting of a cluster of axonal enlargements that partially surround arterioles and contain catecholamine in high concentration. Functionally, axons of this neurovascular structure may be efferent or afferent. The objectives of the proposed project are to study the anatomical relationships between intrarenal axonal enlargements and the renal arterial tree. Localization of sensory and autonomic nerve cell bodies innervating the kidneys and systematic section of their axons will help to establish the sensory or autonomic nature of the neurovascular structure. Immunohistochemical localization of TH, DBH, substance P, somatostatin and VIP will help to characterize the neurotransmitter used by these nerves. These data will be useful in the process of determining whether the modified axons and associated arterioles contribute significantly to renal function in healthy or in hypertensive animals.

含有培育学含有儿茶酚胺神经的一般研究已显示 这些交感神经在肾动脉周围形成密集的丛 和静脉。 肾内感觉神经都是化学感受性的，并且 机械感受器，但有关受体分布的数据很小，并且 感觉终端的精细结构和这些使用的神经递质的结构 神经未知。 研究人员已经检查了电子 显微镜，一种由轴突簇组成的新型植物结构 部分围绕小动脉并含有儿茶酚胺的扩大 高浓度。 在功能上，这种神经血管结构的轴突 可能是传出的或传入的。 拟议项目的目标是 研究牙内轴突扩大之间的解剖学关系 和肾动脉树。 感觉和自主神经的定位 细胞体支配肾脏的肾脏和系统部分 将有助于建立神经血管的感觉或自主性 结构。 TH，DBH，物质P的免疫组织化学定位 生长抑素和VIP将有助于表征由 这些神经。 这些数据将在确定的过程中有用 修饰的轴突和相关的动脉是否有贡献 在健康或高血压动物中显着具有肾功能。

项目成果

Substance P-immunoreactive nerves in the rat kidney.

P物质-大鼠肾脏中的免疫反应性神经。

• DOI: 10.1016/0165-1838(87)90017-8
• 发表时间: 1987
• 期刊: Journal of the autonomic nervous system
• 作者: Knight,DS;Beal,JA;Yuan,ZP;Fournet,TS
• 通讯作者: Fournet,TS

Vasoactive intestinal peptide-immunoreactive nerves in the rat kidney.

大鼠肾脏中的血管活性肠肽免疫反应神经。

• DOI: 10.1002/ar.1092190213
• 发表时间: 1987
• 期刊: The Anatomical record
• 作者: Knight,DS;Beal,JA;Yuan,ZP;Fournet,TS
• 通讯作者: Fournet,TS

Identification of noradrenergic nerve terminals immunoreactive for neuropeptide Y and vasoactive intestinal peptide in the rat kidney.

大鼠肾脏中对神经肽 Y 和血管活性肠肽具有免疫反应性的去甲肾上腺素能神经末梢的鉴定。

• DOI: 10.1002/aja.1001840303
• 发表时间: 1989
• 期刊: The American journal of anatomy
• 作者: Knight,DS;Fabre,RD;Beal,JA
• 通讯作者: Beal,JA

Calcitonin gene-related peptide-immunoreactive nerves in the rat kidney.

大鼠肾脏中降钙素基因相关肽免疫反应神经。

• DOI: 10.1002/aja.1001900105
• 发表时间: 1991
• 期刊: The American journal of anatomy
• 作者: Knight,DS;Cicero,S;Beal,JA
• 通讯作者: Beal,JA

Catecholamine-containing, dopamine-beta-hydroxylase-immunoreactive perivascular nerve specializations in the rat kidney.

大鼠肾脏中含有儿茶酚胺、多巴胺-β-羟化酶免疫反应性的血管周围神经特化。

• DOI: 10.1002/ar.1092250111
• 发表时间: 1989
• 期刊: The Anatomical record
• 作者: Knight,DS;Beal,JA;Fabre,RD;HendersonJr,RJ
• 通讯作者: HendersonJr,RJ