PERMANENT DEFORMATION OF COMPACT BONE

致密骨的永久变形

• 批准号: 3456701
• 负责人: CLARE M RIMNAC
• 金额: $ 8.89万
• 依托单位: HOSPITAL FOR SPECIAL SURGERY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-01-01 至 1991-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3456701
• 关键词: biomechanics; bone density; bone disorder; femur; human tissue; mechanical stress; skeletal stress; temperature; tensile strength; viscosity

It has been shown that human compact bone has the ability to plastically (permanently) deform a significant amount when loaded, though the controlling microstrural defomation mechanisms have not be clearly established. The objective of this project is to investigate the relative contribution of microstructural deformation mechanisms to the macroscopic permanent deformation of compact human bone. This goal will be achieved by examining the hypothesis that the macroscopic permanent deformation of compact human bone subjected to static loads van be modelled as a function of test and material variables. For metals and ceramics, microstructural deformation mechanisms have been identified by modelling the effect of such variables on the macroscopic creep deformatin (the time- dependent change in strain caused by the application of a constant load). Because human compact bone has been shown to experience a classic creep response like that of metals and ceramics, the same approach will be applied. The effect of temperature, stress, specimen orientation and specimen size on the creep behavior of compact human bone will be determine. The results will be used to determine the activation energy values for microstructural deformation mechanisms. These values may be correlated to the energy requirements for processes such as collagen bond disruption or cement line fracture. In addition, specimen orientation and size with respect to the bone microstructure will be varied in a further effort to determine the contribution of microstructural deformation mechanisms to the macroscopic deformation response. It is believed that this approach will successfully lead to the development of a hypothesis that microstructural deformation mechanisms of human compact bone can be identified from the model of its macroscopic permanent deformation behavior.

研究表明，人类密质骨具有 当发生显着的塑性（永久）变形时 加载，但控制微结构变形 机制尚未明确。 此举的目的 项目的目的是调查相对贡献 微观结构变形机制到宏观 致密人体骨骼的永久变形。 这个目标将是 通过检验宏观假设来实现 致密人体骨骼的永久变形 静载荷可以根据测试和材料进行建模 变量。 对于金属和陶瓷，微观结构变形 通过对此类影响进行建模，已经确定了机制 宏观蠕变变形的变量（时间 由应用常数引起的应变相关变化 加载）。 因为人类密质骨已被证明 体验像金属一样的经典蠕变响应 陶瓷，将采用相同的方法。 的效果 温度、应力、样本方向和样本尺寸 将确定致密人骨的蠕变行为。 结果将用于确定活化能值 用于微观结构变形机制。 这些值可能 与过程的能量需求相关，例如 胶原蛋白结合破坏或骨水泥线断裂。 此外， 样本相对于骨骼的方向和尺寸 微观结构将在进一步的努力中变化，以确定 微观结构变形机制的贡献 宏观变形响应。 据信，这 方法将成功地导致假设的发展 人体致密体的微观结构变形机制 骨可以从其宏观模型来识别 永久变形行为。