REPRODUCTIVE FACTORS IN HODGKIN'S DISEASE IN WOMEN

这项以人群为基础的病例对照流行病学研究将检查 生殖因素和外源性激素使用影响女性罹患 霍奇金氏病(HD)，一种鲜为人知的淋巴瘤。高清费率较低 成年女性多于男性，尤其是在生育年龄。尽管 HD的描述性流行病学表明生育具有保护作用 临床和实验数据均表明，黄连胶囊具有抑制作用。 淋巴瘤妊娠，除产次外，无生殖或性激素使用因素 曾接受过HD风险评估。之前的两项研究 考虑到平价和HO风险，发现了强烈但相反的关联。这 矛盾需要解决，荷尔蒙的未知假说 现有证据对高血压病风险的影响需要评估。 具体的研究目标是：1)确定产次是否能预防HD风险， 如果效果是长期的或暂时的(暗示肿瘤抑制 在怀孕期间)；2)确定其他生殖因素 独立影响高清 风险；3)探讨外源性激素使用对HD风险的影响；4) 请查看 在组织学类型的亚组中以上风险；5)始终控制 潜在的混杂因素(例如，社会阶层)。拟议的为期5年的研究将 包括315名新诊断为组织学确诊HD的妇女，以及315名 控制女性，来自旧金山湾区的9个县。案件将会是 是通过基于人群的肿瘤登记来确定的。基于人口 控制将通过随机数字拨号和频率匹配来识别 关于年龄、种族和电话号码的案例-区号和前缀。所有科目 将就人口统计数据(包括社会地位)进行面谈； 医学史；月经和生育史；生育经历 (每次怀孕的年龄、持续时间和出生时间；哺乳期)；以及外生子 荷尔蒙使用。将估计与研究因素相关的相对风险 用Logistic回归方法对HD的总体和组织学亚型进行分析， 并根据社会阶层和其他混杂因素进行调整。学习压力 包括：1)一种新的和可行的方法来调查一种 癌症帽子，既影响年轻人，也影响老年人，是特别重要的 关注公众健康；彻底检查激素的影响 通过调查一个完整的因素提出假设；3)使用 以人群为基础的病例，对于完整、无偏见的较高受试者来说，可以检测到2- 全面型HD的3倍相关风险；4)使用以人群为基础的 对照，减少S的偏见；5)详细关注疑似 混杂因素，

This population-based, case-control epidemiologic study will examine whethe reproductive factors and exogenous homone use affect women's risk of Hodgkin's disease (HD), a poorly understood lymphoma. HD rates are lower in adult women than men, particularly at reproductive ages. Although the descriptive epidemiology of HD suggests a protective effect of childbearing and both clinical and experimental data show an inhibitory effect of pregnancy on lymphomas, no reproductive or homone-use factors except parity have ever been evaluated regarding HD risk. The two prior studies considering parity and HO risk found strong but opposing associations. This discrepancy requires resolution, and the unexplored hypothesis of hormonal influence on HD risk suggested by existing evidence needs evaluation. Specific study aims are: 1) to detemine if parity protects against HD risk, and if the effect is long-term or temporary (suggesting tumor suppression during pregnancy);2) to determine whether other reproductive factors independently affect HD risk; 3) toexplore the effects of exogenous hormone use on HD risk; 4) to examine the above risks among histologic-type subgroups; 5) to control throughout for potential confounders (e.g., social class). The proposed 5-year study will include 315 women newly diagnosed with histologically confirmed HD, and 315 control women, from 9 counties in the San Francisco Bay Area. Cases will be ascertained through population-based tumor registries. Population-based controls will be identified by random-digit dialing, and requency-matched to cases on age, race and phone number area-code and Prefix. All subjects ill be interviewed in person about demographics (including social status); medical istory; menstrual and fertility history; reproductive experience (age at, duration of and utcome of each pregnancy; lactation); and exogenou hormone use. Relative risks assocated with study factors will be estimated with logistic regression methods for HD overall nd by histologic subtype, with adjustment for social class and other confounders. Study trengths include: 1) a new and feasible approach to investigating the etiology of a cancer hat, by affecting young as well as older persons, is of particular public health concern; thorough examination of the hormone-influence hypothesis through investigation of a full factors; 3) use of population-based cases, for complete, unbiased ugh subjects to detect 2- to 3-fold associated risks for HD overall type; 4) use of population-based controls, reducing biases from s; and 5) detailed attention to suspected confounding factors,